Search results for "Gram"

showing 10 items of 9069 documents

Effects of a home-based rehabilitation program in obese type 2 diabetics.

2012

International audience; OBJECTIVE: To assess, in obese type 2 diabetics (T2D), the impact of a home-based effort training program and the barriers to physical activity (PA) practice. METHOD: Twenty-three obese T2D patients (52.7 ± 8.2 years, BMI = 38.5 ± 7.6 kg/m(2)) were randomized to either a control group (CG), or an intervention group (IG) performing home-based cyclergometer training during 3 months, 30 min/day, with a monthly-supervised session. The initial and final measurements included: maximal graded effort test on cyclergometer, 6-minute walk test (6MWT) and 200-meter fast walk test (200mFWT), quadriceps maximal isometric strength, blood tests and quality of life assessment (SF- 3…

AdultMalemedicine.medical_specialtyQuadriceps strength030209 endocrinology & metabolismIsometric exerciseType 2 diabetes03 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitationQuality of lifeHumansMedicineOrthopedics and Sports MedicineMuscle StrengthObesityProspective Studies030212 general & internal medicineProspective cohort studyExerciseAgedbusiness.industry[SCCO.NEUR]Cognitive science/NeuroscienceRehabilitationMiddle Agedmedicine.disease3. Good healthTest (assessment)Diabetes Mellitus Type 2Home based rehabilitation[ SCCO.NEUR ] Cognitive science/NeuroscienceExercise TestPhysical therapyFemaleTraining programbusiness
researchProduct

Influence of metabolic syndrome on hypertension-related target organ damage

2005

MuleG, Nardi E, Cottone S, Cusimano P, Volpe V, Piazza G, MongioviR, Mezzatesta G, Andronico G, Cerasola G (Universitadi Palermo, Palermo, Italy). Influence of metabolic syndrome on hypertension-related target organ damage. J Intern Med 2005; 257: 503-513. Objectives. The aim of our study was to analyse, in a wide group of essential hypertensive patients without diabetes mellitus, the influence of metabolic syndrome (MS) (defined according to the criteria laid down in the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults) on markers of preclinical cardiac, renal and retinal damage. Design. Cros…

AdultMalemedicine.medical_specialtySettore MED/09 - Medicina InternamicroalbuminuriaHeart VentriclesRetinographyLeft ventricular hypertrophyEssential hypertensionKidneyRetinametabolic syndromeHypertensive retinopathyRetinal Diseasesessential hypertension;left ventricular hypertrophy;metabolic syndrome;microalbuminuria;target organ damageInternal medicinetarget organ damageInternal MedicinemedicineAlbuminuriaHumansObesitySex DistributionNational Cholesterol Education ProgramAntihypertensive AgentsBody surface areaSettore MED/14 - Nefrologiabusiness.industryMyocardiumessential hypertensionMiddle Agedmedicine.diseaseSettore MED/11 - Malattie Dell'Apparato Cardiovascolareleft ventricular hypertrophyEndocrinologyCross-Sectional StudiesHypertensionCardiologyRegression AnalysisMicroalbuminuriaFemaleHypertrophy Left VentricularMetabolic syndromebusiness
researchProduct

Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial.

2021

Summary Background Before February, 2021, there was no standard treatment regimen for locally advanced basal cell carcinoma after first-line hedgehog inhibitor (HHI) therapy. Cemiplimab, a PD-1 antibody, is approved for treatment of advanced cutaneous squamous cell carcinoma and has shown clinical activity as monotherapy in first-line non-small-cell lung cancer. Here, we present the primary analysis data of cemiplimab in patients with locally advanced basal cell carcinoma after HHI therapy. Methods We did an open-label, multicentre, single-arm, phase 2 trial across 38 outpatient clinics, primarily at academic medical centres, in Canada, Europe, and the USA. Eligible patients (aged ≥18 years…

AdultMalemedicine.medical_specialtySkin NeoplasmsPyridinesProgrammed Cell Death 1 ReceptorVismodegibAntibodies Monoclonal Humanized030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineInternal medicineAntineoplastic Combined Chemotherapy ProtocolsmedicineCarcinomaClinical endpointOutpatient clinicHumansBasal cell carcinomaAnilidesHedgehog ProteinsLung cancerImmune Checkpoint InhibitorsAgedbusiness.industryStandard treatmentMiddle Agedmedicine.diseaseRegimenOncologyCarcinoma Basal CellDrug Resistance Neoplasm030220 oncology & carcinogenesisFemaleNeoplasm Recurrence LocalSettore MED/35 - MALATTIE CUTANEE E VENEREEbusinessmedicine.drugThe Lancet. Oncology
researchProduct

Regular rhythmic primes boost P600 in grammatical error processing in dyslexic adults and matched controls

