Search results for "Goti"
showing 10 items of 634 documents
Genetic and Environmental Effects on Telomere Length and Lung Function: A Twin Study.
2015
Background The purpose of the study was to estimate the heritability of leukocyte telomere length (LTL) and lung function and to examine whether LTL and lung function share genetic or environmental effects in common. Methods 386 monozygotic and dizygotic Finnish twin sisters (age 68.4±3.4 years) were included. Relative LTL was determined from peripheral blood DNA by qPCR. Lung function measures of FEV1, FVC, FEV1/FVC, and PEF were derived from spirometry. Genetic modeling was performed with MPlus statistical software. Results Univariate analysis revealed that in LTL, 62% (95% confidence interval 50-72) of the variance was explained by additive genetic and 38% (28-50) by unique environmental…
Anisometropia of ocular refractive and biometric measures among 66- to 79-year-old female twins
2016
Purpose To examine the prevalence of anisometropia of spherical refraction (AnisoSR), astigmatism (AnisoAST) and spherical equivalent (AnisoSE) and their associations with spherical refraction (SR), refractive astigmatism (AST), spherical equivalent (SE) and interocular differences of ocular biometric parameters among elderly female twins. Methods Refraction of 117 monozygotic (MZ) and 116 dizygotic (DZ) female twin subjects aged 66–79 years was assessed with an auto-refractor (Topcon AT) and controlled by subjective refraction. Corneal refraction, anterior chamber depth and axial length were measured with a Zeiss IOL Master. Participants with eyes operated for cataract or glaucoma were exc…
Leukocyte and Skeletal Muscle Telomere Length and Body Composition in Monozygotic Twin Pairs Discordant for Long-term Hormone Replacement Therapy
2017
Estrogen-based hormone replacement therapy (HRT) may be associated with deceleration of cellular aging. We investigated whether long-term HRT has effects on leukocyte (LTL) or mean and minimum skeletal muscle telomere length (SMTL) in a design that controls for genotype and childhood environment. Associations between telomeres, body composition, and physical performance were also examined. Eleven monozygotic twin pairs (age 57.6 ± 1.8 years) discordant for HRT were studied. Mean duration of HRT use was 7.3 ± 3.7 years in the user sister, while their co-twins had never used HRT. LTL was measured by qPCR and SMTLs by southern blot. Body and muscle composition were estimated by bioimpedance an…
Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement
2018
Tissue-specific effects of 17 beta-estradiol are delivered via both estrogen receptors and microRNAs (miRs). Menopause is known to affect the whole-body fat distribution in women. This investigation aimed at identifying menopause-and hormone replacement therapy (HRT)-associated miR profiles and miR targets in subcutaneous abdominal adipose tissue and serum from the same women. A discovery phase using array technology was performed in 13 women, including monozygotic twin pairs discordant for HRT and premenopausal young controls. Seven miRs, expressed in both adipose tissue and serum, were selected for validation phase in 34 women from a different cohort. An age/menopause-related increase of …
Getting into the Same Boat – Enabling the Realization of the Disabled Child’s Agency in Adult–Child Play Interaction
2021
The purpose of this study was to find out how an adult can enable or hinder the realization of a disabled child’s agency in play interaction. We focused on the child’s play invitations, which were constructed as dispreferred by the adult. The data consisted of nine videotaped playing situations with five nurses and five disabled children in a children’s neurological ward. The microanalysis with interventionist applied conversation analysis focused on one playing situation between one nurse and one three-year-old boy with no spoken language. The nurse responded to the child’s play invitations constructed as dispreferred by her in three different ways. Two of them were about trying to control…
Assessment of learning strategies with the ACRA and the Brief-ACRA scales: Competitive models, measurement invariance, and prediction of academic ach…
2021
Abstract Learning strategies have been widely studied, and they have been related to academic achievement in several studies. Among the measurement instruments developed, the 44-item version of the Learning Strategies Scale (ACRA) is, by far, one of the most widely used questionnaires in the Spanish speaking context. This instrument has been recently shortened to a 17-item version. Neither the 44-item nor the 17-item version have been tested in the Dominican Republic. The aim of this study is to study the psychometric properties of the 44-item and 17-item versions of the ACRA. Participants were 1712 Dominican secondary school students. Both structures of the ACRA were tested via CFA; alpha …
Interventions of speakers of Polish and British parliaments in the light of politeness theory
2021
Abstract The present study attempts to analyze the interventions of Speakers of Polish and British Parliaments in the selected exchanges from 2018 to 2019 in terms of discourse-sensitive politeness theory advanced by Jonathan Culpeper. He proposes to use three types of impoliteness that affect three types of interlocutors’ faces via a range of impoliteness strategies. In the analyses we consider the linguistic, personal, and cultural as well as political context of the exchanges against the background of the unique, historically rooted institutional circumstances, with a special emphasis on the role of different physical contexts of respective Parliamentary chambers. We emphasize the discur…
Using discourse markers to negotiate epistemic stance: A view from situated language use
2021
Abstract In this paper, I analyse the usage of a discourse marker =mari, belonging to the epistemic paradigm attested in Upper Napo Kichwa (Quechuan, Ecuador). I show that the use of =mari indicates that the information is known well to the speaker, but also to some extent familiar to the addressee. In situated language use, the marker contributes to creating a knowing epistemic stance of the speaker. The analysis presented here is based on a 13-h documentary corpus of interactive Upper Napo Kichwa discourse, recorded on audio and video. For the purpose of the paper, the relevant utterances are analysed in their broad interactional context, including not only the surrounding text, but also …
"So you're saying": the interrogation of Jordan Peterson
2021
<p class="p1">In this article, I analyse the infamous Cathy Newman interview with Jordan Peterson on the 16th of January 2018 and subsequent viewer comments on Channel 4's YouTube channel. My first hypothesis is that Newman's frequent attribution of statements to Peterson using the now notorious "so you are saying" gambit (YSG) is what triggered outrage among Peterson's followers, which, in turn, generated media interest. My second hypothesis is that the interview is best understood as a series of Face threats by Newman on Peterson using the YSG. To ascertain if my hypotheses are true, I performed corpus linguistic analyses on the interview and comments to provide objective descriptio…
Odysseus the traveler: Appropriation of a chronotope in a community of practice
2020
Abstract In this article we analyze the role of chronotopes in the formation and negotiation of identities. In particular, we consider the case of a superdiverse community of practice formed by minors asylum seekers and teachers in a school of Italian in Sicily, Italy. In our analysis we stress the role of reciprocity on the ways in which the chronotopic figure of Odysseus is reinterpreted and appropriated by members of this community. We look at how through a process of mutual engagement the indexical values associated with the figure of Odysseus are recontextualized by both teachers and students in light of their present experiences. Data for the article come from interviews, narratives a…