Search results for "Grit"
showing 10 items of 192 documents
Fonti, suggestioni e intersezioni classiche, tardoantiche e medievali nell’«Alda» di Guglielmo di Blois
2019
In questo saggio vengono studiate le fonti classiche, tardoantiche e medievali dell’«Alda», commedia elegiaca latina di Guglielmo di Blois (scritta verso il 1169-1170). In particolare, dopo una presentazione generale dell’opera e una rassegna critica degli studi e delle edizioni, ci si sofferma sulle suggestioni attinte a Terenzio, Virgilio, Orazio, Ovidio, Stazio, all’«Aegritudo Perdicae», Massimiano, Boezio, Ildeberto di Lavardin, ad alcune commedie elegiache del sec. XII (il «Geta» e l’«Aulularia» di Vitale di Blois, il «Pamphilus», la «Lidia» di Arnolfo d’Orléans) e alla tradizione novellistica “orientale” («Mischle Sendebar»). This essay is founded on the classical, late and medieval s…
Efficacy and safety of bempedoic acid for the treatment of hypercholesterolemia: A systematic review and meta-analysis
2020
Background Bempedoic acid is a first-in-class lipid-lowering drug recommended by guidelines for the treatment of hypercholesterolemia. Our objective was to estimate its average effect on plasma lipids in humans and its safety profile. Methods and findings We carried out a systematic review and meta-analysis of phase II and III randomized controlled trials on bempedoic acid (PROSPERO: CRD42019129687). PubMed (Medline), Scopus, Google Scholar, and Web of Science databases were searched, with no language restriction, from inception to 5 August 2019. We included 10 RCTs (n = 3,788) comprising 26 arms (active arm [n = 2,460]; control arm [n = 1,328]). Effect sizes for changes in lipids and high-…
Gli atti di disposizione
2013
Il saggio prende in esame la disciplina degli atti di disposizione del proprio corpo nella prospettiva del limite che essa pone all'autonomia dei privati, scrutinandone il significato e la portata attuali alla luce dei mutamenti intervenuti nel sistema, dopo il varo dell'art. 5 del codice civile, anche per effetto della normativa comunitaria e, in particolare, della Carta dei diritti fondamentali dell'Unione europea. Specola privilegiata di indagine sono le previsioni in materia di consenso nelle fattispecie dispositive di organi, di cellule e tessuti umani a destinati ad applicazioni (trapianto, innesto, infusione) su soggetti terzi. Nel persistente richiamo della normativa di settore a li…
Attacks Against the WAP WTLS Protocol
1999
The WAP WTLS protocol was designed to provide privacy, data integrity, and authentication for wireless terminals. The protocol is currently being fielded, and it is expected that the protocol will be contained in millions of devices in a few years.
Look for methods, not conclusions
2019
Qualunque sia l'esito effettivo di un'indagine su un caso di presunta manipolazione dei dati, ci sono alcuni principi fermi che sono sempre veri e alcuni errori che devono essere evitati.
Biotensegrity of the Extracellular Matrix: Physiology, Dynamic Mechanical Balance, and Implications in Oncology and Mechanotherapy
2014
Cells have the capacity to convert mechanical stimuli into chemical changes. This process is based on the tensegrity principle, a mechanism of tensional integrity. To date, this principle has been demonstrated to act in physiological processes such as mechanotransduction and mechanosensing at different scales (from cell sensing through integrins to molecular mechanical interventions or even localized massage). The process involves intra- and extracellular components, including the participation of extracellular matrix (ECM) and microtubules that act as compression structures, and actin filaments which act as tension structures. The nucleus itself has its own tensegrity system which is impli…
Experimental assessment of the hydro-mechanical behaviour of a shale caprock during CO2 injection
2021
Abstract The presented experimental study focuses on the hydro-mechanical characterisation of a shale caprock (Opalinus Clay) in contact with carbon dioxide. The objective of this paper, consists in the evaluation of the material's sealing capacity in terms of entry-pressure, mechanical behaviour and sensitivity of the transport properties to chemo-mechanical effects induced by gaseous and liquid CO2 injection. Two types of Opalinus Clay core samples are tested; shaly and carbonate-rich. The sealing capacity has been evaluated on the shaly OPA according to the stepwise and the residual methods and compared to the results from mercury intrusion porosimetry. The obtained results and the diffe…
Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness
2021
Objective Recently, increasing epidemiological evidence has shown that there is a correlation between serum uric acid level (SUA) and carotid intima-media thickness (CIMT). This paper explored the relationship between them through meta-analysis. Methods PubMed, Cochrane Library, EMBASE, Web of Science and Google Scholar were searched to obtain literature. The keywords used to retrieve the literature were carotid intima thickness, intima-media thickness, carotid atherosclerosis, carotid stenosis, carotid artery, uric acid, blood uric acid, and hyperuricaemia. The retrieval time was from the establishment of the database through July 2020. Stata15.0 and RevMan5.3 software were used for stati…
The yeast mitogen-activated protein kinase Slt2 is involved in the cellular response to genotoxic stress
2012
Abstract Background The maintenance of genomic integrity is essential for cell viability. Complex signalling pathways (DNA integrity checkpoints) mediate the response to genotoxic stresses. Identifying new functions involved in the cellular response to DNA-damage is crucial. The Saccharomyces cerevisiae SLT2 gene encodes a member of the mitogen-activated protein kinase (MAPK) cascade whose main function is the maintenance of the cell wall integrity. However, different observations suggest that SLT2 may also have a role related to DNA metabolism. Results This work consisted in a comprehensive study to connect the Slt2 protein to genome integrity maintenance in response to genotoxic stresses.…
Promoting and Assessing Integrity in the Research Degree
2008
Although postgraduate research is increasingly supported through the formalisation of supervision and programs providing generic support, those programs have seldom addressed the intention, often stated by universities in their graduate profiles, that postgraduates should have integrity, and ethical values. What methodology is required – how will universities support students to cultivate such sensitivity, assess this, and fulfill the expectation? The paper provides evidence that quality statements including some aspect of integrity are used in many UK and Australian universities. The importance of integrity, or ethical behaviour more generally, in postgraduate degrees and in professional p…