Search results for "Generation"

Improving the Techniques for Human Hepatocyte Transplantation: Report from a Consensus Meeting in London

2012

On September 6 and 7, 2009 a meeting was held in London to identify and discuss what are perceived to be current roadblocks to effective hepatocyte transplantation as it is currently practiced in the clinics and, where possible, to offer suggestions to overcome the blocks and improve the outcomes for this cellular therapy. Present were representatives of most of the active clinical hepatocyte transplant programs along with other scientists who have contributed substantial basic research to this field. Over the 2-day sessions based on the experience of the participants, numerous roadblocks or challenges were identified, including the source of cells for the transplants and problems with tra…

Clinico-Biomechanical Issues and Dynamic Stabilization When Considering Stem Cell Treatment for Degenerative Disc Disease

2013

After reading the article published in Transplantation (1), scientists are to be congratulatedVespecially with the clinical results as published. Looking for alternatives to avoid fusion is part of function-preserving spine care, as it should be the last option to be undertaken while keeping the debate open (2, 3). Nevertheless, we would like to point out some questions that arise from a clinical point of view from our daily surgical practice. First, several clinical presentations and procedures are compared without taking into account that they are different treatments applied for different disc disease situations (discectomy is performed for disc herniation with radicular symptoms, disc p…

Load Demand Analysis of Nordic Rural Area with Holiday Resorts for Network Capacity Planning

2019

Most of the Nordic holiday resorts are in rural area with low capacity distributed network. The rural area network is weak and needs capacity expansion planning as the load demand of this area are going to increase due to penetration of electric vehicles and heat pumps. Such type of rural network can also be operated as a micro-grid, and therefore load analysis is required for appropriate operation. The load analysis will also be useful for finding proper sizing of distributed energy resources including energy storage. In this work, load demand analysis of a typical Nordic holiday resorts, connected in rural grid, is presented to find out the load variation during the usage periods. The loa…

Infrastructure as Interface: Thinking the Urban and the High-speed Railway Station: Italian Case-studies

2013

The recent launching in Italy of a number of large scale urban operations centered around High Speed Railway (HSR) stations has added a wealth of examples and themes to the overall European picture; these go to make up a global point of reference for other countries that are, in this period, undertaking the construction of their own HSR networks. Above and beyond the territorial questions often linked to the issue, further research investigating the architectural aspect of these operations would be highly relevant, but is rather lacking. Instead, we shall be focusing on current HSR stations in Italy, such as Turin Porta Susa, Florence Belfiore and Rome Tiburtina, and comparing them briefly,…

Design of a transverse flux machine for power generation from seawaves

2014

In this paper, we present a transverse flux linear generator. We investigate the possibility to use this generator to extract energy from seawaves. We propose an optimization procedure that allows us to obtain an optimized design of the generator. The optimized design of the converter shows a power generation capability index much higher than other renewable systems.

Does granulocyte-colony stimulating factor stimulate peripheral nerve regeneration? An experimental study on traumatic lesion of the sciatic nerve in…

2021

Aim of the study. To analyse the therapeutic potential of granulocyte-colony stimulating factor (G-CSF) treatment using a rat model of traumatic sciatic nerve lesion. Clinical rationale for the study. G-CSF has proven strong neurotrophic properties in various models of ischaemic and traumatic brain injury. Fewer studies exist regarding the influence of G-CSF on posttraumatic peripheral nerve regeneration. Currently, the possibilities of pharmacological prevention or treatment of mechanical nerve injury are limited, and there is an urgent need to find new treatment strategies applicable in clinical situations. Material and methods . A controlled traumatic right sciatic nerve lesion was set u…

A multicentre randomized controlled trial on trans-generational attention deficit/hyperactivity disorder (ADHD) in mothers and children (AIMAC): an e…

2018

Abstract. Objective: We examined predictors and moderators of treatment outcome in mothers and children diagnosed with ADHD in a large multicentre RCT. Method: In total, 144 mother-child dyads with ADHD were randomly assigned to either a maternal ADHD treatment (group psychotherapy and open methylphenidate medication, TG) or to a control treatment (individual counselling without psycho- or pharmacotherapy, CG). After maternal ADHD treatment, parent-child training (PCT) for all mother-child dyads was added. The final analysis set was based on 123 dyads with completed primary outcome assessments (TG: n = 67, CG: n = 56). The primary outcome was the change in each child’s externalizing sympto…

Sonic Hedgehog-Mediated Synergistic Effects Guiding Angiogenesis and Osteogenesis

2012

Sonic hedgehog (Shh) is a morphogen controlling the skeletal and vascular development in the embryo but is also reactivated during adult repair processes. Thus, this molecule holds great therapeutic potential for biotechnological and biomedical approaches aiming to enhance tissue regeneration or to replace damaged tissues. According to present knowledge, Shh signaling controls the expression of several families of growth factors involved in neovascularization and vessel maturation and acts upstream of the most prominent angiogenic growth factor, vascular endothelial growth factor. In this context, a very interesting feature of Shh is that it controls both angiogenic activity and vessel stab…

Two-generation cardiovascular disease prevalence in familial hypercholesterolemia

2016

Framework for Evaluating the Version Management Capabilities of a Class of UML Modeling Tools from the Viewpoint of Multi-Site, Multi-Partner Product…

2010

UML models are widely used in software product line engineering for activities such as modeling the software product line reference architecture, detailed design, and automation of software code generation and testing. But in high-tech companies, modeling activities are typically distributed across multiple sites and involve multiple partners in different countries, thus complicating model management. Today's UML modeling tools support sophisticated version management for managing parallel and distributed modeling. However, the literature does not provide a comprehensive set of industrial-level criteria to evaluate the version management capabilities of UML tools. This article's contributio…