Search results for "Gating"
showing 10 items of 108 documents
Attraction d'ondes pour des systèmes à résonance d'ondes contra-propagatives
2011
Wave attraction in counter-propagating waves systems is a general phenomenon that was first established in Physics in the context of the attraction of the polarization between two counter-propagating waves in optical fibers. This phenomenon has been observed experimentally, and its properties were studied through numerical simulations. The models are Hamiltonian hyperbolic systems of partial differential equations, with time-dependent boundary conditions on a finite interval. The underlying mechanism can be traced back to the existence of singular tori in the corresponding stationary equations. In this work we analyze in detail the simplest example in this family of models. We show that mos…
Sensitivity of SHG-FROG for the characterization of ultrahigh-repetition-rate telecommunication laser sources
2004
International audience; We analyze experimentally the sensitivity of second-harmonic generation frequency-resolved optical gating (SHG-FROG) for the complete intensity and phase characterization of both a sinusoidal beat signal and a train of 1.3 ps pulses at a repetition rate of 160 GHz at 1550 nm. Using a commercially-available optical spectrum analyzer in the SHG-FROG set-up, incident pulses with energies of only 125 and 190 fJ, which correspond to the beat signal and the 1.3 ps pulse train, respectively, have been accurately characterized.
Carbohydrate-Mediated Biomolecular Recognition and Gating of Synthetic Ion Channels
2013
Nanochannel-based biosensing devices have been proposed for selective detection of protein analyte molecules. However, the design and miniaturization of reusable channel-based biosensors is still a challenge in nanoscience and biotechnology. We present here a reusable nanofluidic biosensor based on reversible lectin-carbohydrate interactions. The nanochannels are fabricated in heavy ion tracked polymer membranes. The channel walls are functionalized with p-aminophenyl alpha-D-mannopyranoside (APMP) monolayers through carbodiimide coupling chemistry. The chemical (mannopyranoside) groups on the inner channel walls serve as binding sites and interact with specific protein molecules. The bindi…
Stellenwert der Spirometertriggerung für die hochauflösende Computertomographie der Lunge in Inspiration und Exspiration
1998
PURPOSE To compare mean lung density (MLD) of paired inspiratory and expiratory thin-section CT scans acquired after patient instruction or using spirometric gating. MATERIALS AND METHODS 21 patients (13 m, 8 f. median age 59 years, two with normal lung function, 15 with obstructive, 4 with restrictive impairment) underwent thin-section CT. Paired inspiratory and expiratory scans were performed in the upper, middle and lower lung fields. They were acquired after automatic patient instruction with constant intervals between instruction and scan. Spirometrically gated scans were acquired within 4 days at 80% and 20% of vital capacity (VC) which has been determined on the CT scanner in supine …
NECAB2 participates in an endosomal pathway of mitochondrial stress response at striatal synapses
2021
Synaptic signaling depends on ATP generated by mitochondria. Due to extensive connectivity, the striatum is especially vulnerable to mitochondrial dysfunction and thus requires efficient mitochondrial quality control. We found that the neuronal calcium-binding protein NECAB2 ensures synaptic function in the striatum by increasing mitochondrial efficiency. NECAB2 associates with early endosomes and mitochondria at striatal synapses. Loss of NECAB2 dysregulates proteins of the endosomal ESCRT machinery and oxidative phosphorylation. Mitochondria from NECAB2-deficient mice are more abundant but less efficient. These mitochondria exhibit increased respiration and superoxide production but produ…
Active Plasmonics in True Data Traffic Applications: Thermo-Optic On/Off Gating Using a Silicon-Plasmonic Asymmetric MachZehnder Interferometer
2012
We present the first system-level demonstration of an active plasmonic device in 10-Gb/s data traffic conditions. An asymmetric silicon-plasmonic Mach-Zehnder interferometer with dielectric-loaded plasmonic waveguides serving as the electrically controlled arms, operates as thermo-optic ON/OFF gating element with 2.8-mu s response time and 10.8-mW power consumption. We present the first system-level demonstration of an active plasmonic device in 10-Gb/s data traffic conditions. An asymmetric silicon-plasmonic Mach-Zehnder interferometer with dielectric-loaded plasmonic waveguides serving as the electrically controlled arms, operates as thermo-optic ON/OFF gating element with 2.8-mu s respon…
TAFA4 relieves injury-induced mechanical hypersensitivity through LDL receptors and modulation of spinal A-type K+ current
2021
Pain, whether acute or persistent, is a serious medical problem worldwide. However, its management remains unsatisfactory, and new analgesic molecules are required. We show here that TAFA4 reverses inflammatory, postoperative, and spared nerve injury (SNI)-induced mechanical hypersensitivity in male and female mice. TAFA4 requires functional low-density lipoprotein receptor-related proteins (LRPs) because their inhibition by RAP (receptor-associated protein) dose-dependently abolishes its antihypersensitive actions. SNI selectively decreases A-type K+ current (IA) in spinal lamina II outer excitatory interneurons (L-IIo ExINs) and induces a concomitant increase in IA and decrease in hyperpo…
Protein Kinase C-dependent Ubiquitination and Clathrin-mediated Endocytosis of the Cationic Amino Acid Transporter CAT-1*
2011
Cationic amino acid transporter 1 (CAT-1) is responsible for the bulk of the uptake of cationic amino acids in most mammalian cells. Activation of protein kinase C (PKC) leads to down-regulation of the cell surface CAT-1. To examine the mechanisms of PKC-induced down-regulation of CAT-1, a functional mutant of CAT-1 (CAT-1-HA-GFP) was generated in which a hemagglutinin antigen (HA) epitope tag was introduced into the second extracellular loop and GFP was attached to the carboxyl terminus. CAT-1-HA-GFP was stably expressed in porcine aorthic endothelial and human epithelial kidney (HEK) 293 cells. Using the HA antibody internalization assay we have demonstrated that PKC-dependent endocytosis…
Counter-propagating frequency mixing with Terahertz waves in diamond
2013
Frequency conversion by means of Kerr nonlinearity is one of the most common and exploited nonlinear optical processes in the UV, visible, IR, and mid-IR spectral regions. Here we show that wave mixing of an optical field and a terahertz wave can be achieved in diamond, resulting in the frequency conversion of the terahertz radiation either by sum- or difference-frequency generation. In the latter case, we show that this process is phase matched and most efficient in a counterpropagating geometry.