Search results for "Generation"

Hsp70 and Its Molecular Role in Nervous System Diseases

2011

Heat shock proteins (HSPs) are induced in response to many injuries including stroke, neurodegenerative disease, epilepsy, and trauma. The overexpression of one HSP in particular, Hsp70, serves a protective role in several different models of nervous system injury, but has also been linked to a deleterious role in some diseases. Hsp70 functions as a chaperone and protects neurons from protein aggregation and toxicity (Parkinson disease, Alzheimer disease, polyglutamine diseases, and amyotrophic lateral sclerosis), protects cells from apoptosis (Parkinson disease), is a stress marker (temporal lobe epilepsy), protects cells from inflammation (cerebral ischemic injury), has an adjuvant role i…

Driving impairment and crash risk in Parkinson disease: A systematic review and meta-analysis

2018

ObjectivesTo provide the best possible evidence base for guiding driving decisions in Parkinson disease (PD), we performed a meta-analysis comparing patients with PD to healthy controls (HCs) on naturalistic, on-the-road, and simulator driving outcomes.MethodsSeven major databases were systematically searched (to January 2018) for studies comparing patients with PD to HCs on overall driving performance, with data analyzed using random-effects meta-analysis.ResultsFifty studies comprising 5,410 participants (PD = 1,955, HC = 3,455) met eligibility criteria. Analysis found the odds of on-the-road test failure were 6.16 (95% confidence interval [CI] 3.79–10.03) times higher and the odds of sim…

p62: Friend or Foe? Evidences for OncoJanus and NeuroJanus Roles

2020

p62 is a versatile protein involved in the delicate balance between cell death and survival, which is fundamental for cell fate decision in the context of both cancer and neurodegenerative diseases. As an autophagy adaptor, p62 recognizes polyubiquitin chains and interacts with LC3, thereby targeting the selected cargo to the autophagosome with consequent autophagic degradation. Beside this function, p62 behaves as an interactive hub in multiple signalling including those mediated by Nrf2, NF-κB, caspase-8, and mTORC1. The protein is thus crucial for the control of oxidative stress, inflammation and cell survival, apoptosis, and metabolic reprogramming, respectively. As a multifunctional pr…

Lipofuscin Hypothesis of Alzheimer’s Disease

2011

The primary culprit responsible for Alzheimer’s disease (AD) remains unknown. Aβ protein has been identified as the main component of amyloid of senile plaques, the hallmark lesion of AD, but it is not definitively established whether the formation of extracellular Aβ deposits is the absolute harbinger of the series of pathological events that hit the brain in the course of sporadic AD. The aim of this paper is to draw attention to a relatively overlooked age-related product, lipofuscin, and advance the hypothesis that its release into the extracellular space following the death of neurons may substantially contribute to the formation of senile plaques. The presence of intraneuronal Aβ, sim…

Evaluación del valor diagnóstico y pronóstico de las alteraciones moleculares en la leucemia mieloide aguda de novo mediante el empleo de técnicas de…

2020

La leucemia mieloide aguda (LMA) es una enfermedad muy heterogénea desde el punto de vista biológico con numerosas alteraciones moleculares implicadas en su patogenia. El análisis simultáneo de estas alteraciones génicas es imprescindible para conocer los mecanismos de leucemogénesis y evaluar sus implicaciones clínicas de manera individualizada en cada paciente. Las técnicas de next generation sequencing (NGS) han demostrado ser una herramienta eficaz para el análisis integrado de la complejidad de las neoplasias mieloides, por ello, el objetivo de este estudio es realizar una validación técnica y clínica de un panel de NGS dirigida a genes o regiones recurrentemente mutados en la enfermed…

Continuous-Wave Backward Frequency Doubling in Periodically Poled Lithium Niobate

2010

Applicability of Interference Coordination in Highly Loaded HSUPA Network

2010

This paper evaluates the performance of highly loaded High Speed Uplink Packet Access (HSUPA) network with and without network wide static Interference Coordination (IC). IC alternates the priorities for user transmission periods throughout the network to achieve reduced interference levels and higher performance. A large variety of combinations including, e.g., different schedulers, cell center/edge user definitions (user splits) and interference targets are investigated in this paper. Performance is analyzed using a quasi-static system level simulator which is also used to support Third Generation Partnership Project (3GPP) standardization work. The simulator contains detailed and commonl…

The neuronal ceroid-lipofuscinoses: A historical introduction

2013

AbstractThe neuronal ceroid-lipofuscinoses (Batten disease) collectively constitute one of the most common groups of inherited childhood onset neurodegenerative disorders, and have also been identified in many domestic and laboratory animals. The group of human neuronal ceroid-lipofuscinoses currently comprises 14 genetically distinct disorders, mostly characterised by progressive mental, motor and visual deterioration with onset in childhood or adolescence. Abnormal autofluorescent, electron-dense granules accumulate in the cytoplasm of nerve cells, and this storage process is associated with selective destruction and loss of neurons in the brain and retina. The present paper outlines near…

Simulation analysis of fuel cell integration in a hybrid car

2019

Abstract Fuel cell is one of the green technologies that can help reduce toxic gas and decreasing effect of greenhouse gases in the world. This paper attempts to improve simulation model of fuel cell system that is easy to use and at the same time have an acceptable accuracy. The simulation model is developed through Matlab/Simulink software using Energetic Macroscopic Representation method which accuracy is compared with an established model. Simulation analysis of fuel cell integration is conducted by using experimental data from a real hybrid car. There are two potential types of system that were considered for the hybrid car in term of electricity generation and power produced to move t…

Implementation of a Management System for Prosumer Energy Storage Scheduling in Smart Grids

2020

Scheduling of energy storage systems of distributed generation is a key element for optimal renewable energy sources (RES) exploitation in smart grids, demand side response strategies implementation and prosumers interaction with Distribution System Operators (DSOs). In this context, this paper presents the implementation of a management system for energy storage scheduling, which allows taking appropriate account of the storage system behavior in real cases. To properly consider the real system operation, the employed battery model is modified, in order to include also the hysteresis phenomena in state of charge estimation in both charging and discharging operation. The validation of the p…