Search results for "Graft copolymer"

In situ gel forming graft copolymers of a polyaspartamide and polylactic acid: Preparation and characterization

2008

Abstract In situ gel forming systems have been prepared by linking polylactic acid (PLA) to a water soluble and polyfunctional polymer, such as α,β-poly( N -2-hydroxyethyl)- d , l -aspartamide (PHEA). Three graft copolymers PHEA–PLA with a different derivatization degree in PLA, have been synthesized and characterized. PHEA–PLA graft copolymer with the highest amount in PLA has been used to prepare solutions in organic solvents able to give rise to gel-like matrices when injected into phosphate buffered saline solution. The chemical degradation of these gels has been evaluated and in vitro tests have been performed to evaluate the cell compatibility of the hydrolysis products. The possibili…

Dexamethasone Dipropionate Loaded Nanoparticles Of -Elastin-G-Plga For Potential Treatment Of Restenosis

2013

EVALUATION OF BIODEGRADABILITY ON POLYSPARTAMIDE-POLYLACTIC ACID BASED NANOPARTICLES BY CHEMICAL HYDROLYSIS STUDIES POLYMER DEGRADATION AND STABILITY

2015

Here, the synthesis of two graft copolymers based on α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) and poly(lactic acid) (PLA), the O-(2-aminoethyl)-O′-galactosyl polyethylene glycol (GAL-PEG-NH2) or the methoxypolyethylene glycol amine (H2N-PEG-OCH3) is described. Starting from the obtained PHEA-PLA-PEG-GAL and PHEA-PLA-PEG copolymers, polymeric nanoparticles were prepared by high pressure homogenization–solvent evaporation method. To demonstrate their biodegradability as a function of the matrix composition, a chemical stability study was carried out until 21 days by incubating systems in two media mimicking physiological compartments (pH 7.4 and pH 5.5). The degradability of both nan…

Evaluation of biodegradability of novel polymeric nanoparticles based on amphiphilic polylactide-polyaspartamide derivatives.

2015