Search results for "Gram"
showing 10 items of 9069 documents
Overexpression of genes involved in lymphocyte activation and regulation are associated with reduced CRM-derived cardiac remodelling after STEMI
2021
Abstract Aims Lymphopenia after ST-segment elevation myocardial infarction (STEMI) correlates with deleterious cardiac consequences and worse prognosis. An in-depth examination of genes implicated in lymphocyte proliferation, activation and regulation and their association with short- and long-term cardiac structure and function is therefore of great interest. Methods Peripheral blood mononuclear cells were isolated from 10 control subjects and 64 patients with a first STEMI treated with primary percutaneous coronary intervention and submitted to cardiac magnetic resonance after 1 week and 6 months. mRNA expression of genes implicated in lymphocyte activation (CD25 and CD69) and regulation …
Programmi di clemenza e azione risarcitoria: convivenza possibile?
2014
This work stems from the European Directive on antitrust damages actions and enquires on the need to preserve the effectiveness of antitrust public and private enforcement within the framework of the relationship between the leniency programmes and actions for damages. As is well known, the leniency programmes allow companies involved in an agreement prohibited by competition law to cooperate with competent Antitrust Authority in order to disclose such an infringement and obtain the immunity or a reduction from fines. This generates the need to preserve the secrecy of leniency statements in order to not deter companies from using such a programme. The Directive provides, inter alia, that na…
L'Autorità garante della concorrenza e del mercato ei prgrammi di clemenza
2010
A distanza di tre anni dall'introduzione dei programmi di clemenza nella legge antitrust italiana, si impone una riflessione sui problemi aperti dalla loro adozione e applicazione. Il contributo li esamina, comparando il sistema italiano con quello comunitario e con gli altri sistemi vigenti nell'ambito dell'ECN. Evidenzia, quindi, alcuni aspetti critici della disciplina italiana, relativi all'accesso dei terzi alle dichiarazioni confessorie e alla documentazione allegata.
Antitumoural Properties of Benzannelated Seven -Membered 5-fluorouracil Derivatives and Related Open Analogues. Molecular Markers for Apoptosis and C…
2005
Attention is increasingly being focussed on the cell cycle and apoptosis as potential targets for therapeutic intervention in cancer. We prepared a series of bioisosteric benzannelated seven-membered 5-FU O,N-acetals to test them against the MCF-7 human breast cancer cell line. Benzo-fused seven-membered O,O-acetals or their acyclic analogues led to the expected 5-FU O,N-acetals (or aminals), in addition to six- and 14-membered aminal structures and acyclic compounds. All the cyclic aminals provoked a G0/G1-phase cell cycle arrest, whereas Ftorafur, a known prodrug of 5-FU, and 1-[2-(2-hydroxymethyl-4-nitrophenoxy)-1-methoxyethyl]-5-fluorouracil (11) induced an S-phase cell cycle arrest. Al…
A Tool for Predicting the Dynamic Response of Biotrickling Filters for VOC Removal
2016
This article presents the development of a MATLAB® computer program to simulate the performance of biotrickling filters. Since these filters behave differently during spraying and nonspraying cycles, the presented simulation tool is built on top of a mathematical description of each situation. The resulting variable-structure model is then used as the basis for simulation experiments. The model presented herein represents the first attempt to take into account the variable spraying pattern usually found in industrial installations. Overall, the software is flexible and easy to use, allowing the user to specify the emission concentration pattern, the gas concentration pattern, as well as the…
Un testigo del arte barroco "novator" valenciano de "La Vall de Gallinera": la iglesia parroquial de San Miguel de Benissivà
2002
El estudio nos presenta una muestra de recuperación de artesanías tradicionales en el medio rural como proyecto de enseñanza-aprendizaje de la Universitat de València y su Área de Conservació del Patrimoni Cultural, desde unos análisis histórico-material, histórico-artístico y técnico, en torno a la intervención llevada a cabo en la iglesia de San Miguel de Benissivà de Alicante. Buscando su valoración dentro del conjunto patrimonial al cual pertenece, se acomete una investigación sobre dicho templo y sus transformaciones, sus orígenes, evolución y creadores (entendidos dentro de la etapa artística valenciana de esplendor barroco y clasicismo matemático en la que se encuentran inmiscuidos),…
Changes in Adrenoceptors and G-Protein-Coupled Receptor Kinase 2 in <smlcap>L</smlcap>-NAME-Induced Hypertension Compared to Spontaneous …
2014
This work compares the expression of adrenoceptors (ARs) and G-protein-coupled receptor kinase (GRK) 2 (RT-PCR and immunoblotting) and functional responses in conductance (aorta) and resistance vessels (mesenteric resistance arteries; MRA) in two different models of rat hypertension: hypertension induced by chronic treatment with <smlcap>L</smlcap>-NAME (N<sup>G</sup>-nitro-<smlcap>L</smlcap>-arginine methyl-ester) (<smlcap>L</smlcap>-NAME-treated rats; LNHR), and genetically induced hypertension (spontaneously hypertensive rats; SHR). Changes found in the aorta, but not in the MRA, were: (1) a loss of contractile capacity, more evidently in α…
AB0564 HEART VALVULAR ALTERATIONS IN A MULTICENTRE ITALIAN COHORT OF SSC PATIENTS
2020
Background:systemic sclerosis (SSc) in a chronic autoimmune disease characterized by endothelial dysfunction, diffuse microangiopathy, and fibrosis of skin and visceral organs. Typical cardiac involvement may includes microvascular ischemia, contraction band necrosis, and patchy fibrosis, leading mainly to arrythmias and conduction defects, diastolic dysfunction, or right ventricular failure (secondary to pulmonary arterial hypertension) [1]. Valvular diseases are poorly described and generally not considered a typical sign of SSc [2-4].Objectives:we aimed to describe valvular alterations in a multicentre cohort of SSc patients.Methods:we consecutively recruited 118 SSc patients (M/F: 14/10…
Life Cycle Assessment of an Ambitious Renovation of a Norwegian Apartment Building to nZEB Standard
2018
Author's accepted manuscript. The upgrading of building infrastructure to modern standards represents a key tool for reducing global energy demand and emissions from buildings. In Norway, building upgrades have been prioritized despite the relatively low carbon intensity of the Norwegian energy mix through various incentive programs and continual improvement in building standards. Prioritizing upgrades is important as up to 90% of the existing Norwegian building stock is expected to remain standing by the year 2050. The overall impact of upgrading buildings is expected to be a net benefit to the environment but this is primarily in operation, and many studies on energy do not include the ma…
Neuronal cell cycle: the neuron itself and its circumstances.
2015
Neurons are usually regarded as postmitotic cells that undergo apoptosis in response to cell cycle reactivation. Nevertheless, recent evidence indicates the existence of a defined developmental program that induces DNA replication in specific populations of neurons, which remain in a tetraploid state for the rest of their adult life. Similarly, de novo neuronal tetraploidization has also been described in the adult brain as an early hallmark of neurodegeneration. The aim of this review is to integrate these recent developments in the context of cell cycle regulation and apoptotic cell death in neurons. We conclude that a variety of mechanisms exists in neuronal cells for G1/S and G2/M check…