Search results for "Generation"

The business elite in Finland: a prosopographical study of family firm executives 1762–2010

2015

This study presents a prosopographical analysis of the Finnish business elite. The longitudinal panel dataset includes 456 members of family firms from 1762–2010 who have received the honorary title of counsellor in Finland. Counsellor biographies have been written by an economic history association network of 130 historians. Most family firms are no longer elite after the third generation of the family business or the second counsellor generation; therefore, the same core families rarely remain part of the economic elite for more than 100 years.

A metaphysical approach to holobiont individuality: Holobionts as emergent individuals

2019

Holobionts are symbiotic assemblages composed by a host plus its microbiome. The status of holobionts as individuals has recently been a subject of continuous controversy, which has given rise to two main positions: on the one hand, holobiont advocates argue that holobionts are biological individuals; on the other, holobiont detractors argue that they are just mere chimeras or ecological communities, but not individuals. Both parties in the dispute develop their argu-ments from the framework of the philosophy of biology, in terms of what it takes for a ?conglomerate? to be considered an interesting individual from a biological point of view. However, the debates about holobiont individualit…

Cellular responses and HSP70 expression during wound healing in Holothuria tubulosa (Gmelin, 1788).

2014

Wound repair is a key event in the regeneration mechanisms of echinoderms. We studied, at the behavioural, cellular and molecular levels, the wound healing processes in Holothuria tubulosa after injuries to the body wall. The experiments were performed for periods of up to 72 h, and various coelomocyte counts, as well as the expression of heat shock proteins (HS27, HSP70 and HSP90), were recorded. Dermal wound healing was nearly complete within 72 h. In the early stages, we observed the injured animals twisting their bodies to keep their injuries on the surface of the water for the extrusion of the buccal pedicles. At the cellular level, we found time-dependent variations in the circulating…

Observational Study of Antibiotic Usage at the Children’s Clinical University Hospital in Riga, Latvia

2018

Background and objectives: Many pediatric patients have been treated with antibiotics during their hospitalization. There is a need to improve antibiotic prescribing for pediatric patients because many of these prescriptions are inappropriate. Antibiotic consumption analysis was conducted at the Children&rsquo

Mild Heat Stress Enhances Angiogenesis in a Co-culture System Consisting of Primary Human Osteoblasts and Outgrowth Endothelial Cells

2013

The repair and regeneration of large bone defects, including the formation of functional vasculature, represents a highly challenging task for tissue engineering and regenerative medicine. Recent studies have shown that vascularization and ossification can be stimulated by mild heat stress (MHS), which would offer the option to enhance the bone regeneration process by relatively simple means. However, the mechanisms of MHS-enhanced angiogenesis and osteogenesis, as well as potential risks for the treated cells are unclear. We have investigated the direct effect of MHS on angiogenesis and osteogenesis in a co-culture system of human outgrowth endothelial cells (OECs) and primary osteoblasts …

Modelling, Identification and Control of a 5-DOF Shotcrete Robot : Development of a Framework for Automatic Application of Shotcrete for AMV 4200H

2019

Master's thesis Mechatronics MAS500 - University of Agder 2019 Today, process automation is the primary area of development in the shotcrete industry. Automaticshotcrete operations can yield an increase in operational efficiency and personnel safety as well asreductions in cost and environmental impact. This thesis develops a framework for automaticapplication of shotcrete using the AMV 4200H and provides an automatic spraying mode usinginteroceptive sensing. The shotcrete vehicle is equipped with a five degrees-of-freedom manipulatorand is currently operated manually. Our contributions include solving the forward kinematicsthrough the Denavit-Hartenberg convention, and the inverse kinemati…

AAV Vector–mediated RNAi of Mutant Huntingtin Expression Is Neuroprotective in a Novel Genetic Rat Model of Huntington's Disease

2008

We report the characterization of a new rapid-onset model of Huntington's disease (HD) generated by adeno-associated virus (AAV) vector–mediated gene transfer of N-terminal huntingtin (htt) constructs into the rat striatum. Expression of exon 1 of mutant htt containing 70 CAG repeats rapidly led to neuropathological features associated with HD. In addition, we report novel data relating to neuronal transduction of AAV vectors that modulated the phenotype observed in this model. Quantitative reverse transcriptase–polymerase chain reaction (RT–PCR) revealed that AAV vector–mediated expression in the striatum increased by >100-fold as compared to the endogenous htt level. Moreover, AAV vectors…

Landslides as Important Disturbance Regimes — Causes and Regeneration

2008

Concise review of interrill erosion studies in SE Spain (Alicante and Murcia): erosion rates and progress of knowledge from the 1980s

2005

From the 1980s onward studies on interrill soil erosion were intensified in SE Spain. The main achievements of the research carried out in the field areas of Alicante and Murcia concern: first, (1) the estimation of erosion rates directly in the field under a wide range of methodologies, different scales and different environmental conditions; (2) estimations based on existing models, such as the USLE, carried out for different subcatchments of the Segura and Júcar catchments; and (3) other parametric and physical event-based models have also been calibrated and validated. Second, the progress of the knowledge in understanding erosion mechanisms. New and reviewed concepts regarding mainly h…

Analysis of soil surface component patterns affecting runoff generation. An example of methods applied to Mediterranean hillslopes in Alicante (Spain)

2008

Spatial patterns of soil surface components (vegetation, rock fragments, crusts, bedrock outcrops, etc.) are a key factor determining hydrological functioning of hillslopes. A methodological approach to analyse the patterns of soil surface components at a detailed scale is proposed in this paper. The methods proposed are applied to two contrasting semi-arid Mediterranean hillslopes, and the influence of soil surface component patterns on the runoff response of the slopes was analysed. A soil surface components map was derived from a high resolution photo-mosaic obtained in the field by means of a digital camera. Rainfall simulation experimental data were used to characterise the hydrologica…