Search results for "Gable"

showing 10 items of 10 documents

An overview of recent molecular dynamics applications as medicinal chemistry tools for the undruggable site challenge

2018

Molecular dynamics (MD) has become increasingly popular due to the development of hardware and software solutions and the improvement in algorithms, which allowed researchers to scale up calculations in order to speed them up. MD simulations are usually used to address protein folding issues or protein-ligand complex stability through energy profile analysis over time. In recent years, the development of new tools able to deeply explore a potential energy surface (PES) has allowed researchers to focus on the dynamic nature of the binding recognition process and binding-induced protein conformational changes. Moreover, modern approaches have been demonstrated to be effective and reliable in …

0301 basic medicinePharmacologyVirtual screeningDrug discoveryComputer scienceOrganic ChemistryRational designPharmaceutical ScienceComputational biologyBiochemistrySmall moleculeSettore CHIM/08 - Chimica FarmaceuticaChemistry03 medical and health sciencesMolecular dynamics030104 developmental biology0302 clinical medicineDocking (molecular)030220 oncology & carcinogenesisDrug DiscoveryMolecular MedicineProtein foldingPharmacophoreMolecular Dynamics undruggable target computational studies
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Último adiós a Vidal-Beneyto. El sociólogo fue enterrado ayer en Carcaixent, su localidad natal

2010

ComplutenseVidal-Beneyto JoséCarcaixentEspañaInfatigableOpositorAdiósPolíticaSobre José Vidal-Beneyto: Necrológicas y referencias póstumasAmelaAntifranquistaCatedráticoJOSÉ VIDAL-BENEYTOPepínLe Monde DiplomatiqueValenciaCiudadano del mundoPaco IbáñezEuropaEuropeístaSociólogoParís
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La esperanza crítica

2010

CulturaCombate políticoMúnichVidal-Beneyto JoséPolíticaSobre José Vidal-Beneyto: Necrológicas y referencias póstumasComplicidadContubernioMemoria democráticaMilitanteEl PaísMultidisciplinarEsperanza críticaInteligenciaImprescindibleDerechoCríticoInfatigableTransformaciónTransiciónCombate intelectualAnalistaIntelectualBrillante trayectoria académicaJOSÉ VIDAL-BENEYTOPepínEuropaSociologíaCHEE
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The visual query language CQL for transitive and relational computation

2000

Abstract Classification query language (CQL) is a high-level visual query language with a great expressive power. In CQL the processing of ordinary relations and classifications based on transitive relationships is integrated seamlessly. Relations and classifications are represented in the visual interface in a uniform way through relation and classification skeletons. All query formulation in CQL is QBE-like – based on the intuitive way of filling constants and sample values into the skeletons. In order to guarantee great expressive power, relational and classification expressions can be nested freely with each other at unlimited nesting levels. Recursive definition of transitive processin…

Information Systems and Managementbusiness.industryComputer scienceQuery languagecomputer.software_genreQuery optimizationQuery expansionObject Query LanguageWeb query classificationSargableQuery by ExampleArtificial intelligencebusinesscomputerNatural language processingRDF query languagecomputer.programming_languageData & Knowledge Engineering
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Memorial José Vidal Beneyto

2010

MúnichVidal-Beneyto JoséHeterogeneidadEspañaÉticaPalabraSolidaridadSueños utópicosPolíticaNecrológicaSobre José Vidal-Beneyto: Necrológicas y referencias póstumasContubernioCaminoJusticiaMemoriaAntifranquismoUniversidadComplutenseIdeologíasInfatigableTransiciónInterlocutoresPensamiento complejoUNESCOJOSÉ VIDAL-BENEYTOPepínAltermundialismoEuropaCarlos BerzosaEdgar Morin
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Optimisation des requêtes de similarité dans les espaces métriques répondant aux besoins des usagers

2012

The complexity of data stored in large databases has increased at very fast paces. Hence, operations more elaborated than traditional queries are essential in order to extract all required information from the database. Therefore, the interest of the database community in similarity search has increased significantly. Two of the well-known types of similarity search are the Range (Rq) and the k-Nearest Neighbor (kNNq) queries, which, as any of the traditional ones, can be sped up by indexing structures of the Database Management System (DBMS). Another way of speeding up queries is to perform query optimization. In this process, metrics about data are collected and employed to adjust the par…

