Search results for "Generation"

Transgenerationale Effekte belastender Kindheitserlebnisse auf die Borderline-Symptomatik von Jugendlichen

2014

Einleitung: Bisherige Forschungsergebnisse belegen substantielle Zusammenhänge zwischen dem Erleben von Missbrauchs- und Misshandlungserfahrungen in der Kindheit und der Entwicklung der Borderline Persönlichkeitsstörung im Erwachsenenalter. Die Frage nach transgenerationalen Effekten belastender Kindheitserlebnisse sowie möglicher intermittierender Variablen wird hingegen kontrovers diskutiert. Zudem beschäftigten sich bislang wenige Studien mit der Entwicklung von Borderline Symptomen im Jugendalter. An diesen Wissenslücken ansetzend, untersuchen wir die spezifischen Effekte belastender Kindheitserfahrungen von Eltern auf Borderline-Persönlichkeitsmerkmale der Folgegeneration sowie möglich…

Microglial involvement in neuroplastic changes following focal brain ischemia in rats.

2009

The pathogenesis of ischemic stroke is a complex sequence of events including inflammatory reaction, for which the microglia appears to be a major cellular contributor. However, whether post-ischemic activation of microglial cells has beneficial or detrimental effects remains to be elucidated, in particular on long term brain plasticity events. The objective of our study was to determine, through modulation of post-stroke inflammatory response, to what extent microglial cells are involved in some specific events of neuronal plasticity, neurite outgrowth and synaptogenesis. Since microglia is a source of neurotrophic factors, the identification of the brain-derived neurophic factor (BDNF) as…

Deficient Interhemispheric Connectivity Underlies Movement Irregularities in Parkinson’s Disease

2021

Background: Movement execution is impaired in patients with Parkinson’s disease. Evolving neurodegeneration leads to altered connectivity between distinct regions of the brain and altered activity at interconnected areas. How connectivity alterations influence complex movements like drawing spirals in Parkinson’s disease patients remains largely unexplored. Objective: We investigated whether deteriorations in interregional connectivity relate to impaired execution of drawing. Methods: Twenty-nine patients and 31 age-matched healthy control participants drew spirals with both hands on a digital graphics tablet, and the regularity of drawing execution was evaluated by sample entropy. We recor…

Towards controlling PCDD/F production in a multi-fuel fired BFB boiler using two sulfur addition strategies. Part II: Thermodynamic analysis

2014

Abstract A staged equilibrium process model was developed for a bubbling fluidized bed boiler firing SRF, bark and sludge. The model was used to study the influence of sulfur addition strategies (S-pellet additive and peat co-firing) on the behavior of copper, bromine, and alkalis. Aerosol samples collected from the backpass of the boiler were used to validate the chemistry predicted by the model. The model revealed that Cu existed as Cu 2 S (s3) in the reducing zone, and CuCl (g) (for all test cases) and CuO (s) (during peat co-firing) in the oxidation zones. CuBr 3(g) was also present after the introduction of tertiary air. However the model failed to predict the formation of CuSO 4 , an …

A Wnt-specific astacin proteinase controls head formation inHydra

2020

AbstractTheHydrahead organizer acts as a signaling center that initiates and maintains the primary body axis in steady state polyps and during budding or regeneration. Wnt/beta-Catenin signaling functions as a primary cue controlling this process, but how Wnt ligand activity is locally restricted at the protein level is poorly understood.Here we report the identification of an astacin family proteinase as a Wnt processing factor.Hydraastacin-7 (HAS-7) is expressed from gland cells as an apical-distal gradient in the body column, peaking close beneath the tentacle zone.HAS-7siRNA knockdown abrogates HyWnt3 proteolysis in the head tissue and induces a robust double axis phenotype, which is re…

Challenges in Energy Systems for the Smart-Cities of the Future

2012

In the last years the European Union has actively promoted the renewable energies and the Combined Heat and Power (CHP) also for residential and tertiary buildings. The exploitation of renewable sources and cogeneration seems hampered by the regulatory wall that prohibit for residential, tertiary and commercial buildings the constitution of users clusters. In fact, the unification up to a threshold value of some tens of kVA, at least, can facilitate the installation of renewable energy power plants as solar PV modules or CHP systems (cogeneration) or CCHP systems (tri-generation), overcoming technical and economical barriers and combining several load profiles. The actual distribution syste…

Designing a sustainable regeneration in the outskirt of Agrigento

2016

This paper describes a case of building recovery and sustainable re-use in Sicily, that is the recovery of Villaseta. It is a very degraded neighborhood in the outskirts of Agrigento. The main goal of the redevelopment project is therefore the rebuilding and the environmental regeneration of the neighborhood, using sustainable technologies and tools, with the construction of vegetable gardens and urban gardens, the production of renewable energy and the sustainable recovery of existing buildings. The eco-friendliness of the restoration project is therefore given by the use of garden roofs and vertical gardens. Villaseta will be a real "green lung" able to give greater environmental awarenes…

Global architecture: rehabilitation and regeneration

2022

Using architecture as a "global phenomenon", holistically integrating solutions inspired by new scientific progress in the field of urban ecology, is a proactive way of responding to the challenges and precariousness of the contemporary city. In this paper, which illustrates a process of building and urban regeneration developed within the framework of the agreement between the University of Palermo and CICOP "International Centre for the Conservation of Heritage" with the research entitled "G.A. Transition&Regeneration "*, it is necessary to evaluate all the opportunities and benefits that the inclusion of green spaces and lungs bring to building contexts in a perspective of eco-sustai…

Generational value shift in the Sinebrychoff family : A studyof late-empire Russian capitalists

2013

Explicit Bézier control net of a PDE surface

2017

The PDE under study here is a general fourth-order linear elliptic Partial Differential Equation. Having prescribed the boundary control points, we provide the explicit expression of the whole control net of the associated PDE Bézier surface. In other words, we obtain the explicit expressions of the interior control points as linear combinations of free boundary control points. The set of scalar coefficients of these combinations works like a mould for PDE surfaces. Thus, once this mould has been computed for a given degree, real-time manipulation of the resulting surfaces becomes possible by modifying the prescribed information. The work was partially supported by Spanish Ministry of Econo…