Search results for "General Mathematics"

Revisiting the didactic triangle: from the particular to the general

2012

Published version of an article in the journal: ZDM. Also available from the publisher at: http://www.springerlink.com/content/61p78l089tnx8rn5/ The basic notion of a didactic triangle is explained with historical annotations on its origins and subsequent theorization in the literature. Instances of its application to classroom environments to demonstrate its representational capabilities are presented. Generalizations of the triangle are proposed that integrate the role of technology, the researcher in mathematics teaching developmental research, and mediating complexes in the student–teacher–content interfaces. Further, the use of the didactic triangle as a heuristic device is also discus…

Spectral Clustering Reveals Different Profiles of Central Sensitization in Women with Carpal Tunnel Syndrome

2021

Identification of subgroups of patients with chronic pain provides meaningful insights into the characteristics of a specific population, helping to identify individuals at risk of chronification and to determine appropriate therapeutic strategies. This paper proposes the use of spectral clustering (SC) to distinguish subgroups (clusters) of individuals with carpal tunnel syndrome (CTS), making use of the obtained patient profiling to argue about potential management implications. SC is a powerful algorithm that builds a similarity graph among the data points (the patients), and tries to find the subsets of points that are strongly connected among themselves, but weakly connected to others.…

Why Does COVID-19 Case Fatality Rate Vary Among Countries?

2020

SummaryBackgroundWhile the epidemic of SARS-CoV-2 is spreading worldwide, there is much concern over the mortality rate that the infection induces. Available data suggest that COVID-19 case fatality rate varies temporally (as the epidemic progresses) and spatially (among countries). Here, we attempted to identify key factors possibly explaining the variability in case fatality rate across countries.MethodsWe used data on the temporal trajectory of case fatality rate provided by the European Center for Disease Prevention and Control, and country-specific data on different metrics describing the incidence of known comorbidity factors associated with an increased risk of COVID-19 mortality at …

Absence of CCR3 receptor accelerates atherosclerosis in apoE-/- mice

2018

4-Manifold topology II: Dwyer's filtration and surgery kernels

1995

Even when the fundamental group is intractable (i.e. not "good") many interesting 4-dimensional surgery problems have topological solutions. We unify and extend the known examples and show how they compare to the (presumed) counterexamples by reference to Dwyer's filtration on second homology. The development brings together many basic results on the nilpotent theory of links. As a special case, a class of links only slightly smaller than "homotopically trivial links" is shown to have (free) slices on their Whitehead doubles.

What Do We Really Know about the Effectiveness of Glaucoma Interventions?

2021

Purpose To identify systematic reviews of interventions for glaucoma conditions and to assess their reliability, thereby generating a list of potentially reliable reviews for updating glaucoma practice guidelines. Design Cross-sectional study. Participants Systematic reviews of interventions for glaucoma conditions. Methods We used a database of systematic reviews and meta-analyses in vision research and eye care maintained by the Cochrane Eyes and Vision United States Satellite. We examined all Cochrane systematic reviews of interventions for glaucoma conditions published before August 7, 2019, and all non-Cochrane systematic reviews of interventions for glaucoma conditions published betwe…

Should overactive bladder symptoms be reported as means or medians? An exploratory study with propiverine

2018

Community detection-based deep neural network architectures: A fully automated framework based on Likert-scale data

2020

[EN] Deep neural networks (DNNs) have emerged as a state-of-the-art tool in very different research fields due to its adaptive power to the decision space since they do not presuppose any linear relationship between data. Some of the main disadvantages of these trending models are that the choice of the network underlying architecture profoundly influences the performance of the model and that the architecture design requires prior knowledge of the field of study. The use of questionnaires is hugely extended in social/behavioral sciences. The main contribution of this work is to automate the process of a DNN architecture design by using an agglomerative hierarchical algorithm that mimics th…

A randomised, placebo-controlled phase 3 study to evaluate the efficacy and safety of ASP0113, a DNA-based CMV vaccine, in seropositive allogeneic ha…

2021

BACKGROUND: Cytomegalovirus (CMV) is a complication of allogeneic haematopoietic cell transplantation (allo-HCT). ASP0113, a DNA-based vaccine, contains two plasmids encoding human CMV glycoprotein B and phosphoprotein 65 (pp65). We assessed ASP0113 in CMV-seropositive allo-HCT recipients. METHODS: In this phase 3, randomised, placebo-controlled study, CMV-seropositive allo-HCT recipients were randomly assigned (1:1) via interactive response technology to receive five injections of 1 mL of 5 mg/mL ASP0113 or placebo. The pharmacist and designated staff were unblinded. Masked syringes maintained the blind for patients and study personnel. Efficacy and safety analyses included patients who re…

Mathematical Modeling for Neuropathic Pain: Bayesian Linear Regression and Self-Organizing Maps Applied to Carpal Tunnel Syndrome

2020

A better understanding of the connection between risk factors associated with pain and function may assist therapists in optimizing therapeutic programs. This study applied mathematical modeling to analyze the relationship of psychological, psychophysical, and motor variables with pain, function, and symptom severity using Bayesian linear regressions (BLR) and self-organizing maps (SOMs) in carpal tunnel syndrome (CTS). The novelty of this work was a transfer of the symmetry mathematical background to a neuropathic pain condition, whose symptoms can be either unilateral or bilateral. Duration of symptoms, pain intensity, function, symptom severity, depressive levels, pinch tip grip force, a…