Search results for "Gee"
showing 10 items of 639 documents
Development of biotechnological tools for studying infectious pathways of canine and human parvoviruses
2005
Leona Gilbertin väitöskirjatyö antaa uutta tietoa parvovirusten pinnanmuokkauksesta ja hyödyllisyydestä virologian, geeniterapian ja biolääketieteen sovelluksissa. Parvovirukset ovat pieniä, yksisäikeistä DNA:ta sisältäviä eläinviruksia, jotka kykenevät infektoimaan isäntänsä soluja. Ihmisillä ne aiheuttavat ihottumaa sekä nivelkipuja. Tutkimuksessa tuotettiin bakuloviruksen avulla hyönteissoluissa sekä koiran että ihmisen parvoviruksen rakenneproteiineista fluoresloivia fuusioproteiineja. Selvisi, että parvoviruksen pinta sopii hyvin muokkaamiseen ja vieraiden molekyylien ilmentämiseen. Lisäksi havaittiin, että bakuloviruksia voidaan käyttää geeninsiirtovälineenä mm. parvovirusproteiinien …
Transport parameters for aroma compounds through i-carrageenan and sodium alginate-based edible films
2011
In an effort to produce more environmentally friendly materials, renewable and biodegradable biopolymers have been investigated as coating materials. Edible films obtained from i-carrageenan and sodium alginates have good mechanical characteristics, are emulsion stabilizers, and decrease oxygen transfer. The addition of lipids to form emulsified films decreases the water vapour transfer and could be used to encapsulate active substances or aroma compounds. The aim of this work was to measure permeability, sorption and diffusion coefficient of the n-hexanal and D-limonene aroma compounds through emulsified (wf) and non-emulsified (wof) i-carrageenan and sodium alginate-based films to finally…
Online Hate Does Not Stay Online – How Implicit and Explicit Attitudes Mediate the Effect of Civil Negativity and Hate in User Comments on Prosocial …
2020
Abstract Incivility and hateful language in user comments are met with growing concern among politicians, the general public, and scholars. There are fears that such comments may decrease social cohesion and ultimately result in less prosocial behavior among citizens. We investigate whether hate, or even civil negativity in user comments alone, inhibit actual prosocial behavior through recipients’ explicit and implicit attitudes. In an online experiment, 253 participants read user comments (neutral, civil-negative, hateful) about refugees and received five Euros which they could donate for a refugee aid organization or keep for themselves. The results show that participants confronted with …
Avidin engineering : modification of function, oligomerization, stability and structure topology
2003
Avidiini on neljästä samanlaisesta alayksiköstä muodostunut tetrameerinen glykoproteiini, jota esiintyy luontaisesti, pieninä pitoisuuksina, kanan munanvalkuaisessa. Eräs avidiinin merkittävimmistä ominaisuuksista on sen kyky sitoa vitamiini biotiinia. Avidiinin ja biotiinin välinen vuorovaikutus on voimakkain tunnettu luonnossa esiintyvä ei-kovalenttinen sidos proteiinin ja sen ligandin välillä. Tätä ominaisuutta on hyödynnetty jo pitkään lukuisissa bio- ja lääketieteellisissä sovelluksissa, jotka yhdessä muodostavat niin kutsutun (strept)avidiini-biotiini -teknologian. Avidin is a basic and rather stable tetrameric glycoprotein found in chicken egg-white. It has an enormous affinity towar…
Long-term leisure-time physical activity vs. inactivity, physical fitness, body composition and metabolic health characteristics : a co-twin control …
2013
No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Data…
2021
Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers of pathogenic changes in mismatch repair (MMR) genes have an increased risk of developing colorectal (CRC), endometrial, ovarian, urinary tract, prostate, and other cancers, depending on which gene is malfunctioning. In Lynch syndrome, differences in cancer incidence (penetrance) according to the gene involved have led to the stratification of cancer surveillance. By contrast, any differences in penetrance determined by the type of pathogenic variant remain unknown. Objective. To determine cumulative incidences of cancer in carriers of truncating and missense or aberrant splicing pathogenic …
STAT5b is a key effector of NRG-1/ERBB4-mediated myocardial growth
2023
The growth factor Neuregulin-1 (NRG-1) regulates myocardial growth and is currently under clinical investigation as a treatment for heart failure. Here, we demonstrate in several in vitro and in vivo models that STAT5b mediates NRG-1/EBBB4-stimulated cardiomyocyte growth. Genetic and chemical disruption of the NRG-1/ERBB4 pathway reduces STAT5b activation and transcription of STAT5b target genes Igf1, Myc, and Cdkn1a in murine cardiomyocytes. Loss of Stat5b also ablates NRG-1-induced cardiomyocyte hypertrophy. Dynamin-2 is shown to control the cell surface localization of ERBB4 and chemical inhibition of Dynamin-2 downregulates STAT5b activation and cardiomyocyte hypertrophy. In zebrafish e…
Studies of Nature of Uncommon Bifurcated I–I···(I–M) Metal-Involving Noncovalent Interaction in Palladium(II) and Platinum(II) Isocyanide Cocrystals
2021
Two isostructural trans-[MI2(CNXyl)2]·I2 (M = Pd or Pt; CNXyl = 2,6-dimethylphenyl isocyanide) metallopolymeric cocrystals containing uncommon bifurcated iodine···(metal–iodide) contact were obtained. In addition to classical halogen bonding, single-crystal X-ray diffraction analysis revealed a rare type of metal-involved stabilizing contact in both cocrystals. The nature of the noncovalent contact was studied computationally (via DFT, electrostatic surface potential, electron localization function, quantum theory of atoms in molecules, and noncovalent interactions plot methods). Studies confirmed that the I···I halogen bond is the strongest noncovalent interaction in the systems, followed …
Interactions of different hydrocolloids with milk proteins
2020
Abstract To control rheological properties and accomplish perfect sensory properties and mouthfeel, polysaccharides are added to milk-based beverages. However, in contrast to expectations, it is often found that adding low concentrations of xanthan gum or guar gum to milk provokes phase separations of unclear physical origin. From this observation, questions arise regarding the interaction of added polysaccharides and the proteins present in milk – caseins and whey proteins. The focus of this study is to investigate such systems and to understand the basic interactions of caseins and whey proteins with different hydrocolloids. The hydrocolloids used in this study are xanthan gum, guar gum, …
Halogen bond preferences of thiocyanate ligand coordinated to Ru(II) via sulphur atom
2017
Halogen bonding between [Ru(bpy)(CO)2(S-SCN)2] (bpy = 2,2’-bipyridine), I2 was studied by co-crystallising the metal compound and diiodine from dichloromethane. The only observed crystalline product was found to be [Ru(bpy)(CO)2(S-SCN)2]⋅I2 with only one NCS⋅⋅⋅I2 halogen bond between I2 and the metal coordinated S atom of one of the thiocyanate ligand. The dangling nitrogen atoms were not involved in halogen bonding. However, computational analysis suggests that there are no major energetic differences between the NCS⋅⋅⋅I2 and SCN⋅⋅⋅I2 bonding modes. The reason for the observed NCS⋅⋅⋅I2 mode lies most probably in the more favourable packing effects rather than energetic preferences between …