Similarity algebraMetric spacesRequêtes de similaritéSpeedupTheoretical computer science[ MATH.MATH-GM ] Mathematics [math]/General Mathematics [math.GM]Nearest neighbor searchL'intérêt des usagersSearch engine indexingInformationSystems_DATABASEMANAGEMENTAlgèbre pour similarité[MATH.MATH-GM] Mathematics [math]/General Mathematics [math.GM]Espaces métriquesQuery optimizationSimilarity queriesUser's expectation[INFO.INFO-OH] Computer Science [cs]/Other [cs.OH]Metric spaceSimilarity (network science)Search algorithm[ INFO.INFO-OH ] Computer Science [cs]/Other [cs.OH]SargableOptimisation des requêtes de similaritéMathematicsSimilarity query optimization
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José Vidal Beneyto, o la impaciencia apasionada

2010

SocialismoOpus DeiMúnichVidal-Beneyto JoséHonoris CausaCiencias SocialesSobre José Vidal-Beneyto: Necrológicas y referencias póstumasContubernioNaranjeroValencianoDinamismoImpacienciaMerleau-PontyLucha políticaInfatigableApasionadaIdiomasCatolicismoFeCEISAJOSÉ VIDAL-BENEYTOPepínJunta DemocráticaInvestigaciónValenciaSociologíaParísEnseñanzaCHEE
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Dos inscripciones sobre la fundación de Lara y una sobre sus siete infantes, con un análisis evolutivo de su iglesia parroquial

2016

Se someten a crítica filológica e histórica tres inscripciones epigráficas procedentes de Lara de los Infantes que abordan el discutido tema del origen de Castilla. La factura de la más antigua, encontrada en la ermita de San Julián (en el Museode Burgos desde principios del siglo XX) se debió de redactar a mediados del siglo XII, en sintonía con el monasterio burgalés de San Pedro de Arlanza, pues resalta la preeminencia de este centro en su vínculo con Fernán González. Posiblemente se basó también en una tradición local lareña hoy perdida y, en todo caso, partiendo de noticias espurias. En época humanística, antes del año 1600, se realizó una copia de esta inscripción a la que se añadió o…

UNESCO::CIENCIAS DE LAS ARTES Y LAS LETRASHistoryEpigraphy; Romanesque; forgeries; medieval copywriting; Fernán González; counts of Castile; origins of Castile; AusinaLiterature and Literary TheoryGableFilologíasmedia_common.quotation_subjectOtras filologías modernasArtAncient historyMaking-ofStructural evolutionUnknown SourcePhilology:CIENCIAS DE LAS ARTES Y LAS LETRAS [UNESCO]media_commonMagnificat Cultura i Literatura Medievals
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Towards Graphical Query Notation for Semantic Databases

2015

We describe a notation and a tool for schema-enabled visual/diagrammatic creation of SPARQL queries over RDF databases. The notation and the tool support both the standard basic query pattern comprising a main query class and possibly linked condition classes and means for aggregate query definition and placing conditions over aggregates including also aggregation of aggregate results. We discuss the applicability of the tool for ad-hoc query formulation in practical use cases.

Web search queryInformation retrievalComputer scienceInformationSystems_INFORMATIONSTORAGEANDRETRIEVALAggregate (data warehouse)InformationSystems_DATABASEMANAGEMENTcomputer.file_formatQuery languageQuery optimizationNotationSPARQLSargableQuery by Examplecomputercomputer.programming_language
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Post-search query modeling in federated web scenario

2014

As opposed to query reformulation oriented towards changes made by a user to specify the information need more precisely, a post-search query modeling is a technique of exploiting syntax variation of gradually extended query which depending on some other factors like e.g. the resource, database or the key word alignment, facilitates the searching process. The study into modeling query submitted to some search engines that utilize different translation semantic paradigms is motivated by a real-world's challenges to retrieve heterogeneous textual documents from the web. For a couple of language pairs, we develop a user-centered framework for imposing the Hidden Web traffic optimization. In li…

Web search queryInformation retrievalComputer scienceQuery languageQuery optimizationRanking (information retrieval)Human-Computer InteractionQuery expansionWeb query classificationcomponentSearch StrategyHidden WebSargableQuery ModelingTrans-lingual Information RetrievalcomputerRDF query languagecomputer.programming_languageThe Fifth International Conference on the Applications of Digital Information and Web Technologies (ICADIWT 2014)
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