Search results for "Generation"

Dense drug-eluting biodegradable Fe-Ag nanocomposites

2021

Abstract Biodegradable metals in orthopedics are aimed to eliminate secondary the surgical intervention for implant removal, and thus improve patient compliance, reduce surgery costs and the risk of infections. In addition, biodegradable implants could be loaded with different drugs to prevent the growth of pathogens and the development of bone infections, kill remaining cancer cells after tumor resection or stimulate bone regeneration. However, drugs undergo thermal decomposition under the conditions of conventional metal fabrication processes. In this work, we describe the fabrication of a dense drug-eluting biodegradable Fe-Ag nanocomposite containing 10 vol% of Ag and loaded with the an…

MMP-10 Is Required for Efficient Muscle Regeneration in Mouse Models of Injury and Muscular Dystrophy

2013

Abstract Matrix metalloproteinases (MMPs), a family of endopeptidases that are involved in the degradation of extracellular matrix components, have been implicated in skeletal muscle regeneration. Among the MMPs, MMP-2 and MMP-9 are upregulated in Duchenne muscular dystrophy (DMD), a fatal X-linked muscle disorder. However, inhibition or overexpression of specific MMPs in a mouse model of DMD (mdx) has yielded mixed results regarding disease progression, depending on the MMP studied. Here, we have examined the role of MMP-10 in muscle regeneration during injury and muscular dystrophy. We found that skeletal muscle increases MMP-10 protein expression in response to damage (notexin) or diseas…

Dynamic contrast‐enhanced magnetic resonance imaging for monitoring angiogenesis during bone regeneration – a randomized pilot study in rabbits

2020

GAIML: A New Language for Verbal and Graphical Interaction in Chatbots

2008

Natural and intuitive interaction between users and complex systems is a crucial research topic in human-computer interaction. A major direction is the definition and implementation of systems with natural language understanding capabilities. The interaction in natural language is often performed by means of systems called chatbots. A chatbot is a conversational agent with a proper knowledge base able to interact with users. Chatbots appearance can be very sophisticated with 3D avatars and speech processing modules. However the interaction between the system and the user is only performed through textual areas for inputs and replies. An interaction able to add to natural language also graph…

A computational study of LP-based heuristic algorithms for two-dimensional guillotine cutting stock problems

2002

In this paper we develop and compare several heuristic methods for solving the general two-dimensional cutting stock problem. We follow the Gilmore-Gomory column generation scheme in which at each iteration a new cutting pattern is obtained as the solution of a subproblem on one stock sheet. For solving this subproblem, in addition to classical dynamic programming, we have developed three heuristic procedures of increasing complexity, based on GRASP and Tabu Search techniques, producing solutions differing in quality and in time requirements. In order to obtain integer solutions from the fractional solutions of the Gilmore-Gomory process, we compare three rounding procedures, rounding up, t…

In-Depth Analysis of Pricing Problem Relaxations for the Capacitated Arc-Routing Problem

2015

Recently, Bode and Irnich [Bode C, Irnich S (2012) Cut-first branch-and-price-second for the capacitated arc-routing problem. Oper. Res. 60(5):1167–1182] presented a cut-first branch-and-price-second algorithm for solving the capacitated arc-routing problem (CARP). The fundamental difference to other approaches for exactly solving the CARP is that the entire algorithm works directly on the typically sparse underlying graph representing the street network. This enables the use of highly efficient dynamic programming-based pricing algorithms to solve the column-generation subproblem also known as the pricing problem. The contribution of this paper is the in-depth analysis of the CARP pricing…

Effective Handling of Dynamic Time Windows and Its Application to Solving the Dial-a-Ride Problem

2015

A dynamic time window relates to two operations that must be executed within a given time meaning that the difference between the points in time when the two operations are performed is bounded from above. The most prevalent context of dynamic time windows is when precedence is given for the two operations so that it is a priori specified that one operation must take place before the other. A prominent vehicle routing problem with dynamic time windows and precedence is the dial-a-ride problem (DARP), where user-specified transportation requests from origin to destination points must be serviced. The paper presents a new branch-and-cut-and-price solution approach for the DARP, the prototypi…

Gluon mass generation in the presence of dynamical quarks

2013

We study in detail the impact of dynamical quarks on the gluon mass generation mechanism, in the Landau gauge, for the case of a small number of quark families. As in earlier considerations, we assume that the main bulk of the unquenching corrections to the gluon propagator originates from the fully dressed quark-loop diagram. The nonperturbative evaluation of this diagram provides the key relation that expresses the unquenched gluon propagator as a deviation from its quenched counterpart. This relation is subsequently coupled to the integral equation that controls the momentum evolution of the effective gluon mass, which contains a single adjustable parameter; this constitutes a major impr…

Frequency and Characterization of Movement Disorders in Anti-IgLON5 Disease

2021

Background and ObjectivesAnti-IgLON5 disease is a recently described neurologic disease that shares features of autoimmunity and neurodegeneration. Abnormal movements appear to be frequent and important but have not been characterized and are underreported. We describe the frequency and types of movement disorders in a series of consecutive patients with this disease.MethodsIn this retrospective, observational study, the presence and phenomenology of movement disorders were assessed with a standardized clinical questionnaire. Available videos were centrally reviewed by 3 experts in movement disorders.ResultsSeventy-two patients were included. In 41 (57%), the main reason for initial consult…

Eppur si muove. Partecipare per contribuire alle decisioni nei contesti urbani fragili

2021

Il progetto, concluso in periodo di COVID19, ha attivato percorsi di tipo partecipativo sul modello del dibattito pubblico sia in presenza che mediante utilizzo delle tecnologie di comunicazione e informazione (ICT) via web. Sia il Comune di Palermo che la Valletta hanno realizzato percorsi partecipativi culminati in eventi che hanno raccolto le considerazioni finali utili alla costruzione di linee guida per le politiche pubbliche orientate all’accessibilità del patrimonio per tutti. Il contributo muove dalla analisi dei metodi dell’applicazione delle tecnologie ICT agli approcci partecipativi per le decisioni in ambito pubblico. Tali strumenti non risolvono il conflitto sociale ma a volte …