Search results for "Generation"
showing 10 items of 3050 documents
Thrombin generation - a potentially useful biomarker of thrombotic risk in Philadelphia-negative myeloproliferative neoplasms.
2017
The diagnosis of essential thrombocythemia and polycythemia vera is often made during a thrombotic event which can be serious. Philadelphia-negative chronic myeloproliferative neoplasia patients have an increased thrombotic risk. This is assessed using various scoring systems but these are far from ideal and individual risk. The currend trend to personalised medicine requires finding the most useful thrombotic risk biomarker in these patients. Routine tests for coagulation do not take account of both pro- and anti-coagulant factors which is why these tests are not useful in patients with Philadelphia-negative myeloproliferative neoplasms. Thrombin generation reflects more accurately the bal…
Tumor mutational burden on cytological samples: A pilot study.
2020
Background Immune-checkpoint inhibitors (ICIs) represent an important treatment option for patients who have advanced stage non-small cell lung cancer (NSCLC). Currently, evaluation of the expression level of programmed death-ligand 1 (PD-L1) has proven highly successful as a positive predictive biomarker for ICIs. In addition to PD-L1, other promising predictive biomarkers are emerging, including high tumor mutational burden (TMB-H). However, measuring TMB-H remains challenging for several reasons, among which is the difficulty in obtaining adequate tissue material from NSCLC patients. There are no data in the current literature regarding the possibility of adopting cell blocks (CBs) for T…
The presence of genomic imbalances is associated with poor outcome in patients with burkitt lymphoma treated with dose-intensive chemotherapy includi…
2015
Part of this study has been reported as an oral presentation at the EHA Meeting in Vienna 2015.
Heterogeneity of KRAS, NRAS, BRAF and PIK3CA mutations in metastatic colorectal cancer and potential effects on therapy in the CAPRI GOIM trial
2015
Background: Evidence suggests that metastatic colorectal carcinoma (mCRC) has a high level of intratumor heterogeneity. We carried out a quantitative assessment of tumor heterogeneity for KRAS, NRAS, BRAF and PIK3CA mutations, in order to assess potential clinical implications. Patients and methods: Tumor samples (n = 182) from the CAPRI-GOIM trial of first-line cetuximab + FOLFIRI in KRAS exon-2 wild-type mCRC patients were assessed by next-generation sequencing that allows quantitative assessment of mutant genes. Mutant allelic frequency was normalized for the neoplastic cell content and, assuming that somatic mutations usually affect one allele, the Heterogeneity Score (HS) was calculate…
Clinical Applications, Pitfalls, and Uncertainties of Thrombin Generation in the Presence of Platelets
2019
Platelet-dependent thrombin generation is a helpful tool to assess ex vivo the interaction between platelets and plasma coagulation factors in the initiation, amplification, and inhibition of thrombin generation (TG). This review article discusses the most relevant available data on the clinical applications of fluorogenic TG, the most widely used TG assay, performed in the presence of platelets, i.e., in platelet-rich plasma. With respect to prothrombotic states, arterial hypertension and obesity were the most prominent cardiovascular conditions linked to increased platelet-dependent TG. In addition, platelet-associated hypercoagulability, assessed by the TG assay, has been shown in indivi…
Deciphering Multiple Sclerosis Progression
2021
Esclerosi múltiple; Neurodegeneració Esclerosis múltiple; Neurodegeneración Multiple sclerosis; Nneurodegeneration Multiple sclerosis (MS) is primarily an inflammatory and degenerative disease of the central nervous system, triggered by unknown environmental factors in patients with predisposing genetic risk profiles. The prevention of neurological disability is one of the essential goals to be achieved in a patient with MS. However, the pathogenic mechanisms driving the progressive phase of the disease remain unknown. It was described that the pathophysiological mechanisms associated with disease progression are present from disease onset. In daily practice, there is a lack of clinical, ra…
Abstract 147: The Role of Thrombin Generation in Cardiovascular Disease and Mortality - Results from the Population-based Gutenberg Health Study
2018
Background: Thrombin formation is one of the key enzymatic processes that direct the activity of the hemostatic system. Thrombin generation (TG), a method addressing the overall potential of a given plasma sample to form thrombin, may be a potential tool to improve risk stratification for cardiovascular diseases (CVD). This study aims to explore the relation between TG and cardiovascular risk factors (CVRFs), CVD, and total mortality. Methods: For this study, N=5000 subjects from the population-based Gutenberg Health Study were analyzed in a highly standardized setting. TG was measured by the Calibrated Automated Thrombogram method at 1 and 5 pM tissue factor (TF) trigger in platelet poor …
The Big Meaning of Small Messages: The Use of WhatsApp in Intergenerational Family Communication
2018
This study explores the use of WhatsApp instant messenger in extended families in two countries, Finland and Italy, that represent different family and communication cultures. Qualitative research material was collected in 2014/2015 from families consisting of three or more generations and living either in the same or different households. A directed approach to qualitative content analysis was applied in the analysis of the research data. The results of the study show that WhatsApp is considered to facilitate family interaction across generations. The success of WhatsApp in the family context accounts for two main factors: first, for the possibility to reach the whole family at once; and s…
Reklāmas ietekme uz jaunās paaudzes patērētāju uzvedību Uzbekistānā
2022
Pētījuma mērķis ir izpētīt patērētāju uztveri, attieksmi un atbildi uz tiešsaistes reklāmām Uzbekistānā. Lai sasniegtu pētījuma mērķi, tika izstrādāta strukturēta anketa un ar izlases palīdzību tika apkopotas 200 respondentu no Uzbekistānas atbildes. Tika konstatēts, ka tiešsaistes reklāma ir noderīga respondenta atbilstoša lēmuma par pirkumu pieņemšanai, kā arī tiešsaistes reklāma pozitīvi ietekmē patērētāja pirkšanas tendences. Tika noskaidrots, ka reakciju uz tiešsaistes reklāmu spēcīgāk prognozē patērētāja attieksme nekā patērētāju uztvere par reklāmu tiešsaistē. Rezultāti liecina par to, ka uzņēmumiem, kas veicina produktu pārdošanu ar tiešsaistes reklāmām, ir jācenšas sasniegt potenci…
Synchronicity matters: defining the characteristics of digital generations
2015
This paper investigates whether or not the proposition that the second digital generation (or so-called digital natives) is more engaged in social use of the Internet than older generations is tenable. By analysing nationally representative questionnaire-based survey data collected from Finland in 2011 (N = 612), the study shows that rather than social use of the Internet in general, it is the synchronicity of online communication that distinguishes user generations. Results show that, in contrast to asynchronous modes of online communication (e.g. social networking sites, blogs and online discussion forums), synchronous modes (e.g. instant messaging and Internet calls) are clearly generati…