2020

International audience; Regular musical rhythms orient attention over time and facilitate processing. Previous research has shown that regular rhythmic stimulation benefits subsequent syntax processing in children with dyslexia and specific language impairment. The present EEG study examined the influence of a rhythmic musical prime on the P600 late evoked-potential, associated with grammatical error detection for dyslexic adults and matched controls. Participants listened to regular or irregular rhythmic prime sequences followed by grammatically correct and incorrect sentences. They were required to perform grammaticality judgments for each auditorily presented sentence while EEG was recor…

AdultMalemedicine.medical_specialtySyntax processingCognitive NeuroscienceExperimental and Cognitive PsychologySpecific language impairmentAudiology050105 experimental psychologyDyslexiaYoung Adult03 medical and health sciencesBehavioral Neuroscience[SCCO]Cognitive science0302 clinical medicineRhythmTemporal attentionmedicineHumans0501 psychology and cognitive sciencesEvoked PotentialsRhythmic primingCerebral CortexP600PsycholinguisticsP600 evoked potentialDyslexia P600 evoked potential Rhythmic priming Syntax processing Temporal attention05 social sciencesDyslexiaElectroencephalographymedicine.diseaseSyntax[SCCO.PSYC]Cognitive science/PsychologyAuditory PerceptionSpeech PerceptionFemaleGrammaticalityPsychologyPriming (psychology)Music030217 neurology & neurosurgerySentence
researchProduct

Central and Peripheral Contributions to Fatigue after Electrostimulation Training

2006

Purpose: We examined the effect of 4 (WK4) and 8 wk (WK8) of neuromuscular electrical stimulation (NMES) training on both endurance time and mechanisms contributing to task failure. Methods: Ten males performed a fatiguing isometric contraction with the knee extensor muscles at 20% of maximal voluntary contraction (MVC) until exhaustion before (B), at WK4, and at WK8 of NMES training. The electromyographic (EMG) activity and muscle activation obtained under MVC were recorded before and after the fatiguing task to assess central fatigue. Torque and EMG responses obtained under electrically evoked contractions were examined before and after the fatiguing task to analyze peripheral fatigue. Re…

AdultMalemedicine.medical_specialtyTime FactorsContraction (grammar)Neuromuscular JunctionPhysical Therapy Sports Therapy and RehabilitationIsometric exerciseElectromyographyFeedbackVoluntary contractionPhysical medicine and rehabilitationIsometric ContractionmedicineHumansOrthopedics and Sports MedicineMuscle Skeletalmedicine.diagnostic_testKnee extensorsElectromyographybusiness.industryReproducibility of ResultsSignal Processing Computer-AssistedMuscle activationmusculoskeletal systemElectric StimulationRate of increasePeripheralTorquePhysical FitnessMuscle FatiguePhysical EndurancebusinessFemoral NerveMuscle ContractionMedicine & Science in Sports & Exercise
researchProduct

Neuromuscular fatigue differs with biofeedback type when performing a submaximal contraction

2007

The aim of the study was to examine alterations in contractile and neural processes in response to an isometric fatiguing contraction performed with EMG feedback (constant-EMG task) when exerting 40% of maximal voluntary contraction (MVC) torque with the knee extensor muscles. A task with a torque feedback (constant-torque task) set at a similar intensity served as a reference task. Thirteen men (26+/-5 yr) attended two experimental sessions that were randomized across days. Endurance time was greater for the constant-EMG task compared with the constant-torque task (230+/-156 s vs. 101+/-32s, P0.01). Average EMG activity for the knee extensor muscles increased from 33.5+/-4.5% to 54.7+/-21.…

AdultMalemedicine.medical_specialtyTime FactorsContraction (grammar)medicine.medical_treatmentBiophysicsNeuroscience (miscellaneous)Isometric exerciseBiofeedbackbehavioral disciplines and activitiesFeedbackSubmaximal contractionPhysical medicine and rehabilitationIsometric ContractionmedicineHumansKneeEmg biofeedbackRehabilitationKnee extensorsElectromyographybusiness.industrymusculoskeletal systemTorqueNeuromuscular fatigueMuscle FatiguePhysical EnduranceNeurology (clinical)businesspsychological phenomena and processesJournal of Electromyography and Kinesiology
researchProduct

Neuromuscular adaptations to combined strength and endurance training: order and time-of-day

2017

AbstractThe present study examined the effects of 24 weeks of morning vs. evening same-session combined strength (S) and endurance (E) training on neuromuscular and endurance performance. Fifty-one men were assigned to the morning (m) or evening (e) training group, where S preceded E or vice versa (SEm, ESm, SEe and ESe), or to the control group. Isometric force, voluntary activation, EMG and peak wattage during the maximal cycling test were measured. Training time did not significantly affect the adaptations. Therefore, data are presented for SEm+e (SEm+SEe) and ESm+e (ESm+ESe). In the morning, no order specific gains were observed in neuromuscular performance. In the evening, the changes …

