Search results for "Gare"

Apparent transinhibition of peptide uptake in the scutellum of barley grain

1985

The uptake of glycylsarcosine (Gly‐Sar) into scutella separated from germinating grains of barley (Hordeum vulgare L. cv. Himalaya) is inhibited by other peptides; in most cases the inhibition is not purely competitive but of a mixed type (simultaneous increase in the apparent Km and decrease in Vmax) (Sopanen, T. 1979. FEBS Lett. 108: 447–450). The aim of the present experiments was to elucidate the mechanism of the mixed inhibition by studying how peptides already taken up into the cells affect the uptake of Gly‐Sar. When scutella were preincubated in the presence of various peptides, 11 of the 13 peptides tested inhibited the subsequent uptake of Gly‐Sar by 10 to 45%. The inhibition, stu…

The Health Risks of Electronic Cigarettes Use in Adolescents

2020

The evidence to date suggests that vaping is not a safe alternative to smoking tobacco. This, coupled with the worrying trend of young nonsmokers being attracted to vaping, raises fears of yet another generation suffering from chronic lung disease and other acute and chronic health conditions. Finally, due to the insufficient regulations in several countries, up-to-date data on the prevalence of e-cigarette use and studies on the health's implications of their use are urgently needed to inform policy at a national and international level (ie, European Union). Pediatricians are typically on the front line for identifying emerging risks for children and adolescents ; therefore, they may effec…

The Lady Half-Devoured by a Dragon and the Iconography of Saint Margaret of Antioch : Interpreting an Anonymous Invención in the Cancionero general (…

2018

Following in the footsteps of Ian Macpherson, I offer an interpretation of an anonymous invención found in the Cancionero general (11CG-517) and the British Library Cancionero (LB1-251). I maintain that the image displayed by the jouster was inspired by the iconography of the virgin-martyr Saint Margaret of Antioch, and I propose a theory about the identity of the lady addressed and, with less certainty, about the identity of the jouster and the occasion when the invención was displayed, using Pinar’s Juego trobado as a tool of research and invoking a passage on the sinfulness of the fashion among ladies and damsels for wearing hooped petticoats in a treatise by Hernando de Talavera.

Human HSP10 variants downregulation after cigarette smoke extract exposure in lung cells

2009

The impact of cigarette-smoke stress (a form of oxidative stress) on human lung fibroblasts and epithelial cells, particularly its effect on Hsp10 expression, has not been characterized despite the fact that a role for mitochondrial chaperonins in the development of lung diseases, ranging from chronic obstructive pulmonary disease to bronchial carcinogenesis, has been suggested (1). We studied the effects of non-lethal doses of cigarette smoke extract (CSE) on the expression of Hsp10 in human lung fibroblasts (HFL-1 line) and epithelial cells (16HBE line). Proteomics was carried out using 2D-IPG, silver stain, western blotting, and mass-spectrometry; mRNA was measured by RT-PCR. Database se…

Jälleenrakentamisen ajan lapsesta tulevaisuuden lapseen : suomalaisten lastenkirjojen lapsikäsitykset ja sosiologinen lapsitutkimus

1998

Dažādu smēķēšanas veidu izvēles raksturojums Rīgas izglītības iestādēs

2021

Par maģistra darba mērķi izvirzījām noskaidrot, kādi ir aktuālie smēķēšanas ieradumi Rīgas izglītības iestādēs. Par maģistra darba uzdevumiem izvirzījām noskaidrot, kādas smēķēšanas metodes izvēlas skolnieki un studenti no 15 gadu vecuma, kā viņi izturas pret esošajiem smēķēšanas ierobežojumiem, kāda ir attieksme pret jaunajām tabakas lietošanas iespējām un kas varētu veicināt šī negatīvā ieraduma atmešanu, lai uzlabotu Latvijas iedzīvotāju kopējo veselības līmeni. Pētījumā noskaidrojām, ka jaunieši uzsāk smēķēšanu 10-20 gadu vecumā, pirmajā smēķēšanas reizē izvēloties cigaretes. Svarīgākie smēķēšanu veicinošie faktori ir problēmas mācībās/studijās, emocionālās problēmas un spriedze. Vairāk…

Riflessioni e traiettorie di ricerca interdisciplinari sulla transizione digitale

2022

The contribution introduces the topic covered by vol. 12 of AGATHÓN through essays, studies, research and projects on Innovability©® | Digital Transition to investigate the current widespread transformation that unites dichotomies (analogue and digital), enhances oxymorons (artificial intelligence), creates paradoxes (materiality of the intangible), while indiscriminately involving architecture, humanities and social sciences, anthropology, sociology, ecology, biology, physical-mathematical sciences and neurosciences, with impacts that – while already visible today and accelerated in part by the extraordinary global health emergency – will become even more evident in the medium and long ter…

Il divieto di "caccia all’errore" nelle gare, previsto dall’art. 46, comma 1 bis, del codice degli appalti.

2011

The impact of cigarette smoking on the health of descendants

2012

This paper presents a review of the literature on the effects of cigarette smoking on the health of descendants and the possible mechanisms that lead to them. The evidence of the effects of prenatal cigarette smoke exposure on neonatal morbidity is clear. A number of birth defects have their incidence raised by maternal cigarette smoking during pregnancy. Prenatal smoke exposure also increases the risk of infant irritability, inattention, decreased response to inanimate auditory stimuli and hypertonia. In addition, the prevalence of obesity in preschool children is higher if the mother smoked during pregnancy, as well as the presence of male or female subfertility/infertility in adult life.…

Cigarette smoke promotes inflammasome‐independent activation of caspase‐1 and ‐4 leading to gasdermin D cleavage in human macrophages

2022

Mechanisms and consequences of gasdermin D (GSDMD) activation in cigarette smoke (CS)-associated inflammation and lung disease are unknown. GSDMD is a downstream effector of caspase-1, -8, and -4. Upon cleavage, GSDMD generates pores into cell membranes. Different degrees of GSDMD activation are associated with a range of physiological outputs ranging from cell hyperactivation to pyroptosis. We have previously reported that in human monocyte-derived macrophages CS extract (CSE) inhibits the NLRP3 inflammasome and shifts the response to lipopolysaccharide (LPS) towards the TLR4-TRIF axis leading to activation of caspase-8, which, in turn, activates caspase-1. In the present work, we investig…