Search results for "Genetic algorithm"

Algorithms and tools for protein-protein interaction networks clustering, with a special focus on population-based stochastic methods

2014

Abstract Motivation: Protein–protein interaction (PPI) networks are powerful models to represent the pairwise protein interactions of the organisms. Clustering PPI networks can be useful for isolating groups of interacting proteins that participate in the same biological processes or that perform together specific biological functions. Evolutionary orthologies can be inferred this way, as well as functions and properties of yet uncharacterized proteins. Results: We present an overview of the main state-of-the-art clustering methods that have been applied to PPI networks over the past decade. We distinguish five specific categories of approaches, describe and compare their main features and …

Comments on “Unobservable Selection and Coefficient Stability

2019

Abstract–: We establish a link between the approaches proposed by Oster (2019) and Pei, Pischke, and Schwandt (2019) which contribute to the development of inferential procedures for causal effects in the challenging and empirically relevant situation where the unknown data-generation process is not included in the set of models considered by the investigator. We use the general misspecification framework recently proposed by De Luca, Magnus, and Peracchi (2018) to analyze and understand the implications of the restrictions imposed by the two approaches.

A heuristic method for estimating attribute importance by measuring choice time in a ranking task

2012

The evaluation of a product or service in terms of its attributes has been broadly studied in marketing, management and decision sciences. However, methods for finding important attributes have theoretical and practical limitations. The former are related to the selection of the most appropriate model; the latter are due to large number of variables that affect the specific experimental context. This study aims to present a new methodology that captures attribute preferences from a respondent and in particular, by using the choice time in a ranking task, it allows to indirectly obtain the importance weights for several tested attributes through a simple, fast and inexpensive procedure. More…

Multiple smoothing parameters selection in additive regression quantiles

2021

We propose an iterative algorithm to select the smoothing parameters in additive quantile regression, wherein the functional forms of the covariate effects are unspecified and expressed via B-spline bases with difference penalties on the spline coefficients. The proposed algorithm relies on viewing the penalized coefficients as random effects from the symmetric Laplace distribution, and it turns out to be very efficient and particularly attractive with multiple smooth terms. Through simulations we compare our proposal with some alternative approaches, including the traditional ones based on minimization of the Schwarz Information Criterion. A real-data analysis is presented to illustrate t…

Criteria for Bayesian model choice with application to variable selection

2012

In objective Bayesian model selection, no single criterion has emerged as dominant in defining objective prior distributions. Indeed, many criteria have been separately proposed and utilized to propose differing prior choices. We first formalize the most general and compelling of the various criteria that have been suggested, together with a new criterion. We then illustrate the potential of these criteria in determining objective model selection priors by considering their application to the problem of variable selection in normal linear models. This results in a new model selection objective prior with a number of compelling properties.

Algorithm AS 105: Fitting a Covariance Selection Model to a Matrix

1977

Model selection in linear mixed-effect models

2019

Linear mixed-effects models are a class of models widely used for analyzing different types of data: longitudinal, clustered and panel data. Many fields, in which a statistical methodology is required, involve the employment of linear mixed models, such as biology, chemistry, medicine, finance and so forth. One of the most important processes, in a statistical analysis, is given by model selection. Hence, since there are a large number of linear mixed model selection procedures available in the literature, a pressing issue is how to identify the best approach to adopt in a specific case. We outline mainly all approaches focusing on the part of the model subject to selection (fixed and/or ra…

On stability issues in deriving multivariable regression models

2014

In many areas of science where empirical data are analyzed, a task is often to identify important variables with influence on an outcome. Most often this is done by using a variable selection strategy in the context of a multivariable regression model. Using a study on ozone effects in children (n = 496, 24 covariates), we will discuss aspects relevant for deriving a suitable model. With an emphasis on model stability, we will explore and illustrate differences between predictive models and explanatory models, the key role of stopping criteria, and the value of bootstrap resampling (with and without replacement). Bootstrap resampling will be used to assess variable selection stability, to d…

Eleccion de variables en regresion lineal un problema de decision

1986

A general structure for the problem of selection of variables in regression is proposed using the decision theory framework. In particular, some results for the choice of the best linear normal homocedastic model are obtained when the main purpose is either to specify the predictive distribution over the response variable or to obtain a point estimate of it. A comparison of our results with the most widespread classical ones is presented

Diseño muestral optimo en el caso de no respuesta

1982

Discussed here are several aspects of a simple model for dealing with nonresponse. The model is, in a sense, a sequential one and is developed from a Bayesian decision theory point of view. Within this framework we examine how formalization and combination of one's opinions, and past experience concerning the proportion of nonrespondents, the differences and relations between respondents and nonrespondents, the cost of obtaining information from nonrespondents, etc. We examine the decisions concerning the selection of sampling size m and n, both in the nonrespondent population and in the overall population