Search results for "GSK"

Living alone, receiving help, helplessness, and inactivity are strongly related to risk of undernutrition among older home-dwelling people

2012

Solveig T Tomstad1, Ulrika Söderhamn2, Geir Arild Espnes3, Olle Söderhamn21Department of Social Work and Health Science, Faculty of Sciences and Technology Management, NTNU, Trondheim, Norway and Centre for Caring Research – Southern Norway, Faculty of Health and Sport Sciences, University of Agder, Grimstad, Norway; 2Centre for Caring Research – Southern Norway, Faculty of Health and Sport Sciences, University of Agder, Grimstad, Norway; 3Research Centre for Health Promotion and Resources HiST-NTNU, Department of Social Work and Health Science, Faculty of Social Sciences and Technology Management, NTNU, Trondheim, NorwayBackground: Being at risk of und…

Psychometric testing of the Norwegian version of the Nutritional Form For the Elderly among older home-dwelling people

2012

Ulrika Söderhamn, Bjørg Dale, Kari Sundsli, Solveig T Tomstad, Olle SöderhamnCenter for Caring Research, Southern Norway, Faculty of Health and Sport Sciences, University of Agder, Grimstad, NorwayBackground: Nutritional screening instruments need to be evaluated in terms of reliability and validity and being able to demonstrate sensitivity and specificity for use in clinical practice and research. The aims of this study were to test the reliability and validity of the Norwegian version of the Nutritional Form For the Elderly (NUFFE-NO) in a sample of older home-dwelling people, and to use the short form of the Mini Nutritional Assessment (MNA-SF) as a standard.…

Hops-ohjaus : osaamista, yhteistyötä ja hyvinvointia

2011

Kapitāla augļi kā ražošanas izmaksa

1933

Saturs (nodaļas): I. Ievads. II. Vai kapitāla augļi ir izmaksas sastāvdaļa? III. Kapitāla augļi pašizmaksas un rezultātu aplēsēs. IV. Kapitāla augļu kā izmaksas sastāvdaļas aplēšana un grāmatošana. V. Slēdziens. Die Kapitalzinsen als Produktionskosten (Zusammenfassung)

Riga devicta ab augustissimo principe Gvstavo Adolpho Svecorvm, Gothorvm, Vandalorvmqve rege, magno principe Finlandiae, duce Esthoniae, Careliaque, …

1625

Saturs:Apsveikuma dzejolis: Illustri ac generoso Domino Iacobo de la Gardie [..] Rigensis Gubernatori &c. post devictam Derpatum, plurimasque arces Livoniae, filiola divinitus orbato [39.-40.] lpp. (Grāfam Jakobam Delagardijam Zviedrijas militārajam un valsts darbiniekam, feldmaršalam (1620), Zviedru Vidzemes ģenerālgubernatoram (1621–1628)). Izdevums pieejams arī: https://digital.slub-dresden.de/werkansicht/dlf/20246/

Facetten der literarischen Übersetzung

2018

Katalog der dritten baltischen landwirtschaftlichen Ausstellung zu Riga, im Jahre 1880

1880

Inhalt: I. Theil. Gruppirung nach fortlaufender Schnuppen- und Ordnungsnummern ; II. Theil. Gruppirung nach Prämiirungs-Kategorien ; III. Theil. Alphabetisches Verzeichniß der Aussteller nebst Angabe ihrer Ausstellungsobjecte.

Multifaceted roles of GSK-3 and Wnt/beta-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention

2013

Glycogen synthase kinase-3 (GSK-3) is well documented to participate in a complex array of critical cellular processes. It was initially identified in rat skeletal muscle as a serine/threonine kinase that phosphorylated and inactivated glycogen synthase. This versatile protein is involved in numerous signaling pathways that influence metabolism, embryogenesis, differentiation, migration, cell cycle progression and survival. Recently, GSK-3 has been implicated in leukemia stem cell pathophysiology and may be an appropriate target for its eradication. In this review, we will discuss the roles that GSK-3 plays in hematopoiesis and leukemogenesis as how this pivotal kinase can interact with mul…

Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells

2015

Pancreatic cancer is currently the fourth most common cancer, is increasing in incidence and soon will be the second leading cause of cancer death in the USA. This is a deadly malignancy with an incidence that approximates the mortality with 44,000 new cases and 36,000 deaths each year. Surgery, although only modestly successful, is the only curative option. However, due the locally aggressive nature and early metastasis, surgery can be performed on less than 20% of patients. Cytotoxic chemotherapy is palliative, has significant toxicity and improves survival very little. Thus new treatment paradigms are needed desperately. Due to the extremely high frequency of KRAS gene mutations (>90%) d…

Investigating and re-evaluating the role of glycogen synthase kinase 3 beta kinase as a molecular target for cardioprotection by using novel pharmaco…

2019

Aims Glycogen synthase kinase 3 beta (GSK3β) link with the mitochondrial Permeability Transition Pore (mPTP) in cardioprotection is debated. We investigated the role of GSK3β in ischaemia (I)/reperfusion (R) injury using pharmacological tools. Methods and results Infarct size using the GSK3β inhibitor BIO (6-bromoindirubin-3'-oxime) and several novel analogues (MLS2776-MLS2779) was determined in anaesthetized rabbits and mice. In myocardial tissue GSK3β inhibition and the specificity of the compounds was tested. The mechanism of protection focused on autophagy-related proteins. GSK3β localization was determined in subsarcolemmal (SSM) and interfibrillar mitochondria (IFM) isolated from Lang…