Search results for "Gel"
showing 10 items of 3561 documents
Desarrollo y aplicaciones de hidrogeles para la aministración y liberación modificada de fármacos
2016
Los hidrogeles son redes poliméricas tridimensionales obtenidas a partir de polímeros hidrófilos que pueden hincharse en un medio acuoso sin disolverse. Estos sistemas presentan una serie de propiedades óptimas para su aplicación en el campo biomédico. De hecho, en las últimas décadas se han investigado, patentado y comercializado distintas composiciones basadas en hidrogeles como sistemas de liberación de fármacos, apósitos para heridas, etc. La versatilidad de los hidrogeles radica en que sus propiedades y, por tanto, sus posibles aplicaciones, pueden modificarse en función del tipo de entrecruzamiento (físico o químico), naturaleza del polímero, agente entrecruzante, tamaño del sistema (…
Síntesis y caracterización de scaffolds poliméricos para la ingeniería de tejidos
2013
El desarrollo del campo de la ingeniería de tejidos surge ante la necesidad de dar solución a las deficiencias asociadas a la sustitución de tejidos cuando se han producido pérdidas irreparables de los mismos o no funcionan correctamente. Muchos tipos de células necesitan scaffolds para guiar el desarrollo de nuevos tejidos con la función apropiada, servir como sustrato para la adhesión celular y al mismo tiempo proporcionar un soporte mecánico para el nuevo tejido que ha crecido. El objetivo principal de este trabajo ha sido desarrollar métodos de síntesis de scaffolds poliméricos, basados en el método convencional denominado colado de sólidos en combinación con el lixiviado de partículas,…
Two cases of monomicrobial intraabdominal abscesses due to KPC - 3 Klebsiella pneumoniaeST258 clone
2011
Abstract Background Knowledge of the etiology of pyogenic liver and pancreatic abscesses is an important factor in determining the success of combined surgical and antibiotic treatment. Literature shows geographical variations in the prevalence and distribution of causative organisms, and the spread of Klebsiella pneumoniae carbapenemase-producing bacteria is an emerging cause of abdominal infections. Case presentation We herein describe two cases of intra-abdominal abscesses due to monomicrobial infection by Klebsiella pneumoniae Sequence Type 258 producing K. pneumoniae carbapenemase 3 (KPC-Kp). In case 1, a 50-year-old HIV-negative Italian woman with chronic pancreatitis showed infection…
Il mondo visto da Los Angeles: il congresso annuale dell’AAG 2013
2013
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…
METHOD TO PRODUCE HYALURONIC ACID FUNCTIONALIZED DERIVATIVES AND FORMATION OF HYDROGELS THEREOF
2009
Positive effects of an extracellular matrix hydrogel on rat anterior cruciate ligament fibroblast proliferation and collagen mRNA expression
2015
Summary Background/Objective We have previously shown that an extracellular matrix (ECM) bioscaffold derived from porcine small intestine submucosa (SIS) enhanced the healing of a gap injury of the medial collateral ligament as well as the central third defect of the patellar tendon. With the addition of a hydrogel form of SIS, we found that a transected goat anterior cruciate ligament (ACL) could also be healed. The result begs the research question of whether SIS hydrogel has positive effects on ACL fibroblasts (ACLFs) and thus facilitates ACL healing. Methods In the study, ECM-SIS hydrogel was fabricated from the digestion of decellularised and sterilised sheets of SIS derived from αGal-…
Metronidazola kvantitatīvā noteikšana farmaceitiskā preparātā
2016
Metronidazola kvantitatīvā noteikšana farmaceitiskā preparātā. Lazdāne L., zinātniskais vadītājs Dr. Ķīm. Nakurte, I. Maģistra darbs, 54 lappuses, 23 attēli, 20 tabulas, 45 literatūras avoti, 2 pielikumi. Latviešu valodā. Veikts literatūras apkopojums par farmaceitiski aktīvo vielu metronidazolu un tā farmakoloģiskajām īpašībām. Noskaidrotas metronidazola ekstrakcijas un analītiskās noteikšanas metodes. Balstoties uz ICH vadlīnijām veikta metronidazola kvantitatīvās noteikšanas metodes Metronidazola 7,5 mg/g gelā validācija. Validācijas ietvaros noteikta hromatogrāfiskās metodes linearitāte, noteikšanas robežas, pareizība un precizitāte, atkārtojamība, robustums. Pārbaudīta metronidazola st…
Effects of fatiguing jumping exercise on mRNA expression of titin-complex proteins and calpains.
2009
Eccentric exercise induced by electrostimulation increases mRNA expression of titin-complex proteins in rodent skeletal muscle. In this study, mRNA expression of titin, muscle LIM protein (MLP), cardiac ankyrin repeat protein (CARP), ankyrin repeat domain protein 2 (Ankrd2), diabetes-related ankyrin repeat protein (DARP), and calcium-activated proteinases, calpains, were investigated in human skeletal muscle after fatiguing jumping exercise. Fatiguing jumping exercise did not change mRNA expression of titin, DARP, calpain 1, or calpain 3. MLP, Ankrd2 and calpain 2 mRNA levels were increased 2 days postexercise. CARP mRNA level was already elevated 30 min and remained elevated 2 days postexe…
Monolītiska silīcija dioksīda iegūšana ar sola-gela metodi
2021
Darbā pilnveidota SiO2 sola-gela sintēzes metode ar mērķi iegūt monolītiskus, optiski caurspīdīgus, nesaplaisājušus paraugus. SiO2 paraugu konsolidācijas process pētīts, tos pakāpeniski izkarsējot gaisā, skābeklī vai ūdeņradī. SiO2 paraugu īpašību pētījumos izmantotas struktūranalīzes, termogravimetrijas, optiskās spektroskopijas un elektronu mikroskopijas metodes. Darbā iegūts stiklveida monolītisks SiO2, pie termiskās apstrādes temperatūrām 600 °C un augstākām. Sintezētajos paraugos novērota palielināta 3-locekļu SiO2 saišu gredzenu koncentrācija, kā arī brīvās un ar ūdeņraža saiti saistītās silanolgrupas (Si-O-H). Silanolgrupu koncentrāciju iespējams samazināt, karsējot paraugu 1000 °C –…