Search results for "Generation"
showing 10 items of 3050 documents
Sensory neuropathy with bone destruction due to a mutation in the membrane-shaping atlastin GTPase 3.
2014
Many neurodegenerative disorders present with sensory loss. In the group of hereditary sensory and autonomic neuropathies loss of nociception is one of the disease hallmarks. To determine underlying factors of sensory neurodegeneration we performed whole-exome sequencing in affected individuals with the disorder. In a family with sensory neuropathy with loss of pain perception and destruction of the pedal skeleton we report a missense mutation in a highly conserved amino acid residue of atlastin GTPase 3 (ATL3), an endoplasmic reticulum-shaping GTPase. The same mutation (p.Tyr192Cys) was identified in a second family with similar clinical outcome by screening a large cohort of 115 patients …
A Laboratory Dust Generator Applying Vibration to Soil Sample: Mineralogical Study and Compositional Analyses
2020
International audience; A laboratory study was carried out using a vibrating system (SyGAVib) to produce aerosols from four soils collected in the central Tunisian region around Sfax. The aim of this device is to mimic dust emission by natural wind erosion. Using compositional analysis, the dust produced was compared to (i) dust generated in a wind tunnel by the same soils, (ii) fine sieved and (iii) original bulk soils, and (iv) naturally occurring aerosol samples collected in the same area. The relative quartz content strongly decreases from bulk to fine soils, and again from fine soils to both wind tunnel and vibration‐generated aerosols. Compositional data analysis (CoDA) clearly shows …
New European Wind Atlas: Microscale Atlas
2021
Wind Atlas layers from the New European Wind Atlas (NEWA) microscale atlas. The atlas was made by downscaling the NEWA mesoscale wind atlas using the Wind Atlas Analysis and Application Program (WAsP) microscale model.Data are accessible through doWIND, an instance of daTap (RESTfull API for data aggregation and subsetting)
High-order harmonic generation via bound-bound transitions in an elliptically polarized laser field
2016
We use a simplified five-level system to investigate the high-order harmonic generation (HHG) spectrum emitted by an atom driven by a linearly or elliptically polarized laser field. For this model, the Schrödinger equation is exactly analytically reduced to the system of ordinary differential equations, which is solved numerically. Studying the intensity and polarization of the emitted radiation, we find that under high laser ellipticity the harmonic emission is suppressed. However, the harmonic intensity typically depends nonmonotonously on the laser ellipticity. Such anomalous behavior is very pronounced for the resonant harmonic. We offer an explanation of this behavior based on the incr…
Spontaneous Cardiomyocyte Differentiation From Adipose Tissue Stroma Cells
2004
Cardiomyocyte regeneration is limited in adult life. Thus, the identification of a putative source of cardiomyocyte progenitors is of great interest to provide a usable model in vitro and new perspective in regenerative therapy. As adipose tissues were recently demonstrated to contain pluripotent stem cells, the emergence of cardiomyocyte phenotype from adipose-derived cells was investigated. We demonstrated that rare beating cells with cardiomyocyte features could be identified after culture of adipose stroma cells without addition of 5-azacytidine. The cardiomyocyte phenotype was first identified by morphological observation, confirmed with expression of specific cardiac markers, immunocy…
Optical Remote Sensing in Urban Environments
2016
International audience; Cities today face a variety of issues: attractiveness and economic development, living conditions and urban redevelopment, the quality of life of citizens and the environmental conditions of the urban system as a whole. These challenges reflect the situations in urban territories where the economic development and population growth required for stabilizing the urban system come into conflict with the promotion of esthetic urban improvements appropriate for social cohesion and ensuring the safety of users while guaranteeing a reduction of the environmental impact caused by urban spread [WGI 14, WEB 15, MAC 07, WIL 11]. The process of urbanization, which has significan…
An NDC approach to helping pensioners cope with the cost of long-term care
2018
The aim of this paper is to analyse whether it would be possible to provide retirement and long-term care benefits using the same unfunded notional defined contribution scheme. We extend the multi-state overlapping generations model developed by Pla-Porcel et al. (2016) to include two new features: a long-term care benefit graded according to the annuitant's degree of disability and a minimum pension benefit for both contingencies. This brings the model closer to the reality of social insurance and enhances its political attractiveness. The paper contains a numerical example to show how the model functions and focuses especially on the mortality rates for dependent persons, the inception ra…
Neurophysiological changes associated with implant-associated augmentation procedures in the lower jaw
2017
Background Neurophysiological changes after oral and maxillofacial surgery remain one of the topics of current research. Purpose This study evaluated if implant placement associated with augmentation procedures increases the possibility of sensory disturbances or result in impaired quality of life during the healing period. Material and Methods Patients who had obtained an implant placement in the lower jaw in combination with augmentation procedures were examined by implementing a comprehensive Quantitative Sensory Testing (QST) protocol for extra- and intraoral use. As augmentation procedures, we used Guided Bone Regeneration (Group A) and Customized Bone Regeneration (Group B) techniques…
Corrosion Resistance of Alloys in IGCC Environment
2001
IGCC recovery boiler materials are subject to severe corrosion in environments composed of a gas mixture (CO-H 2 -H 2 O-CO 2 -H 2 S) and vanadium-containing fly-ash resulting from the combustion of oil residues. This paper presents a study of the corrosion behaviour of two Fe-Ni-Cr austenitic alloys in a typical IGCC environment at 400°C. The alloy composition influences the vanadium incorporated in the corrosion scales during the test, which affects the scale growth process. The valence state (determined by micro-XANES) and the amount of the incorporated vanadium is modified by a subsequent air flow at 400°C.
Role of Hsp70 in Multiple Sclerosis: An Overview
2019
For many years heat shock protein 70 (Hsp70) was considered exclusively an intracellular chaperone contributing to protein proteostasis and in apoptotic pathway block. Lately it has been demonstrated that Hsp70 is actively released in the extracellular environment, thereby promoting the activation of the immune system by stimulating innate and adaptive responses through the activation of APCs. Its expression in the nervous system is induced in a variety of pathological conditions. Emerging evidences displayed that Hsp70 is a critical regulator in normal neural cells. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) directed against myelin antigens. In thi…