Search results for "Generation"

Performance evaluation of a multisource renewable power converter prototype

2014

Integration of distributed energy systems in micro-grid architecture for making a virtual power plant

2015

This paper presents a novel concept for increasing the penetration level of distributed renewable energy systems into the main electricity grid. When increasing the renewable energy penetration, it is important to implement the frequency based power delivery in distributed generators and work as traditional synchronous generators. This can be achieved by improving the power processing unit of each renewable generation units to work as active generators. But in existing grid architecture, the grid frequency is controlled as one common variable over the electricity grid. With such a method, it is difficult to use frequency based power sharing in small distributed generators and participate in…

Identification of predictive biomarkers for the efficacy of nivolumab in patients with advanced non-small cell cancer.

2019

The recent introduction of immunotherapy has disrupted the management of non-small cell lung cancer (NSCLC). Nivolumab, an antibody targeting the immune checkpoint inhibitor PD-1, has shown remarkable results in seconde-line setting after failure of standard first-line chemotherapy. However, only a quarter of patients benefits from this therapy. To date, no predictive biomarker of the therapeutic efficacy of nivolumab has been identified in a clear and consensual manner. The research for predictive biomarkers of efficacy or resistance to this treatment is, therefore, a major challenge.The emergence of high-throughput sequencing over the past decade has had a significant impact on clinical a…

Synthesis of fluorinated first generation starburst molecules containing a triethanolamine core and 1,2,4-oxadiazoles

2006

Abstract 5-Pentafluorophenyl-1,2,4-oxadiazoles, differently substituted at C(3), have been synthesized and used to functionalize the aliphatic primary hydroxyl functionalities of triethanolamine, under mild conditions. UV–visible absorption and emission spectra are reported, for both tri- and difunctionalised molecules, showing their potential applications as light-emitters in optoelectronic devices.

The number of maximal subgroups and probabilistic generation of finite groups

2020

[EN] In this survey we present some significant bounds for the number of maximal subgroups of a given index of a finite group. As a consequence, new bounds for the number of random generators needed to generate a finite d-generated group with high probability which are significantly tighter than the ones obtained in the paper of Jaikin-Zapirain and Pyber (Random generation of finite and profinite groups and group enumeration, Ann. Math., 183 (2011) 769-814) are obtained. The results of Jaikin-Zapirain and Pyber, as well as other results of Lubotzky, Detomi, and Lucchini, appear as particular cases of our theorems.

De Novo prion aggregates trigger autophagy in skeletal muscle

2014

ABSTRACT In certain sporadic, familial, and infectious prion diseases, the prion protein misfolds and aggregates in skeletal muscle in addition to the brain and spinal cord. In myocytes, prion aggregates accumulate intracellularly, yet little is known about clearance pathways. Here we investigated the clearance of prion aggregates in muscle of transgenic mice that develop prion disease de novo . In addition to neurodegeneration, aged mice developed a degenerative myopathy, with scattered myocytes containing ubiquitinated, intracellular prion inclusions that were adjacent to myocytes lacking inclusions. Myocytes also showed elevated levels of the endoplasmic reticulum chaperone Grp78/BiP, su…

High efficiency and clinical relevance of exome sequencing in the daily practice of neurogenetics

2021

ObjectiveTo assess the efficiency and relevance of clinical exome sequencing (cES) as a first-tier or second-tier test for the diagnosis of progressive neurological disorders in the daily practice of Neurology and Genetic Departments.MethodsSixty-seven probands with various progressive neurological disorders (cerebellar ataxias, neuromuscular disorders, spastic paraplegias, movement disorders and individuals with complex phenotypes labelled ‘other’) were recruited over a 4-year period regardless of their age, gender, familial history and clinical framework. Individuals could have had prior genetic tests as long as it was not cES. cES was performed in a proband-only (60/67) or trio (7/67) st…

Generating students' information seeking questions in the scholar lab: what benefits can we expect from inquiry teaching approaches?

2013

ABSTARCT: Physics teachers use experimental devices to show students how scientific concepts, principles, and laws are applied to understand the real world. This paper studies question generation of secondary and under-graduate university students when they are confronted with experimental devices in different but usual teaching situations: reading about devices while studying still images or diagrams, watching an experimental demonstration, and handling the devices in the laboratory. The influence of the prior scientific knowledge on the questions asked is also analysed. Inquiry learning environments, involving lab projects, seemed to stimulate more inferences addressed to causality when s…

Modelling and optimization of modular system for power generation from a salinity gradient

2019

Abstract Pressure retarded osmosis has been proposed for power generation from a salinity gradient resource. The process has been promoted as a promising technology for power generation from renewable resources, but most of the experimental work has been done on a laboratory size units. To date, pressure retarded osmosis optimization and operation is based on parametric studies performed on laboratory scale units, which leaves a gap in our understanding of the process behaviour in a full-scale modular system. A computer model has been developed to predict the process performance. Process modelling was performed on a full-scale membrane module and impact of key operating parameters such as h…

Simulation of a regeneration plant for spent pickling solutions via spray roasting

2015

Nowadays, pyrohydrolysis techniques are widely applied for regeneration of spent pickling liquors providing an excellent environmental and economical strategy to the problem of waste disposal/recovery, also thanks to the high acid recovery efficiencies (>99%) achieved1. In fact, in these processes, iron chlorides are converted into iron oxides and hydrogen chloride at high temperature in spray roasting or fluidized bed reactors2. Though the state-of-the-art technologies have been successfully applied only to large scale plants, the development of small scale units, able to perform a delocalized regeneration of spent solutions where these latter are actually produced, would be strongly ne…