Search results for "GUT"

Post-Classical Islamic Philosophy – a Contradiction in Terms?

2020

This paper engages critically with Dimitri Gutas’ recent characterization of post-classical Islamic philosophy and theology as a form of paraphilosophy or intellectual activity that merely simulates philosophy. I argue that this view arises from a misguided understanding of the concept of philosophy that should provide the standard for its historiography. In order to avoid a number of problematic consequences, such as gaps in historical continuity or a disconnection from what we understand by philosophy today, we must take our cue from a sufficiently uncontroversial contemporary concept of philosophy instead of any particular historical concept, such as the Peripatetic amalgam of metaphysic…

CoproID predicts the source of coprolites and paleofeces using microbiome composition and host DNA content

2020

Shotgun metagenomics applied to archaeological feces (paleofeces) can bring new insights into the composition and functions of human and animal gut microbiota from the past. However, paleofeces often undergo physical distortions in archaeological sediments, making their source species difficult to identify on the basis of fecal morphology or microscopic features alone. Here we present a reproducible and scalable pipeline using both host and microbial DNA to infer the host source of fecal material. We apply this pipeline to newly sequenced archaeological specimens and show that we are able to distinguish morphologically similar human and canine paleofeces, as well as non-fecal sediments, fro…

Postnatal developmental changes in the dopaminergic signaling in mouse gut

2011

The presence of dopamine-containing neurons in the enteric nervous system has been described, but it is far to be clear their role in the modulation of gut motility. Moreover, ontogenetic studies shows that dopaminergic neurons are late-developing neurons, arising perinatally, but there are no informations if dopaminergic signaling may undergo to developmental changes after birth, as demonstrated for other signaling. Thus, using a pharmacological approach, we examined, in vitro, the role of dopaminergic neurons in the regulation of duodenal contractility in neonatal mice (≤48 h postnatal) compared to the adults. Transcripts for all dopaminergic receptors were detected in mouse duodenum at e…

Dopaminergic signaling in mouse duodenum and postanatal developmental changes

2012

Kroppsbilde og slankefokus blant fysisk aktive gutter i ungdomsskolen og på videregående skole i Norge :

2016

Masteroppgave i idrettsvitenskap - Universitetet i Agder 2016 The aim of this study was to investigate body image and drive for thinness among adolescent boys, and to examine variations for these variables in age and level of physical activity. This cross-sectional study is part of “the Relevance of Physical Activity Contexts in Every-Day Life of Adolescents” (REPAC), which is a larger project. 1423 boys from secondary school (8th grade) and upper secondary school (11th grade) were included in this study, and these responded to a questionnaire that was developed to examine how different activity contexts affected adolescent boys everyday lives. Correlation analysis and one-way ANOVA tests w…

IBD, malignancy and oral microbiota: Analysis of the literature

2016

The human microbiota, in adults, varies in number and species based on the location in the gastrointestinal tract. The highest concentration is at the intestinal level, where mainly Bacteroidetes, Actinobacteria, Firmicutes and proteobacteria are found. Instead, in the oral cavity, five major phyla exists. Firmicutes, Actinobacteria, Proteobacteria, Bacteroidetes and Fusobacteria. Variations in the microbiota cause bysbiosis, which is responsible to a great extent for the onset of many diseases including inflammatory bowel disease (IBD) and colorectal cancer (CRC). In some cases (8-10%) IBD has shown oral manifestations that may reflect a change in the composition of the oral microbiota. Th…

The influence of some dietary components on intestinal microbiota

2016

The gut microbiota is the set of symbiotic microorganisms that resides in our intestine. The interaction between the gut microbiota and the mucosal immune system can be altered as a result of shifts in the composition or metabolic activity of the intestinal microflora. Recent studies establish that diet is one of the main involved factors in determining the microbial composition of the gut suggesting its role as external factor able to promote the onset of specific diseases by disrupting the immune homeostasis. Starting from the evidence that the 57% of the gut microbiota’s entire variation are due to dietary alterations this review aims at providing an overview of the positive impact of so…

Binding of Insecticidal Crystal Proteins of Bacillus thuringiensis to the Midgut Brush Border of the Cabbage Looper, Trichoplusia ni (Hübner) (Lepido…

1994

The susceptibility of Trichoplusia ni larvae to several Bacillus thuringiensis insecticidal crystal proteins (ICPs) was tested. Neonatal larvae proved to be susceptible to solubilized trypsin-treated CryIA(a), CryIA(b), and CryIA(c) (50% lethal concentrations [LC 50 s], 570, 480, and 320 ng/cm 2 , respectively) but showed little susceptibility to CryIB and CryID (LC 50 s, 5,640 and 2,530 ng/cm 2 , respectively). The toxicity of ICPs was correlated to binding to the epithelial brush border of the midgut, as revealed by immunocytochemical staining with monoclonal antibodies. In vitro binding experiments with iodinated ICPs and brush border membrane vesicles indicated that CryIA(b) and CryIA(…

Targeting antibiotic resistant bacteria with phages reduces bacterial density in an insect host

2018

Phage therapy is attracting growing interest among clinicians as antibiotic resistance continues becoming harder to control. However, clinical trials and animal model studies on bacteriophage treatment are still scarce and results on the efficacy vary. Recent research suggests that using traditional antimicrobials in concert with phage could have desirable synergistic effects that hinder the evolution of resistance. Here, we present a novel insect gut model to study phage-antibiotic interaction in a system where antibiotic resistance initially exists in very low frequency and phage specifically targets the resistance bearing cells. We demonstrate that while phage therapy could not reduce th…

Functional interactions between members of the REPAT family of insect pathogen-induced proteins

2012

Studies on the transcriptional response to pathogens in the insect larval gut have shown the regulation of several genes after the infection. Repat (REsponse to PAThogens) genes were first identified in Spodoptera exigua midgut as being up-regulated in response to the exposure to Bacillus thuringiensis toxins and baculovirus. Recently, new members of the REPAT family showed a constitutive up-regulation in a B. thuringiensis-resistant population. Based on a yeast two-hybrid screening, we have detected the interaction of REPAT1 with other members of the REPAT family, leading to the discovery of a new member: REPAT8. The functional role of this interaction was shown by following the changes of…