Search results for "GiST"

Adjuvant Imatinib in Patients with GIST Harboring Exon 9 KIT Mutations : Results from a Multi-institutional European Retrospective Study

2022

[Purpose] The effect of high-dose imatinib (800 mg/day) on survival in the adjuvant treatment of patients with resected KIT exon 9–mutated gastrointestinal stromal tumors (GIST) is not established. Here, the association of dose and other clinicopathologic variables with survival was evaluated in a large multi-institutional European cohort.

The Safety Culture Enactment Questionnaire (SCEQ): Theoretical model and empirical validation

2015

This paper presents the Safety Culture Enactment Questionnaire (SCEQ), designed to assess the degree to which safety is an enacted value in the day-to-day running of nuclear power plants (NPPs). The SCEQ is based on a theoretical safety culture model that is manifested in three fundamental components of the functioning and operation of any organization: strategic decisions, human resources practices, and daily activities and behaviors. The extent to which the importance of safety is enacted in each of these three components provides information about the pervasiveness of the safety culture in the NPP. To validate the SCEQ and the model on which it is based, two separate studies were carried…

Studime albanologjike: filologjike-letrare dhe historiko-kulturore

2018

Il volume riunisce saggi dedicati a vari momenti e temi dell'albanistica (filologia, linguistica, dialettologia, storia della cultura, letteratura)

A.Quondam, Forma del vivere.L'etica del gentiluomo e i moralisti italiani.

2011

Sakšu Morica darbība Kurzemē: studiju darbs

1943

Sakārtojuma saikļi dažādu reģistru tekstu saliktos sakārtotos teikumos

2017

Šajā pētījumā tiek analizēti sakārtojuma saikļi saliktos sakārtotos teikumos Britu Nacionālajā Korpusā. Pētījuma mērķis ir izpētīt sakārtojuma saikļu, kas saista neatkarīgas teikuma daļas saliktos sakārtotos teikumos tekstos, kas sagrupēti četros dažādos reģistros (akadēmiski teksti, daiļliteratūra, laikraksti un sarunas) Britu Nacionālajā Korpusā, biežumu un dažādību. Teorētiskā pētījuma metode, kas tika izmantota, ir teoriju par sakārtojuma saikļiem, saliktiem sakārtotiem teikumiem, reģistru un korpusu salīdzināšana. Sekojošas kvantitatīvās pētījuma metodes tika izmantotas – pirmkārt, saliktu sakārtotu teikumu ieguve no korpusa, pēc tam tika izmantotas tādas aprakstošās statistikas metode…

The role of information and communication technologies and logistics organization in the economic performance of Sicilian fruit and vegetable enterpr…

2013

Through a direct survey conducted on a sample of firms operating in the Sicilian fruit and vegetable sector, the present study provides an empirical evidence on the degree of diffusion of ICTs as well as on relationships with the regional distribution system. To pursue this goal, a multiple regression analysis model was implemented to identify which factors affect more the economic results of fruit and vegetable enterprises. The main results of the analysis indicate that firms using specific software for accounting, warehousing, payment and sales orders and contracts, are more likely to obtain higher economic performances under the “coeteris paribus” condition, as well as firms which are eq…

Ítems contextualizados de PISA Ciencias: La conexión entre las demandas cognitivas y las características de contexto de los ítems

2016

El uso frecuente de contextos en los ítems de la prueba se basa en la premisa de que la contextualización de ítems es una estrategia eficaz para comprobar si los estudiantes pueden aplicar o transferir sus conocimientos. En este trabajo, seguimos una línea de investigación que se centra en probar esta premisa. Se presenta un estudio de las características del contexto en una muestra de ítems de PISA ciencias de 2006 y 2009 y cómo estas características, así como el rendimiento del estudiante puede estar relacionado con las demandas cognitivas en los ítems. El estudio se basa en dos preguntas de investigación: (1) ¿Cuáles son las demandas cognitivas de los ítems contextualizados en la muestra…

Penalized logistic regression for small or sparse data: interval estimators revisited

2015

This paper focuses on interval estimation in logistic regression models fitted through the Firth penalized log-likelihood. In this context, many authors have claimed superiority of the Likelihood ratio statistic with respect to the (wrong) Wald statistic via simulation evidence. We re-assess such findings by detailing the inferential tools also including in the comparisons the (right) Wald statistic and other statistics neglected in previous literature. In particular, we assess performances of the CIs estimators by simulation and compare them in a real data set. Differently from previous findings, the Likelihood ratio statistic does not appear to be the best inferential device in Firth pena…

Abstract LB-295: Detection of oncogenic kinase mutations in circulating plasma DNA and correlation with clinical benefit in the phase III GRID study …

2013

Abstract Background: GRID is a phase III study for patients with advanced gastrointestinal stromal tumors (GIST) following failure of imatinib (I) and sunitinib (S) who were randomized to receive either the multikinase inhibitor regorafenib (R) or placebo (P). R demonstrated a highly significant improvement in progression-free survival compared with P (HR 0.27, p<0.0001). A preplanned retrospective biomarker analysis was conducted to assess GIST genotypes in GRID patients and to explore the possible impact of different driver oncogene mutations on clinical outcomes. Methods: DNA was isolated from archival tumor tissue and analyzed for KIT mutations via Sanger sequencing. The expectat…