Search results for "Generalized linear mixed model"
showing 10 items of 31 documents
A recap on Linear Mixed Models and their hat-matrices
2017
This working paper has a twofold goal. On one hand, it provides a recap of Linear Mixed Models (LMMs): far from trying to be exhaustive, this first part of the working paper focusses on the derivation of theoretical results on estimation of LMMs that are scattered in the literature or whose mathematical derivation is sometimes missing or too quickly sketched. On the other hand, it discusses various definitions that are available in the literature for the hat-matrix of Linear Mixed Models, showing their limitations and proving their equivalence.
Geographical variation in pharmacological prescription
2009
Promoting rational drug administration in treatments is one of the most important issues in Public Health. Bayesian hierarchical models are a very useful tool for incorporating geographical information into the analysis of pharmacological prescription data. They allow the mapping of spatial components which express the trend of geographical variation. In addition, these models are able to deal with uncertainty in a sequential way through prior distributions on parameters and hyperparameters. Bayes' theorem combines all types of information and provides the posterior distribution which is computed through Markov Chain Monte Carlo (MCMC) simulation methods. Simulated data for pharmacological …
Removing Batch Effects from Longitudinal Gene Expression - Quantile Normalization Plus ComBat as Best Approach for Microarray Transcriptome Data
2016
International audience; Technical variation plays an important role in microarray-based gene expression studies, and batch effects explain a large proportion of this noise. It is therefore mandatory to eliminate technical variation while maintaining biological variability. Several strategies have been proposed for the removal of batch effects, although they have not been evaluated in large-scale longitudinal gene expression data. In this study, we aimed at identifying a suitable method for batch effect removal in a large study of microarray-based longitudinal gene expression. Monocytic gene expression was measured in 1092 participants of the Gutenberg Health Study at baseline and 5-year fol…
"a priori" Dietary Patterns and Cognitive Function in the SUN Project
2019
<b><i>Objectives:</i></b> To study and compare associations of 5 dietary patterns – Mediterranean dietary pattern (MDP), Dietary Approaches to Stop Hypertension (DASH), Mediterranean-DASH Intervention for Neurodegenerative delay (MIND), Alternative Healthy Eating Index (AHEI-2010), and a pro-vegetarian diet (PVD) – with cognitive function. <b><i>Patients and Methods:</i></b> A subgroup of 806 participants from the “Seguimiento Universidad de Navarra”(SUN) cohort of university graduates, &#x3e;55 years old, was interviewed with the validated Spanish Telephone Interview for Cognitive Status (STICS-m) at baseline and after 2 and 6 years. For …
Bayesian joint models for longitudinal and survival data
2020
This paper takes a quick look at Bayesian joint models (BJM) for longitudinal and survival data. A general formulation for BJM is examined in terms of the sampling distribution of the longitudinal and survival processes, the conditional distribution of the random effects and the prior distribution. Next a basic BJM defined in terms of a mixed linear model and a Cox survival regression models is discussed and some extensions and other Bayesian topics are briefly outlined.
The geography of Spanish bank branches
2014
This article analyzes the determinants of bank branch location in Spain taking the role of geography explicitly into account. After a long period of intense territorial expansion, especially by savings banks, many of these firms are now involved in merger processes triggered off by the financial crisis, most of which entail the closing of many branches. However, given the contributions of this type of banks to limit financial exclusion, this process might exacerbate the consequences of the crisis for some disadvantaged social groups. Related problems such as new banking regulation initiatives (Basel III), or the current excess capacity in the sector add further relevance to this problem. We…
On Rao Score and Pearson X2 Statistics in Generalized Linear Models
2005
The identity of the Rao score and PearsonX 2 statistics is well known in the areas where the latter was first introduced: goodness-of-fit in contingency tables and binary responses. We show in this paper that the same identity holds when the two statistics are used for testing goodness-of-fit of Generalized Linear Models. We also highlight the connections that exist between the two statistics when they are used for the comparison of nested models. Finally, we discuss some merits of these unifying results.
Analyzing environmental‐trait interactions in ecological communities with fourth‐corner latent variable models
2021
In ecological community studies it is often of interest to study the effect of species related trait variables on abundances or presence-absences. Specifically, the interest may lay in the interactions between environmental and trait variables. An increasingly popular approach for studying such interactions is to use the so-called fourth-corner model, which explicitly posits a regression model where the mean response of each species is a function of interactions between covariate and trait predictors (among other terms). On the other hand, many of the fourth-corner models currently applied in the literature are too simplistic to properly account for variation in environmental and trait resp…
Subject-specific odds ratios in binomial GLMMs with continuous response
2007
In a regression context, the dichotomization of a continuous outcome variable is often motivated by the need to express results in terms of the odds ratio, as a measure of association between the response and one or more risk factors. Starting from the recent work of Moser and Coombs (Odds ratios for a continuous outcome variable without dichotomizing, Statistics in Medicine, 2004, 23, 1843-1860), in this article we explore in a mixed model framework the possibility of obtaining odds ratio estimates from a regression linear model without the need of dichotomizing the response variable. It is shown that the odds ratio estimators derived from a linear mixed model outperform those from a binom…
Modeling Posidonia oceanica growth data: from linear to generalized linear mixed models
2010
The statistical analysis of annual growth of Posidonia oceanica is traditionally carried out through Gaussian linear models applied to untransformed, or log-transformed, data. In this paper, we claim that there are good reasons for re-considering this established practice, since real data on annual growth often violate the assumptions of Gaussian linear models, and show that the class of Generalized Linear Models (GLMs) represents a useful alternative for handling such violations. By analyzing Sicily PosiData-1, a real dataset on P. oceanica growth data gathered in the period 2000–2002 along the coasts of Sicily, we find that in the majority of cases Normality is rejected and the effect of …