Search results for "Generation"
showing 10 items of 3050 documents
RESVEGA, a Nutraceutical Omega-3/Resveratrol Supplementation, Reduces Angiogenesis in a Preclinical Mouse Model of Choroidal Neovascularization
2021
Age-related macular degeneration (AMD) is an eye disease that is characterized by damage to the central part of the retina, the macula, and that affects millions of people worldwide. At an advanced stage, a blind spot grows in the center of vision, severely handicapping patients with this degenerative condition. Despite therapeutic advances thanks to the use of anti-VEGF, many resistance mechanisms have been found to accentuate the visual deficit. In the present study, we explored whether supplementation with Resvega®, a nutraceutical formulation composed of omega-3 fatty acids and resveratrol, a well-known polyphenol in grapes, was able to counteract laser-induced choroidal neovascularizat…
THE “SALT-TASTING” NEWBORN
2021
Pseudohypoaldosteronism type 1 (PHA1) is a rare genetic disease due to the peripheral resistance to aldosterone. Clinical spectrum with neonatal onset includes salt loss, hyponatremia, hypochloraemia, hyperkalaemia, metabolic acidosis and increased plasmatic levels of aldosterone. Two forms of the disease - renal and systemic – have been described, which are genetically distinct and with wide clinical expressivity. The most severe generalized PHA1 is caused by mutations in the genes encoding for the subunits of the epithelial sodium channels (ENaC). The paper reports the case of a newborn of the first pregnancy of healthy and consanguineous Sicilian parents, with a clinical and hormonal pic…
Domain Generation Algorithm Detection Using Machine Learning Methods
2018
A botnet is a network of private computers infected with malicious software and controlled as a group without the knowledge of the owners. Botnets are used by cybercriminals for various malicious activities, such as stealing sensitive data, sending spam, launching Distributed Denial of Service (DDoS) attacks, etc. A Command and Control (C&C) server sends commands to the compromised hosts to execute those malicious activities. In order to avoid detection, recent botnets such as Conficker, Zeus, and Cryptolocker apply a technique called Domain-Fluxing or Domain Name Generation Algorithms (DGA), in which the infected bot periodically generates and tries to resolve a large number of pseudorando…
Study on the Effects of Pseudorandom Generation Quality on the Performance of Differential Evolution
2011
Experiences in the field of Monte Carlo methods indicate that the quality of a random number generator is exceedingly significant for obtaining good results. This result has not been demonstrated in the field of evolutionary optimization, and many practitioners of the field assume that the choice of the generator is superfluous and fail to document this aspect of their algorithm. In this paper, we demonstrate empirically that the requirement of high quality generator does not hold in the case of Differential Evolution.
Considerations on correlations in shift-register pseudorandom number generators and their removal
1997
Abstract We present a simple calculation quantitatively explaining the triplet correlations in the popular shift-register random number generator “R250”, which were recently observed numerically by Schmid and Wilding, and are known from general analysis of this type of generator. Starting from these considerations, we discuss various methods to remove these correlations by combining different shift-register generators. We implement and test a particularly simple and fast version, based on an XOR combination of two independent shift-register generators with different time lags. The results indicate that this generator has much better statistical properties than R250, while being only a facto…
On the Influence of PRNGs on Data Distribution
2012
The amount of digital information produced grows rapidly and constantly. Storage systems use clustered architectures designed to store and process this information efficiently. Their use introduces new challenges in storage systems development, like load-balancing and data distribution. A variety of randomized solutions handling data placement issues have been proposed and utilized. However, to the best of our knowledge, there has not yet been a structured analysis of the influence of pseudo random number generators (PRNGs) on the data distribution. In the first part of this paper we consider Consistent Hashing [1] as a combination of two consecutive phases: distribution of bins and distrib…
Migration history and risk of psychosis: results from the multinational EU-GEI study.
2022
The European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) Project was funded by grant agreement Health-F2-2010-241909 (Project EU-GEI) from the European Community’s Seventh Framework programme.
Enhancing Urban Brownfield Regeneration to Pursue Sustainable Community Outcomes through Dynamic Performance Governance
2019
This paper discusses the case of Puerto Madero (Buenos Aires, Argentina) to illustrate how the “Dynamic Performance Governance” framework is able to support policy networks to pursue sustainable community outcomes in urban brownfield regeneration. The case is an example of successful implementation of urban renewal carried out through a significant involvement of the private sector. It portrays a “financially-driven” governance mode which entails balancing the advantage of cash flow reinvestment for public services and infrastructure capacity development, with potential shortcomings in terms of social inclusion. Findings reveal two main trade-offs associated with policy design and implement…
Elderly Parents’ Need for Help and Adult Children's Moving Decisions
2015
Recent changes in Finnish welfare policies have increased the need for family involvement in eldercare. This article uses qualitative interviews to study working adult daughters’ reasons for moving in with their parent(s). Coresidence was linked to the parents’ need for support, but also to the daughters’ life situations, family histories, the availability of welfare services, and cultural norms and values. The interviewees used the “familist” and “independent life” discourses in their speech. The familist discourse was used to argue for coresidence as a natural continuation of family traditions and life history, whereas the independent life discourse was used to legitimize the need for alt…
CD34+ progenitor to endothelial cell transition in post-pneumonectomy angiogenesis.
2012
In many species, pneumonectomy triggers compensatory lung growth that results in an increase not only in lung volume, but also in alveolar number. Whether the associated alveolar angiogenesis involves the contribution of blood-borne progenitor cells is unknown. To identify and characterize blood-borne progenitor cells contributing to lung growth after pneumonectomy in mice, we studied wild-type and wild-type/green fluorescence protein (GFP) parabiotic mice after left pneumonectomy. Within 21 days of pneumonectomy, a 3.2-fold increase occurred in the number of lung endothelial cells. This increase in total endothelial cells was temporally associated with a 7.3-fold increase in the number of …