Search results for "Genetica"
showing 10 items of 906 documents
THAP11 and HP1BP3 proteins are component of the HB-2.8 enhancer-blocker located in the human c-MYC chromatin domain.
2011
Estudio de intervención en pérdida de peso y cambios en los valores de parámetros metabólicos, antropométricos y modulación de fenotipos intermedios …
2023
El Síndrome metabólico junto a la obesidad son las grandes pandemias del siglo XXI estimando su prevalencia global superior al 30%. El Síndrome metabólico comienza con la obesidad central, siendo ésta la que promueve la aparición de otras alteraciones y factores de riesgo (la resistencia a la insulina, la hipertensión y la dislipidemia). La prevención de la obesidad y del Síndrome metabólico permitirá reducir la incidencia actual de enfermedades crónicas, incluidas la diabetes, las enfermedades cardiovasculares y distintos tipos de cáncer, que, a su vez, son causas cada vez más importantes de discapacidad y muerte prematura. En el desarrollo del Síndrome metabólico intervienen diversos fact…
Flavonoid metabolism and gene expression in developing olive (Olea europaea L.) fruit.
2012
The expression pattern of six genes (phenylalanine-ammonia-lyase, PAL, chalcone synthase, CHS, flavanone 3-hydroxylase, F3H, dihydroflavonol 4-reductase, DFR, anthocyanidin synthase, ANS, UDP-gluco...
Metabolomics approach to studying minimally processed peach (Prunus persica) fruit
2012
Fresh-cut fruit products for both retail and food service applications have increasingly appeared in the market place in recent years. Among different fruit types, peaches can be used and are highly appreciated as fresh-cut product although their commercial success is limited due to their short shelf-life and the quick onset of wounding-related physiological reactions. In this work we analyzed the technological and physiological changes induced by fresh-cut preparation in three different types of peach cultivars: 'Fayette' (melting), 'Wilhelmina' (non-melting) and 'Ghiaccio3' (stony hard). We performed a metabolite targeting profiling to focus on the changes in organic acid levels, importan…
Epigenetic involvement in Hutchinson-Gilford progeria syndrome: a mini-review.
2013
Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to a severe premature ageing phenotype, caused by mutations in the <i>LMNA</i> gene. The <i>LMNA</i> gene codes for lamin-A and lamin-C proteins, which are structural components of the nuclear lamina. HGPS is usually caused by a de novo <i>C1824T</i> mutation that leads to the accumulation of a dominant negative form of lamin-A called progerin. Progerin also accumulates physiologically in normal ageing cells as a rare splicing form of lamin-A transcripts. From this perspective, HGPS cells seem to be good candidates for the study of the physiological mechanisms of ageing…
A ceRNA analysis on LMNA gene focusing on the Hutchinson-Gilford progeria syndrome
2013
Background: Hutchinson-Gilford progeria syndrome is a rare dominant human disease of genetic origin. The average life expectancy is about 20 years, patients’ life quality is still very poor and no efficient therapy has yet been developed. It is caused by mutation of the LMNA gene, which results in accumulation in the nuclear membrane of a particular splicing form of Lamin-A called progerin. The mechanism by which progerin perturbs cellular homeostasis and leads to the symptoms is still under debate. Micro-RNAs are able to negatively regulate transcription by coupling with the 3’ UnTranslated Region of messenger RNAs. Several Micro-RNAs recognize the same 3’ UnTranslated Region and each Micr…
Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons
2020
Cystic fibrosis (CF) is caused by mutations in the gene encoding the transmembrane conductance regulator (CFTR) protein. Some CF patients are compound heterozygous or homozygous for nonsense mutations in the CFTR gene. This implies the presence in the transcript of premature termination codons (PTCs) responsible for a truncated CFTR protein and a more severe form of the disease. Aminoglycoside and PTC124 derivatives have been used for the read-through of PTCs to restore the full-length CFTR protein. However, in a precision medicine framework, the CRISPR/dCas13b-based molecular tool &ldquo
Riarrangiamenti cromosomici: i nuovi centromeri evolutivi nei primati. (Chromosomal rearrangements: evolutionary new centromeres in primates).
2012
Light induces expression of a dehydrin-encoding gene during seedling de-etiolation in sunflower (Helianthus annus L.)
2007
The effects of light quality on the expression of a sunflower dehydrin-encoding gene, HaDhn1, were studied during seedling de-etiolation. Seeds were germinated in the dark and, after 5 days, seedlings were maintained well watered and de-etiolated under different lights for 3, 6, 12, and 24h. Exposure to white light stimulated HaDhn1 transcript accumulation in the cotyledons of these seedlings, contrary to seedlings grown in the dark. HaDhn1 transcripts increased also treating plantlets with monochromatic lights, especially red light. The increase of HaDhn1 transcripts is provoked by the formation of the active form of phytochrome. Further experiments, performed saturating active phytochrome…
El futuro del derecho como lucha contra la idolatría tecnológica
2019
The main challenge that Law will have to face in the near future is the defense of human being against the uncontrolled power of technology in different spheres: ecology versus the becoming of a new geological age: the Anthropocene; the finances, versus speculation and taxes fraud; biolaw, versus the transhumanist challenge; the rights to privacy and no manipulation versus GAF( Google, Amazon, Facebook). El reto principal al que debera hacer frente el derecho en el futuro es la defensa del ser humano frente al poder incontrolado de la tecnologia en diferentes campos: la ecologia, frente a la aparicion de una nueva era geologica: el Antropoceno; las finanzas, frente a la especulacion y el fr…