Search results for "GUI"

Aportación hispánica a la historia de la guitarra española hasta la publicación de las reglas de Pablo Minguet en 1754

2019

Introduction to Spreadsheet Modeling and Metaheuristics

2017

Models, as a simplified representation of reality, are used daily in an attempt to control or understand some aspects of a real system. Simplification of reality is the accepted view of the modeling process, which assumes that reality represents the absolute truth. Without getting too deep into a philosophical discourse, it is worth mentioning the notion of model-dependent realism, a phrase coined by physicists Stephen Hawkings and Leonard Molinow in their book The Grand Design. Model-dependent realism “is based on the idea that our brains interpret the input from our sensory organs by making a model of the world to aid in the decision-making process.” This implies that more than one model …

Ranking corporate sustainability: a flexible multidimensional approach based on linguistic variables

2017

Corporate sustainability implies a compromise between the present environmental, social, and economic needs of a firm's stakeholders and their future needs. Corporate sustainability is therefore a multidimensional concept. Nowadays, several independent rating agencies rate firms in terms of environmental, social, and governance (ESG) criteria. These ratings are usually used by main sustainability indices such as the Dow Jones Sustainability Index, FTSE4 Good, Stoxx Sustainability Index, or Euronext Vigeo Family to select companies to invest in. Only those firms performing better than the average of their sector are selected. However, although providing linguistic ratings about the performan…

Language constraints in producing prefiguration posters for a scientific exhibition

1997

The museographic transposition of scientific knowledge leads notably to the preparation of exhibition posters. This is a delicate operation, on account of the constraints imposed by space, language, concepts and the text. These difficulties are even greater in the case of bovine reproduction biotechnologies, such as cloning, where knowledge is not yet stable. This paper deals with the choices made during the phase of museographic transposition. First of all, based on an epistemological approach, a historical analysis of knowledge-building underpins the choice of information to be presented. Language is then selected according to the linguistic analysis of a series of articles which popular…

What Are the Success Factors of Multilingual Families? Relationships Between Linguistic Attitudes and Community Dynamics

2021

The research focuses on the influence of emotional, cognitive, and social climate on the language choices of multilingual families, and the impact they can have on their general well-being, intergenerational relationships, and the community context. The methodological framework of reference is Grounded Theory. Collected data concern language practices, attitudes, emotions, and generational, trigenerational, and social interactive dynamics of multilingual families. The results include key insights into the variables underlying the linguistic attitudes of multicultural families. Two Network Views suggest that linguistic attitudes, such as the conscious management of specific and complex dynam…

Computational processing and quality control of Hi-C, capture Hi-C and capture-C data

2019

Hi-C, capture Hi-C (CHC) and Capture-C have contributed greatly to our present understanding of the three-dimensional organization of genomes in the context of transcriptional regulation by characterizing the roles of topological associated domains, enhancer promoter loops and other three-dimensional genomic interactions. The analysis is based on counts of chimeric read pairs that map to interacting regions of the genome. However, the processing and quality control presents a number of unique challenges. We review here the experimental and computational foundations and explain how the characteristics of restriction digests, sonication fragments and read pairs can be exploited to distinguish…

Molecular Determinants of Sensitivity or Resistance of Cancer Cells Toward Sanguinarine.

2018

For decades, natural products represented a significant source of diverse and unique bioactive lead compounds in drug discovery field. In Clinical oncology, complete tumors remission is hampered by the development of drug-resistance. Therefore, development of cytotoxic agents that may overcome drug resistance is urgently needed. Here, the natural benzophenanthridine alkaloid sanguinarine has been studied for its cytotoxic activity against multidrug resistance (MDR) cancer cells. We investigated the role of the ATP-binding cassette (ABC) transporters BCRP/ABCG2, P-glycoprotein/ABCB1 and its close relative ABCB5 in drug resistance. Further drug resistance mechanisms analyzed in this study wer…

Measuring Orthorexia Nervosa: Psychometric Limitations of the ORTO-15.

2017

AbstractOrthorexia nervosa has recently been defined as excessive preoccupation with healthy eating, causing significant nutritional deficiencies and social and personal impairments. The ORTO-15 is the most widely used instrument to evaluate orthorexia nervosa, although previous studies obtained inconsistent results about its psychometric properties, and there are no data on the Spanish version. Thus, the main objective of the present study was to analyze the psychometric properties of the Spanish adaptation of the ORTO-15. In order to cross-validate the results, two independent samples were used (Sample 1: n = 807, 74.1% women; Sample 2: n = 242, 63.2% women). The results did not support t…

Antihistamine-resistant chronic spontaneous urticaria: 1-year data from the AWARE study.

2018

BACKGROUND Previous reports indicate that patients with chronic spontaneous urticaria (CSU) are undertreated and that physicians show poor adherence to guideline recommendations. Awareness of CSU has improved in recent years, but it remains unclear if this has improved the management of these patients in clinical practice. OBJECTIVE To describe disease burden, quality of life (QoL), and treatment patterns of patients with H1 -antihistamine-refractory CSU in Germany. METHOD A World-wide Antihistamine-Refractory chronic urticaria (CU) patient Evaluation (AWARE) is a global prospective, non-interventional study of CU in the real-world setting, supported by the manufacturer of omalizumab. Patie…

Application of guidelines for the management of nonalcoholic fatty liver disease in three prospective cohorts of HIV-monoinfected patients

2020

Objectives: Current guidelines recommend use of a diagnostic algorithm to assess disease severity in cases of suspected nonalcoholic fatty liver disease (NAFLD). We applied this algorithm to HIV-monoinfected patients. Methods: We analysed three prospective screening programmes for NAFLD carried out in the following cohorts: the Liver Disease in HIV (LIVEHIV) cohort in Montreal, the Modena HIV Metabolic Clinic (MHMC) cohort and the Liver Pathologies in HIV in Palermo (LHivPa) cohort. In the LIVEHIV and LHivPa cohorts, NAFLD was diagnosed if the controlled attenuation parameter (CAP) was ≥ 248 dB/m; in the MHMC cohort, it was diagnosed if the liver/spleen Hounsfield unit (HU) ratio on abdomin…