Search results for "GUIDANCE"

Online guided self-help to augment standard treatment for people with anorexia nervosa: feasibility, efficacy and process measures

2021

Background: There is mounting evidence on the effectiveness of guided self-help (GSH) interventions to augment, shorten or replace standard care for eating disorders (EDs). However, only few studies have tested the use of GSH for people with anorexia nervosa (AN). Aims: 1) to conduct a systematic review and meta-analysis of GSH in AN, with a focus on clinical outcomes and feasibility; 2) to evaluate the feasibility, acceptability and efficacy of a novel digital GSH intervention for AN (RecoveryMANTRA) tested in addition to treatment as usual (TAU) in the outpatient setting, 3) to assess predictors of drop-out from the RecoveryMANTRA + TAU condition; 4) to establish the role of working allia…

Impact of rectal distension on prostate CBCT-based positioning assessed with 6 degrees-of-freedom couch

2018

International audience; Introduction: Prostate requires a daily correction of its 3-dimensional position in relation with rectal distension. In this study, we sought to determine whether rectal distension with respect to the rectal behavior might have an impact on prostate translations and/or rotations during prostate image guided radiation therapy using a 6 degrees-of-freedom (DOF) couch.Methods and materials: We reviewed the data from 39 patients with localized prostate cancer treated with protracted external radiation therapy using a 6 DOF couch. Before each fraction, a kilovoltage cone beam computed tomography (kV-CBCT) scan was performed. The automatic fusion algorithm was set to fuse …

Functional annotation of genes overlapping copy number variants in autistic patients: focus on axon pathfinding.

2010

We have used Gene Ontology (GO) and pathway analyses to uncover the common functions associated to the genes overlapping Copy Number Variants (CNVs) in autistic patients. Our source of data were four published studies [1- 4]. We first applied a two-step enrichment strategy for autism-specific genes. We fished out from the four mentioned studies a list of 2928 genes overall overlapping 328 CNVs in patients and we first selected a sub-group of 2044 genes after excluding those ones that are also involved in CNVs reported in the Database of Genomic Variants (enrichment step 1). We then selected from the step 1-enriched list a sub-group of 514 genes each of which was found to be deleted or dupli…

Applying phenomenography in guidance and counselling research

2017

This paper examines phenomenography as a viable qualitative approach in guidance and counselling research. A phenomenographic study maps the qualitatively different ways in which people experience a specific phenomenon and helps researchers to describe the aspects that make one way of experiencing a certain phenomenon qualitatively distinct from another. This paper presents an overview of phenomenographic research, encompassing theoretical, methodological and practical considerations. The application of this approach in guidance and counselling studies is illustrated with examples. peerReviewed

Sema3a plays a role in the pathogenesis of CHARGE syndrome

2018

CHARGE syndrome is an autosomal dominant malformation disorder caused by heterozygous loss of function mutations in the chromatin remodeler CHD7. Chd7 regulates the expression of Sema3a, which also contributes to the pathogenesis of Kallmann syndrome, a heterogeneous condition with the typical features hypogonadotropic hypogonadism and an impaired sense of smell. Both features are common in CHARGE syndrome suggesting that SEMA3A may provide a genetic link between these syndromes. Indeed, we find evidence that SEMA3A plays a role in the pathogenesis of CHARGE syndrome. First, Chd7 is enriched at the Sema3a promotor in neural crest cells and loss of function of Chd7 inhibits Sema3a expression…

Dscam1 Is Required for Normal Dendrite Growth and Branching But Not for Dendritic Spacing in Drosophila Motoneurons

2014

Down syndrome cell adhesion molecule, Dscam, serves diverse neurodevelopmental functions, including axon guidance and synaptic adhesion, as well as self-recognition and self-avoidance, depending on the neuron type, brain region, or species under investigation. InDrosophila, the extensive molecular diversity that results from alternative splicing of Dscam1 into >38,000 isoforms provides neurons with a unique molecular code for self-recognition in the nervous system. Each neuron produces only a small subset of Dscam1 isoforms, and distinct Dscam1 isoforms mediate homophilic interactions, which in turn, result in repulsion and even spacing of self-processes, while allowing contact with neig…

The seven layers of complexity of recommender systems for children in educational contexts

2019

Recommender systems (RS) in their majority focus on an average target user: adults. We argue that for non-traditional populations in specific contexts, the task is not as straightforward–we must look beyond existing recommendation algorithms, premises for interface design, and standard evaluation metrics and frameworks. We explore the complexity of RS in an educational context for which young children are the target audience. The aim of this position paper is to spell out, label, and organize the specific layers of complexity observed in this context.

Designing for Mixed Reality Urban Exploration

2021

Funding Information: Acknowledgments. This work was supported by the European Union Seventh Framework Programme (grant agreement no 601139) and the Italian Ministry of Education, University, and Research (MIUR) PON AIM project (id: AIM1875400-1, CUP: B74I18000210006). Publisher Copyright: © 2021. All Rights Reserved. This paper introduces a design framework for mixed reality urban exploration (MRUE), based on a concrete implementation in a historical city. The framework integrates different modalities, such as virtual reality (VR), augmented reality (AR), and haptics-audio interfaces, as well as advanced features such as personalized recommendations, social exploration, and itinerary manage…

Tips and Tricks: Biopsies and Drainages

2018

The choice of a foreign language as university degree: Expectations and traits of study

2017

The aim of this study is to report the degree which is most demanded by students in their final year of university and training Higher Level and to analyze the influence of parameters of gender, field of study, academic and professional interests and motives in the choosing a degree or qualification Foreign Language. This study involves a total of 1,162 students from Spain, with an age between 17 and 21 occurs years (M= 18.24 years, SD = 1.258). The main conclusions of this research is drawn that about one in ten are students who intend to study the three degrees of a foreign language is in the University (Grade of English Studies, Translation and Interpretation and Primary Mention Foreign …