Search results for "Generation"

Evolutionary ecology of immune priming in the mealworm beetle, Tenebrio molitor

2017

Many organisms can improve their immune response as a function of their immunological experience, a phenomenon called immune priming. While the mechanisms through which immune priming is achieved remain unknown, individuals that survived to a given parasite are better protected against subsequent exposures. This immune priming can cross generations (trans-generational immune priming – TGIP), preparing offspring for prevailing parasite environment. Both individual and trans-generational immune priming might be adaptive and may have evolved from repeated challenges by the same pathogens during the host lifetime or across generation. While protection could be cross-reactive, a certain level of…

Expression Patterns of Key Hormones Related to Pea (Pisum sativum L.) Embryo Physiological Maturity Shift in Response to Accelerated Growth Conditions

2019

Protocols have been proposed for rapid generation turnover of temperate legumes under conditions optimized for day-length, temperature, and light spectra. These conditions act to compress time to flowering and seed development across genotypes. In pea, we have previously demonstrated that embryos do not efficiently germinate without exogenous hormones until physiological maturity is reached at 18 days after pollination (DAP). Sugar metabolism and moisture content have been implicated in the modulation of embryo maturity. However, the role of hormones in regulating seed development is poorly described in legumes. To address this gap, we characterized hormonal profiles (IAA, chlorinated auxin…

Straw mulch as a sustainable solution to decrease runoff and erosion in glyphosate-treated clementine plantations in Eastern Spain. An assessment usi…

2019

[EN] In many Mediterranean areas, citrus orchards exhibit high soil loss rates because of the expansion of drip irrigation that allows cultivation on sloping terrain and the widespread use of glyphosate. To mitigate these non-sustainable soil losses, straw mulch could be applied as an efficient solution but this has been poorly studied. Therefore, the main goal of this paper was to assess the use of straw mulch as a tool to reduce soil losses in clementine plantations, which can be considered representative of a typical Mediterranean citrus orchard. A total of 40 rainfall simulation experiments were carried out on 20 pairs of neighbouring bare and mulched plots. Each experiment involved app…

Proteomic analysis of sub-retinal deposits in age-related macular degeneration

2014

National audience

Role of Oxidative Stress in Aging of the Retina in the ApoB100,LDLR-/- Mouse, a Murine Model of Aging of the Human Retina

2009

Supplémentation en oméga 3 et approche clinique dans la DMLA

2015

The Crosstalk of Adipose-Derived Stem Cells (ADSC), Oxidative Stress, and Inflammation in Protective and Adaptive Responses

2020

International audience; The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs is a major goal in repair medicine. Stem cells are classified by their potential to differentiate into functional cells. Compared with other sources, adipose-derived stem cells (ADSCs) have the advantage of being abundant and easy to obtain. ADSCs are considered to be tools for replacing, repairing, and regenerating dead or damaged cells. The capacity of ADSCs to maintain their properties depends on the balance of complex signals in their microenvironment. Their properties and the associated outcomes are in part regulated by reactive oxygen species, which medi…

Genomic characterization of mosaic cutaneous pigmentary disorders

2019

Ntroduction: Mosaic cutaneous dyschromia is strongly evocative of an underlying genetic mosaicism. These post-zygotic events are challenging for conventional diagnostic tools. Thus, genetic basis of mosaic cutaneous dyschromia still remained poorly understood. Materials and Methods: The M.U.S.T.A.R.D. cohort gathers DNA from skin biopsies of patients with mosaic cutaneous dyschromia. After a specialised phenotype analysis, they are referred to either trio exome sequencing (ES) at 200X, or targeted ultra-deep sequencing (60,000X) of candidate genes. Data are analysed with a tailored pipeline, allowing detection of both low-rate nucleotidic variations or chromosomal events. Results: From 2013…

Neurophysiologic Testing in Infants With Usher Syndrome Type 1

2009

Purpose: Usher syndrome type 1 needs to be diagnosed at early age, when speech therapy and cochlear implantation can stimulate communication in a deaf child who will confront an additional visual handicap. Molecular diagnosis is not routinely available. Visual function tests are not easily performed in young children. Before the age of six years, progressive retinal degeneration does not always show fundoscopic changes and few data are available regarding neurophysiologic abnormalities. This study was designed to describe electroretinogram (ERG) and visual evoked potentials (VEP) in a series of fourteen children with Usher syndrome type I.Methods: Monocular ERG and binocular VEP were perfor…

Plasma omega 3 polyunsaturated fatty acids and macular pigment optical density in subjects at high risk for age-related macular degeneration: the Lim…

2016

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.; Purpose: In numerous epidemiological studies, omega 3 polyunsaturated fatty acids (PUFAs) have been associated with a decreased risk of age-related macular degeneration (AMD). Beyond their structural, functional and neuroprotective roles, omega 3 PUFAs may favor the retinal accumulation of lutein and zeaxanthin and thus increase macular pigment optical density (MPOD). We examined the associations of MPOD with plasma omega 3 PUFAs in subjects with at least one parent affected by neovascular AMD. Methods: The Limpia study is a double-blind, placebo controlled, prospective randomize…