AdultMalemedicine.medical_specialtyTime FactorsEveningDiurnal rhythmsVoluntary activationTraining timePhysical Therapy Sports Therapy and RehabilitationElectromyographyIsometric exercise03 medical and health sciences0302 clinical medicineAnimal scienceTime of dayEMGEndurance trainingmedicineHumansKneeOrthopedics and Sports MedicineConcurrent trainingMuscle forceMuscle StrengthMuscle SkeletalMorningmedicine.diagnostic_testElectromyographyChemistryResistance Training030229 sport sciencesAdaptation PhysiologicalExercise TestPhysical EndurancePhysical therapyTraining program030217 neurology & neurosurgery
researchProduct

Large left ventricular metastatis in patient with liposarcoma.

2014

Abstract Metastasis to the heart and pericardium are rare. We present a 44-year-old male with pleural dedifferentiated liposarcoma and multiple metastases, with no previous cardiological history and/or cardiac symptoms. A transthoracic echocardiogram during the advanced stage of disease showed a lobulated, large and mobile mass, with homogeneous echogenicity, attached to the basal posterior wall of the left ventricle via a broad base and with intracavitary growth. This mass extends to inferolateral and inferoseptal wall of the left ventricle.

AdultMalemedicine.medical_specialtyTime FactorsLarge left ventricular metastasiBiopsyHeart VentriclesPleural Neoplasms030204 cardiovascular system & hematologyDoppler echocardiographyLiposarcomaMetastasisHeart Neoplasms03 medical and health sciencesFatal Outcome0302 clinical medicineHumansMedicinePericardium030212 general & internal medicinePleural Neoplasmheart metastases liposarcomamedicine.diagnostic_testbusiness.industryEchogenicityGeneral Medicinemedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareEchocardiography DopplerTumor Burdenmedicine.anatomical_structureVentricleliposarcomaDisease Progressioncardiovascular systemRadiologyTransthoracic echocardiogramTomography X-Ray ComputedCardiology and Cardiovascular Medicinebusiness
researchProduct

Individual music therapy for depression: randomised controlled trial

2011

BackgroundMusic therapy has previously been found to be effective in the treatment of depression but the studies have been methodologically insufficient and lacking in clarity about the clinical model employed.AimsTo determine the efficacy of music therapy added to standard care compared with standard care only in the treatment of depression among working-age people.MethodParticipants (n= 79) with an ICD–10 diagnosis of depression were randomised to receive individual music therapy plus standard care (20 bi-weekly sessions) or standard care only, and followed up at baseline, at 3 months (after intervention) and at 6 months. Clinical measures included depression, anxiety, general functioning…

AdultMalemedicine.medical_specialtyTime FactorsMusic therapyAdolescentAnxietySeverity of Illness Indexlaw.inventionYoung Adult03 medical and health sciences0302 clinical medicineQuality of life (healthcare)Randomized controlled triallawSeverity of illnessmedicineHumansAffective Symptoms030212 general & internal medicinePsychiatryMusic TherapyFinlandDepression (differential diagnoses)ta515Psychiatric Status Rating ScalesDepressive DisorderIntention-to-treat analysisOdds ratioMiddle Agedta3124Intention to Treat Analysis030227 psychiatryPsychiatry and Mental healthOutcome and Process Assessment Health Careta6131Quality of LifePhysical therapyPsychotherapy BriefAnxietyFemalemedicine.symptomPsychologyProgram EvaluationThe British Journal of Psychiatry
researchProduct

Neural drive preservation after detraining following neuromuscular electrical stimulation training

2006

The purpose of the study was to investigate the behaviour of the central nervous system when 5 weeks of neuromuscular electrical stimulation (NMES) training was followed by 5 weeks of detraining. Nineteen males were divided into the neuromuscular electrostimulated group (EG, n=12) and the control group (CG, n=7). The training program consisted of 15 sessions of isometric NMES over a 5-week period. The EG subjects were tested before training (PRE), after 5 weeks of NMES training (POST) and after 5 weeks of detraining (DE) while CG subjects were only tested at PRE and at POST. Soleus (SOL) and gastrocnemii (GAS) maximal H-reflex and M-wave potentials were evoked at rest (i.e., H(max) and M(ma…

AdultMalemedicine.medical_specialtyTime FactorsPhysical ExertionStimulationIsometric exercisePlantar flexionH-ReflexVoluntary contractionPhysical medicine and rehabilitationHumansMedicineMuscle SkeletalNeuronal Plasticitybusiness.industryGeneral NeuroscienceMuscle activationEvoked Potentials MotorAdaptation PhysiologicalElectric StimulationSupramaximal stimulationPhysical FitnessAnesthesiaH-reflexTraining programbusinesshuman activitiesAnkle JointMuscle ContractionNeuroscience Letters
researchProduct