Search results for "GSK"
showing 10 items of 82 documents
Molecular mechanisms linking amyloid β toxicity and Tau hyperphosphorylation in Alzheimer׳s disease
2015
Neurofibrillary tangles (aggregates of cytoskeletal Tau protein) and senile plaques (aggregates mainly formed by amyloid β peptide) are two landmark lesions in Alzheimer׳s disease. Some researchers have proposed tangles, whereas others have proposed plaques, as primary lesions. For a long time, these were thought of as independent mechanisms. However, experimental evidence suggests that both lesions are intimately related. We review here some molecular pathways linking amyloid β and Tau toxicities involving, among others, glycogen synthase kinase 3β, p38, Pin1, cyclin-dependent kinase 5, and regulator of calcineurin 1. Understanding amyloid β and Tau toxicities as part of a common pathophys…
Number 1Epithelial biology
2005
The oral mucous membrane has features similar to skin but also differs in several ways. This paper reviews the aspects of epithelial biology necessary for an understanding of the vesiculoerosive disorders.
α-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligoden…
2011
Abstract In important and severe neurodegenerative pathologies, 7-ketocholesterol, mainly resulting from cholesterol autoxidation, may contribute to dys- or demyelination processes. On various cell types, 7-ketocholesterol has often been shown to induce a complex mode of cell death by apoptosis associated with phospholipidosis. On 158N murine oligodendrocytes treated with 7-ketocholesterol (20 μg/mL corresponding to 50 μM, 24–48 h), the induction of a mode of cell death by apoptosis characterised by the occurrence of cells with condensed and/or fragmented nuclei, caspase activation (including caspase-3) and internucleosomal DNA fragmentation was observed. It was associated with a loss of tr…
Neoclassical Convergence Versus Technological Catch-Up : A Contribution for Reaching a Consensus.
2004
http://www.businessperspectives.org/files/ppm/PPM_EN_2004_03pp15_42.pdf; International audience; New macro empirical evidence is provided to assess the relative importance of object andidea gaps in explaining the world income distribution dynamics over a benchmark period of 1960-1985. Results are then extended through 1995. Formal statistical hypothesis tests allow us to discriminatebetween two competing growth models: (i) the standard neoclassical growth model similarto that employed by Mankiw, Romer, and Weil (1992), and (ii) an endogenous growth modelclosely related to the Nelson and Phelps' approach (1966) that emphasizes the importance of technologytransfer in addition to factor accumu…
Differential expression pattern of the novel serine/threonine kinase, STK33, in mice and men
2005
Serine/threonine kinase 33 (STK33/Stk33) is a recently discovered gene whose inferred amino acid sequence translation displays characters typical for a calcium/calmodulin dependent kinase (CAMK). In this study we analysed the STK33/Stk33 RNA and protein distribution and the localization of the protein. The STK33/Stk33 expression pattern resembles those of some related members of the CAMK group. STK33/Stk33 displays a nonubiquitous and, in most tissues, low level of expression. It is highly expressed in testis, particularly in cells from the spermatogenic epithelia. Moreover, significant expression is detected in lung epithelia, alveolar macrophages, horizontal cells in the retina and in emb…
Synthesis of new derivatives of Nortopsentin with potential inhibitory activity against GSK-3b
The bryophyte flora of Lågskär - An isolated island in the Baltic Sea
2014
This study reports the bryophyte flora of Lågskär, an isolated lighthouse island in the Åland province of Finland. A total of 81 bryophyte species were found on Lågskär, including 74 moss species and seven liverwort species. Syntrichia ruraliformis is reported for the first time in Finland, whereas Ceratodon conicus was believed to be extinct in Finland and Brachythecium turgidum was considered regionally extinct from southern Finland. peerReviewed
Sørlandsporten Teknologinettverk som næringsklynge : hvilke styrker og svakheter har Sørlandsporten Teknologinettverk som regional klynge?
2014
Masteroppgave Innovasjon og kunnskapsutvikling ME513 - Universitetet i Agder 2014 Tema for denne oppgaven har vært hvilke styrker og svakheter Sørlandsporten Teknologinettverk (STN) har som en regional næringsklynge. STN er en næringsklynge innenfor mekanisk industri som er lokalisert i øst-regionen av Aust- Agder. Det er for tiden 16 ulike bedrifter tilknyttet nettverket, som samlet sysselsetter rundt 700 personer og omsetter for over en milliard NOK i året. En næringsklynge kan defineres som en kritisk masse av bedrifter i ulike deler av verdikjeden lokalisert i samme region, og har i ulike grad noen oppgraderingsmekanismer som gjør at klyngedeltakerne oppnår synergieffekter ved å delta f…
En prosjektleders handlingskompetanse : en komparativ analyse av Bygg/IndØk-studiet opp mot prosjektlederstillingen i Veidekke Entreprenør
2014
Masteroppgave i industriell økonomi og teknologiledelse IND 590 Universitetet i Agder 2014 Bakgrunnen for temaet i masteroppgaven ble bestemt ut fra hvilken problemstilling som først ble utarbeidet. Denne problemstillingen var: “Hvor stort er kompetansegapet fra nyutdannet sivilingeniør til fungerende prosjektleder?”. I samarbeid med veileder ble handlingskompetanse utpekt som relevant i en slik sammenheng, og litteratur på dette området ble innhentet. Den teoretiske forankringen til masteroppgaven baserer seg på Pär Nygrens definisjon av begrepet handlingskompetanse. Etter at litteraturstudiet var utført, ble problemstillingen bearbeidet på bakgrunn av teorien som nå var gitt. Dette result…