Search results for "Germ Cell"
showing 10 items of 111 documents
MALIGNANT GERM CELL TUMOURS in CHILDHOOD: the Italian Experience
1998
Malignant Germ Cell Tumours (MGCT) account approximately 3% of all malignancies in the paediatric age group. Although many of them are curable, their natural history, staging, systems and optimal treatment still need to be better defined. Tha data of an Italian co-operative study are reported here
THE ROLE OF SURGERY (s) IN THE TREATMENT OF GERM CELL TUMORS (GCT) IN CHILDHOOD. A Report from an Italian Multi-Istitutional Study (TCG-91)
1993
GCT account for about 3% of all solidi Neoplasms in children. Because of the confusion as to their classification, diagnostic apporoach and treatment, a multi-istitutional study was carried and a National Protocol for Diagnosis and treatment of CGT (TCG-91), approved by AIEOP, straded in January 1991.
STAGE I GONADAL CELL TUMORS (GGCT): OUTCOME AFETR THE SURVEILLANCE STRATEGY AS APPLIED IN THE ASSOCIAZIONE ITALIANA EMATOLOGIA ONCOLOGIA PEDIATRICA (…
2012
Suveillance strategy is a standerd option in stage 1° testicular GCT and suggested for ovarian GCT too. Worries regarding the relapse risk in ovarian are emerging. We here report on our series of stage 1° GGCT
MALIGNANT NON-SEMINOMATOUS GERM CELL TUMORS (MNSGCT) IN CHILDREN: Results of a Study of Italian Association Pediatric Oncology (AIEOP).
1995
The authors report the results of the Italian study on the treatment of non-seminomatous germ cell tumors in pediatric age and present the results of the diagnostic and therapeutic process in their experience
GERM CELL TUMOURS IN CHILDREN- A Report of 84 Cases
1994
In January 1991 a Protocol for diagnosis and treatment of Germ Cell Tumours (GCT) in children was activated in 15 Italian Paediatric Centres.
IL RUOLO DELLA CHIRURGIA NEL TRATTAMENTO DEI TUMORI GERMINALI IN ETA' PEDIATRICA: Analisi dello Studio Cooperativo "AIEOP TCG-'91.
1993
Authors analyze the preliminary results of the first multicentric cooperative study on Germ Celkl Tumors in childhood (TCG 91). The Authors discuss the role of primary surgical procedure on the treatment of benign forms and of resectable malignant tumors.
PEDIATRIC TESTICULAR GERM CELL TUMORS: the ASSOCIAZIONE ITALIANA ONCOLOGIA PEDIATRICA (AIEOP) study
2017
We describe the results of a therapeutic approach with a pediatric BEP regimen (bleomycin, etoposide, cisplatin) from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) study on testicular germ cell tumors (TGCT).
Sperm imprinting integrity in seminoma patients?
2018
IF 4.990; International audience; BackgroundTesticular germ cell tumor such as seminoma is strongly associated with male reproductive problems commonly associated with the alteration of sperm parameters as described in testicular dysgenesis syndrome. Interestingly, numerous studies have reported that the precursor of germ cell cancer, germ cell neoplasia in situ (GCNIS), present similarities to fetal gonocytes, specifically characterized by global DNA hypomethylation particularly on imprinting sequences. These disorders may have a common origin derived from perturbations of embryonal programming during fetal development. Presently, there is no available information concerning the sperm DNA …
Characterization and DNA-binding properties of GRF, a novel monomeric binding orphan receptor related to GCNF and betaFTZ-F1
1999
0014-2956 (Print) Comparative Study Journal Article Research Support, Non-U.S. Gov't; A PCR approach has been used to isolate, from Bombyx mori, a cDNA encoding a novel orphan receptor (GRF) that is most closely related to Bombyx betaFTZ-F1 and to the vertebrate germ cell nuclear factor. The major GRF mRNA is detected in most tissues as an 8-kb transcript whose amount follows the circulating ecdysteroid concentration with a delay. The expression pattern of GRF is similar to that of the Bombyx homologue of the Drosophila early-late gene DHR3, and precedes that of betaFTZ-F1 in all stages and tissues examined. The GRF protein is thus likely to be required in many tissues, but in a temporally …
Nuclear Medicine Methods in Scrotal Imaging
2011
In patients with acute scrotal pain scrotal scintigraphy can be used to exclude torsion of the testicle, which presents with unilateral decrease in activity on the affected side.The role of nuclear medicine methods, however, faded in the last years after the introduction of high performance color Doppler ultrasound equipment. Lymphoscintigraphy can be used in patients with testicular cancer to demonstrate the lymphatic drainage pathway of the neoplasm. Several studies suggest that 18FDG-PET/CT might have a role in the staging germ cell tumors, in identification of recurrent/residual disease, to monitor the treatment response and during the follow-up. Other investigations, however, did not c…