Search results for "Generation"
showing 10 items of 3050 documents
Reawakening the sleeping beauty in the adult brain: neurogenesis from parenchymal glia
2015
Life-long neurogenesis is highly restricted to specialized niches in the adult mammalian brain and therefore the brain's capacity for spontaneous regeneration is extremely limited. However, recent work has demonstrated that under certain circumstances parenchymal astrocytes and NG2 glia can generate neuronal progeny. In the striatum, stroke or excitotoxic lesions can reawaken in astrocytes a latent neurogenic program resulting in the genesis of new neurons. By contrast, in brain areas that fail to mount a neurogenic response following injury, such as the cerebral cortex, forced expression of neurogenic reprogramming factors can lineage convert local glia into induced neurons. Yet, injury-in…
FRET based ratiometric Ca(2+) imaging to investigate immune-mediated neuronal and axonal damage processes in experimental autoimmune encephalomyeliti…
2015
Abstract Background Irreversible axonal and neuronal damage are the correlate of disability in patients suffering from multiple sclerosis (MS). A sustained increase of cytoplasmic free [Ca2+] is a common upstream event of many neuronal and axonal damage processes and could represent an early and potentially reversible step. New method We propose a method to specifically analyze the neurodegenerative aspects of experimental autoimmune encephalomyelitis by Forster Resonance Energy Transfer (FRET) imaging of neuronal and axonal Ca2+ dynamics by two-photon laser scanning microscopy (TPLSM). Results Using the genetically encoded Ca2+ sensor TN-XXL expressed in neurons and their corresponding axo…
Identification of inflammatory neuronal injury and prevention of neuronal damage in multiple sclerosis: hope for novel therapies?
2013
Importance Although multiple sclerosis (MS) has long been considered the prototype for an inflammatory, demyelinating disease of the central nervous system, modern histopathology and imaging techniques show that significant damage to neuronal structures already start occurring in the earliest stages of the disease. As the disease progresses, the extent of neuronal pathology accumulates. Therapeutic progress in terms of the prevention of increased disability has only just begun. Objective To review possible diagnostic improvements of neuronal compartment pathology as well as direct therapeutic interventions based on reports from the last decade and outline clinical results from studies and p…
Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis.
1998
In the human brain and spinal cord, neurons degenerate after acute insults (e.g., stroke, cardiac arrest, trauma) and during progressive, adult-onset diseases [e.g., amyotrophic lateral sclerosis, Alzheimer's disease]. Glutamate receptor-mediated excitotoxicity has been implicated in all of these neurological conditions. Nevertheless, effective approaches to prevent or limit neuronal damage in these disorders remain elusive, primarily because of an incomplete understanding of the mechanisms of neuronal death in in vivo settings. Therefore, animal models of neurodegeneration are crucial for improving our understanding of the mechanisms of neuronal death. In this review, we evaluate experimen…
Neurogenesis in adult subventricular zone
2002
Much excitement has been generated by the identification of adult brain regions harboring neural stem cells and their continual generation of new neurons throughout life. This is an important departure from traditional views of the germinal potential of the postnatal brain. However, a more profound
Parental effects in a filamentous fungus : Phenotype, fitness and mechanism
2023
AbstractAdaptation to changing environments often requires meaningful phenotypic modifications to match the current conditions. However, obtaining information about the surroundings during an organism’s own lifetime may only permit accommodating relatively late developmental modifications. Therefore, it may be advantageous to rely on inter-generational or trans-generational cues that provide information about the environment as early as possible to allow development along an optimal trajectory. Transfer of information or resources across generations, known as parental effects, is well documented in animals and plants but not in other eukaryotes, such as fungi. Understanding parental effects…
General anaesthetics and the developing brain: an overview
2014
Various experimental studies in animals have shown that general anaesthetics are potentially toxic to the developing brain. By inducing apoptosis or interfering with neurogenesis, anaesthetic exposure during a critical period of neuronal development can have significant impact on neurocognitive function later in life. It remains controversial whether these experimental results can be transferred to human beings and this is under intensive scientific evaluation. To gain more insight into possible neurotoxic effects on the human brain of infants and small children, a number of retrospective studies have been performed. At present, there is no clear evidence that exposure to anaesthesia up to …
Mildronate and its neuroregulatory mechanisms: targeting the mitochondria, neuroinflammation, and protein expression.
2013
This review for the first time summarizes the data obtained in the neuropharmacological studies of mildronate, a drug previously known as a cardioprotective agent. In different animal models of neurotoxicity and neurodegenerative diseases, we demonstrated its neuroprotecting activity. By the use of immunohistochemical methods and Western blot analysis, as well as some selected behavioral tests, the new mechanisms of mildronate have been demonstrated: a regulatory effect on mitochondrial processes and on the expression of nerve cell proteins, which are involved in cell survival, functioning, and inflammation processes. Particular attention is paid to the capability of mildronate to stimulate…
'Climbing Untrodden Paths and Unfrequented Passes'. De-Generation in 'The Buddhist Priest's Wife' by Schreiner, 'A Cross Line' by Egerton and 'The Un…
2013
This essay aims to show how different forms of de-generation in the social construction of fin de siècle female identity prove to be intentional instruments to defy conventional 19th century femininity and generate and circulate new female discoursivities in order to integrate forms of transgression into socially accepted behaviours. As critics have long argued the New Woman -the modern woman emerging from the disruption of the Angel in the House stereotype- has to be treated as a discursive process and a multilayered subject. The analysis of Schreiner’s “The Buddhist Priest’s Wife” (1891), Egerton’s “A Cross Line” (1893), and Grand’s “The Undefinable: A Fantasia” (1894), will highlight the…
Il Piano nazionale di ripresa e resilienza e le sue fonti: dinamiche dei processi normativi in tempo di crisi
2022
Il libro descrive ed opera un'analisi critica del quadro normativo Euro-nazionale nell'ambito del quale è stato definito il Piano nazionale di ripresa e resilienza italiano (PNRR). Oggetto principale dell'analisi è l'impatto del quadro normativo UE nell'ambito del quale è stato sviluppato Next Generation EU ed, in particolare, il Dispositivo sulla ripresa e la resilienza, sul sistema delle fonti che caratterizza l'ordinamento costituzionale italiano. Sono prese in esame, in particolare le "misure legislative" previste dal piano, il sistema di indicatori di valutazione delle stesse per verificare se è stata data "soddisfacente" attuazione al Piano e le prassi attuative. The book gives an ove…