Search results for "Guanine-Quartets"
showing 2 items of 2 documents
Guanine Assemblies on the Au(111) Surface: A Theoretical Study
2013
It was found previously [Small2009, 5, 1952 and Angew. Chem., Int. Ed.2005, 44, 2270] that guanine molecules when assembled in a vacuum on the Au(111) surface at room temperature form a hydrogen-bonded network consisting of guanine quartets of the same chirality; this was supported by ground-state density functional theory (DFT) gas-phase calculations. In this Article, we re-examine this system and show that many more (almost equally stable) both homo- and heterochiral structures are possible; however, the homochiral structure observed experimentally becomes definitely the most favorable only if the vibrational contribution to the free energy is accounted for. Interaction with the gold surf…
Applications of guanine quartets in nanotechnology and chemical biology
2019
Guanine and related nucleobases such as guanosine, deoxyguanosine and isoguanosine are notable molecular tools for designing functional supramolecular assemblies. This popularity originates in their ability to self-assemble via a unique topological pluralism — as isolated nucleobases, discrete macrocyclic quartets and virtually infinite linear ribbons — that endows them with a considerable functional versatility. Many programmes have been launched to fine-tune the chemical properties of guanine derivatives, to make them usable under different experimental conditions, such as in organic or aqueous environments, and responsive to external stimuli, such as ionic strength, pH, light or temperat…