Search results for "Genou"

Melatonin and phytomelatonin: Chemistry, biosynthesis, metabolism, distribution and bioactivity in plants and animals—an overview

2021

Melatonin is a ubiquitous indolamine, largely investigated for its key role in the regulation of several physiological processes in both animals and plants. In the last century, it was reported that this molecule may be produced in high concentrations by several species belonging to the plant kingdom and stored in specialized tissues. In this review, the main information related to the chemistry of melatonin and its metabolism has been summarized. Furthermore, the biosynthetic pathway characteristics of animal and plant cells have been compared, and the main differences between the two systems highlighted. Additionally, in order to investigate the distribution of this indolamine in the plan…

STAT5 is crucial to maintain leukemic stem cells in acute myelogenous leukemias induced by MOZ-TIF2.

2012

Abstract MOZ-TIF2 is a leukemogenic fusion oncoprotein that confers self-renewal capability to hematopoietic progenitor cells and induces acute myelogenous leukemia (AML) with long latency in bone marrow transplantation assays. Here, we report that FLT3-ITD transforms hematopoietic cells in cooperation with MOZ-TIF2 in vitro and in vivo. Coexpression of FLT3-ITD confers growth factor independent survival/proliferation, shortens disease latency, and results in an increase in the number of leukemic stem cells (LSC). We show that STAT5, a major effector of aberrant FLT3-ITD signal transduction, is both necessary and sufficient for this cooperative effect. In addition, STAT5 signaling is essent…

Fatal sepsis due to mycobacterium tuberculosis after allogeneic bone marrow transplantation.

2001

Mycobacterium tuberculosis is a serious, but rare infectious complication after allogeneic bone marrow transplantation. We describe a case of fatal sepsis due to Mycobacterium tuberculosis after allogeneic bone marrow transplantation for Philadelphia chromosome-positive ALL. The diagnosis was made after BAL. Although broad-spectrum antituberculous therapy was started immediately after diagnosis, blood cultures became positive for Mycobacterium tuberculosis. The patient developed severe pyrexias and finally died of multi-organ failure. Rapid progression of mycobacterial infection should be considered in patients post BMT with unexplained fever, particularly in patients from endemic areas.

Coelobiontic communities in neptunian fissures of synsedimentary tectonic origin in Permian reef, southern Urals, Russia

2007

Sedimentary dykes in the Permian reef complexes of the Russian platform are well preserved and important in providing information about reef growth, the reef biota and, particularly, cavity-dwelling organisms and sediment sources. Two main fissure assemblages are recognized with N80° and N170° (late Asselian-early Sakmarian) and N130°–140° and N60° (Sakmarian-Artinskian) orientations. These contemporaneous orthogonal dyke sets present orientations corresponding to the regional tectonic fabric and a tectonic origin for fracturing associated with the foreland basin development. The largest dykes record eight lithofacies and several stages of fracture opening. Stromatoids and centimetre-thick …

Outlines of the Quaternary geology of Latvia

2014

Insulin resistance and endogenous digoxin-like factor in obese hypertensive patients with glucose intolerance

1992

Hypertensive obese subjects with glucose intolerance have hyperinsulinaemia, insulin resistance and intracellular cation imbalance resulting in increased sodium content. The aim of our study was to assess in these patients plasma levels of endogenous digoxin-like factor (EDLF), an inhibitor of the sodium-pump mechanism. We studied 14 hypertensive and 12 normotensive subjects with obesity and glucose intolerance for fasting blood glucose, and plasma insulin, C-peptide and EDLF levels: the two groups were matched for age and BMI and were studied after a 2-week wash-out period from hypotensive drugs. Compared with normotensives, hypertensive subjects had higher plasma insulin levels, a greater…

Testimonios indígenas conosureños: ¿convivencias excluyentes?

2016

Resumen: El presente articulo, partiendo de lapremisa de que la teoria del testimonio en AmericaLatina fue construida a partir de textos testimonialesdel area centroamericana y caribena sobre la base deun trasfondo marxista, revisa de manera panoramicatestimonios de cuatro culturas indigenas deSudamerica (quechua, aymara, mapuche y yagan)resaltando la dimension cultural contenida en estos.Se caracterizan tanto las condiciones de produccionde estos testimonios como tambien las formas deconvivencia que estos representan. Las exclusionesque padecen los testimoniantes por parte de susrespectivas sociedades se interpretan comoconsecuencia de la idea ilustrada de progreso que guiola construccion …

Reliability and validity of the Newcastle Scales in relation to ICD-9-classification

1987

The assessment of endogenous depression by means of the Newcastle Scales (1965, 1971) has been validated by their correlation with biological findings in many previous studies. However, reliability and cross validation studies are lacking for these scales. We found the reliability of the Newcastle Scales to be sufficient or at least moderate in a sample of 70 inpatients with major depression. In order to cross validate both scales, the clinical classification according to ICD-9 and the assessment of the Newcastle Scales have been performed independently in a sample of 112 inpatients with Major Depressive Disorder (RDC). The rate of agreement between clinical diagnosis and classification acc…

« Deirdre O’Mahony, artiste et archéologue des savoirs techniques indigènes »

2022

Les projets participatifs et collaboratifs de l’artiste irlandaise Deirdre O’Mahony, ancrés dans le monde rural du Burren, valorisent le patrimoine vernaculaire et les savoir-faire indigènes. Ses recherches de terrain portant sur l’évolution du paysage abordé comme milieu et les collaborations multiples qu’elle entreprend aboutissent à des propositions artistiques revisitant le land art. Ses interventions dans le paysage sont souvent complétées par des propositions dialogiques, dont le repas partagé, qui invite les participants à explorer l’histoire des lieux, les jeux de pouvoir qui s’y tissent et la pertinence des savoirs vernaculaires pour les enjeux de demain, notamment en matière de sé…

Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo chronic myelogenous Leukemia cell growth

2017

Despite Imatinib (IM), a selective inhibitor of Bcr-Abl, having led to improved prognosis in Chronic Myeloid Leukemia (CML) patients, acquired resistance and long-term adverse effects is still being encountered. There is, therefore, urgent need to develop alternative strategies to overcome drug resistance. According to the molecules expressed on their surface, exosomes can target specific cells. Exosomes can also be loaded with a variety of molecules, thereby acting as a vehicle for the delivery of therapeutic agents. In this study, we engineered HEK293T cells to express the exosomal protein Lamp2b, fused to a fragment of Interleukin 3 (IL3). The IL3 receptor (IL3-R) is overexpressed in CML…