Search results for "Gradient"
showing 10 items of 725 documents
3H-cyproterone acetate: binding characteristics to human uterine progestagen receptors
1985
The availability of tritium labeled cyproterone acetate (CPA) facilitated the systematic investigation of the binding characteristics of this compound for human uterine progesterone receptors (PgR). The binding parameters of 3H-CPA are compared to those of 3H-R5020 and 3H-progesterone. The rate constants of association (k1M-1sec-1) to PgR were 7.8 X 10(3) for 3H-R5020, 4.5 X 10(4) for 3H-progesterone and 4.0 X 10(4) for 3H-CPA. The rate constants of dissociation (k-1, sec-1) were 3.6 X 10(-5) for 3H-R5020, 21.3 X 10(-5) for 3H-progesterone and 17.8 X 10(-5) for 3H-CPA. The Kd-values (M), as obtained by titration analysis and subsequent Scatchard plot analysis were 1.2 X 10(-9) for 3H-R5020,…
From Clinical Imaging to Patient-Specific Computational Model: Rapid Adaptation of the Living Heart Human Model to a Case of Aortic Stenosis
2021
Aortic stenosis (AS) is the most common acquired heart valve disease in the developed world. Traditional methods of grading AS have relied on the measurement of aortic valve area and transvalvular pressure gradient. Recent research has highlighted the existence of AS variants that do not meet classic criteria for severe AS such as low-flow, low-gradient AS. With the development of sophisticated multi-scale computational models, investigation into the left ventricular (LV) biomechanics of AS offers new insights into the pathophysiology that may guide treatment decisions surrounding AS. Building upon our prior study entailing LV-aortic coupling where AS conditions were applied to the idealize…
Ventrolateral Compression of the Brain Stem in Essential Hypertension: MR Angiography Study
1997
Our purpose was to evaluate neurovascular compression at the level of ventrolateral medulla and NVC with the IXth and the Xth cranial nerves in patients with essential hypertension and in healthy volunteers using high resoluted Spoiled Recalled Gradient Echo (SPGR) sequences, allowing the detection of stationary tissues and moving spins. Thirty patients (19 men and 11 women) with essential hypertension were examined. Patient's ages ranged from 24 to 64 years-old (mean age was 48 y.o.). Patients older than 65 were excluded. The average of systolic blood-pressure of hypertensive patients was 183 ± 10 mmHg, while the diastolic pressure was 98 ± 10.5 mmHg. In conclusion, we consider axial sing…
Update on the role of the atherogenic lipoprotein phenotype in cardiovascular prevention
2009
Higher plasma triglyceride levels and decreased HDL-cholesterol concentrations are usually accompanied by the presence of small, dense LDL in the so-called lipid triad or ‘atherogenic lipoprotein phenotype’. This phenotype is highly atherogenic and its prevalence may suggest an even higher overall burden of atherosclerotic disease as compared with that associated with hypercholesterolemia. As stated by the National Cholesterol Education Program Adult Treatment Panel III, there is evidence suggesting each component of this lipid triad is individually atherogenic. However, the relative contribution of each component cannot be easily determined. Therefore, it has been suggested to consider th…
In vivo metabolism of LDL subfractions in patients with heterozygous FH on statin therapy
2004
LDL can be subfractionated into buoyant (1.020-1.029 g/ml(-1)), intermediate (1.030-1.040 g/ml(-1)), and dense (1.041-1.066 g/ml(-1)) LDLs. We studied the rebound of these LDL-subfractions after LDL apheresis in seven patients with heterozygous familial hypercholesterolemia (FH) regularly treated by apheresis (58 +/- 9 years, LDL-cholesterol = 342 +/- 87 mg/dl(-1), triglycerides = 109 +/- 39 mg/dl(-1)) and high-dose statins. Apolipoprotein B (apoB) concentrations were measured in LDL subfractions immediately after and on days 1, 2, 3, 5, and 7 after apheresis. Compartmental models were developed to test three hypotheses: 1) that dense LDLs are derived from the delipidation of buoyant and in…
Magnetic resonance in isolated noncompaction of the ventricular myocardium
2010
Abstract Non-compaction of the ventricular myocardium (LCVM) is a rare disorder of myocardial morphogenesis usually diagnosed in paediatric age. The diagnosis was echocardiographically made on the basis of a reported spongeous/compacted ratio >2 in one or more segments of the left ventricle during the diastolic period. We aimed to test the diagnostic accuracy of cardiovascular magnetic resonance (CMR) imaging in distinguishing pathological left ventricular non-compaction. Methods We collected a consecutive series of 8 patients, 5 males and 3 females, with a mean age of 14.9 years with non-compaction of left ventricular myocardium. All patients were admitted in our divisions of cardiology. I…
Gaismas un trokšņa piesārņojuma ietekme uz meža pūces Strix aluco sastopamību gar urbanizācijas gradientu: piemērs no Rīgas Latvijā
2017
Darba mērķis ir noskaidrot, kādi urbānās vides faktori ir svarīgi meža pūces dzīvotnes izvēlē pilsētvidē, vai gaismas un trokšņa piesārņojumam ir būtiska ietekme. Pētījumā izmantotas plaši pieejamas tālizpētes metodes, kas sniedz iespējas šo metodiku pielietot plašos reģionos un veikt datu interpretāciju. Veiktas uzskaites Rīgas administratīvās teritorijas robežās pūču telpiskās izplatības datu iegūšanais. Ar tālizpētes metodēm analizēti gaismas piesārņojuma un zemes virsmas seguma dati. Veikta vispārināto lineāro modeļu analīze meža pūces sastopamības prognozēšanai. Apsekotajās 173 vienībās kostatēti 40 meža pūces atsaukšanās gadījumi. Noskaidrots, ka meža pūces sastopamību urbānā vidē vis…
A new approach to calibrate the thermal conditions in space charge measurements on HVDC mini-cables
2019
The PEA method is currently widespread used for space charge measurements in mini-cables in order to qualify the behavior of semicon-dielectric-semicon compound under electric and thermal stress. The main goal of this research is to quantitatively evaluate the relationship between the thermal boundary conditions applied to cables or mini-cables and the maximum local electric field due to the accumulated space charge. Hitherto, several research groups have obtained thermal gradients over the dielectric's radius heating the conductor by Joule effect due to an induced current. In this paper, a numerical approach is offered to calibrate the heat exchange boundary conditions to apply to a sample…
Biogeographic patterns of base-rich fen vegetation across Europe
2014
International audience; Questions: What is the distribution of base-rich fen vegetation and the specia- list species along European biogeographic regions? How do the gradients in spe- cies composition correlate to geography and climate at continental scale? What are the implications of such patterns for the classification of these habitats?Location: Fifteen countries of Central, Western and Northern Europe.Methods: We compiled a vegetation plot database of base-rich fens and related communities including vascular plants and bryophytes. The initial data set with 6943 plots was filtered according to the presence of specialists using discriminant analysis. We used DCA to analyse the correlatio…
Classification of Targets Using Statistical Features from Range FFT of mmWave FMCW Radars
2021
Radars with mmWave frequency modulated continuous wave (FMCW) technology accurately estimate the range and velocity of targets in their field of view (FoV). The targeted angle of arrival (AoA) estimation can be improved by increasing receiving antennas or by using multiple-input multiple-output (MIMO). However, obtaining target features such as target type remains challenging. In this paper, we present a novel target classification method based on machine learning and features extracted from a range fast Fourier transform (FFT) profile by using mmWave FMCW radars operating in the frequency range of 77–81 GHz. The measurements are carried out in a variety of realistic situations, including p…