Search results for "Guida"

Dscam1 Is Required for Normal Dendrite Growth and Branching But Not for Dendritic Spacing in Drosophila Motoneurons

2014

Down syndrome cell adhesion molecule, Dscam, serves diverse neurodevelopmental functions, including axon guidance and synaptic adhesion, as well as self-recognition and self-avoidance, depending on the neuron type, brain region, or species under investigation. InDrosophila, the extensive molecular diversity that results from alternative splicing of Dscam1 into >38,000 isoforms provides neurons with a unique molecular code for self-recognition in the nervous system. Each neuron produces only a small subset of Dscam1 isoforms, and distinct Dscam1 isoforms mediate homophilic interactions, which in turn, result in repulsion and even spacing of self-processes, while allowing contact with neig…

Neuronal polarization is impaired in mice lacking RhoE expression

2012

J. Neurochem. (2012) 121, 903–914. Abstract Proper development of neuronal networks relies on the polarization of the neurons, thus the establishment of two compartments, axons and dendrites, whose formation depends on cytoskeletal rearrangements. Rnd proteins are regulators of actin organization and they are important players in several aspects of brain development as neurite formation, axon guidance and neuron migration. We have recently demonstrated that mice lacking RhoE/Rnd3 expression die shortly after birth and have neuromotor impairment and neuromuscular alterations, indicating an abnormal development of the nervous system. In this study, we have further investigated the specific ro…

The evolution of the European Union law on the criminalization of humanitarian assistance to irregular migrants: From the council directive 2002/90/C…

2021

With the new Pact on Migration and Asylum, the European Commission published the Guidance C(2020) 6470 of 23 September 2020 on the implementation of EU rules on definition and prevention of the facilitation of unauthorised entry, transit and residence. The present contribution shows as this guidance proposes an interpretation of the article 1 of the Council Directive 2002/90/CE, which only partially meets the problem of the criminalization of humanitarian assistance to irregular migrants, since it has shortcomings both at material and at formal level. After an analysis concerning the guidance capacity to impact on the Court of Justice and national judges case-law, the article ends with some…

Guida in stato di ebbrezza, irrilevanza della clausola di sussidiarietà e concorso di reati: una discutibile impostazione della costante giurispruden…

2011

Il Percorso Diagnostico Terapeutico Assistenziale del paziente con melanoma metastatico presso l’Azienda Ospedaliera Universitaria Policlinico Paolo …

2017

L’evoluzione dello scenario internazionale relativo alla sanità identifica cinque specifiche dimensioni come driver del cambiamento: il sistema, la finanza, le persone, i processi e la tecnologia. In linea con tali elementi, il patto per la salute 2014-2016 esplicita la necessità di una rivisitazione a tutti i livelli del sistema salute, sia organizzativo che gestionale, con l’intento di aumentare l’efficienza e l’efficacia, sviluppando nuovi modelli assistenziali, anche nella logica delle reti cliniche, dove tra gli “strumenti” viene identificata l’attivazione di Percorsi Diagnostico Terapeutico Assistenziali (PDTA). I percorsi condivisi e codificati per i vari stadi di patologia, con un s…

Absolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancer

2016

International audience; Background: To determine whether dose/volume specific endpoints (DVSE) or Area under the rectal DVH curve (rAUC) better predict acute gastrointestinal (GI) toxicity in prostate cancer patients treated with IMRT in the era of daily image guidance (IG-IMRT). Methods: A set of DVSE was recorded from V25 to V75 (increments of 5Gy) (both in % and in cc) for 180 men. The rAUC was calculated for doses ranging between 25Gy and 50Gy (rAUC(25-50)). Univariate and multivariate logistic regressions were performed to determine the relationship between DVSE or rAUC(25-50) and the appearance of any acute GI toxicity. Results: The rates of acute grade 1 (G1), G2 and G3 GI toxicities…

Towards practical reflexivity in online discussion groups

2017

This paper continues the discussion about student-driven, interactive learning activities in higher education. Using object-oriented activity theory, the article explores the relational aspects of reflexive practice as demonstrated in five online discussions groups to develop students’ conceptual understanding. The purpose of the research is to describe both the process of reflection during online interaction and how practical engagement with the discipline is supported through pedagogical guidance. The students wrote short texts on the practice of health promotion ethics and discussed their perspectives in relation to theory and research. The analysis proved the importance of structural de…

The Italian Version of the Career Factors Inventory

2015

This study attempted to examine the validity of the Italian version of the Career Factors Inventory (CFI), a psychometric tool widely used in the assessment of cognitive and personal–emotional dimensions of career indecision, among a sample of 2,060 Italian students attending high school and university. Recurring to both exploratory and confirmatory factor analyses, the original four-factor structure was confirmed and returned, in line with the literature, satisfactory reliability indices; moreover, CFI subscales showed intercorrelations consistent with previous studies, albeit lower in some cases. Subsequently, convergent validity between the four CFI subscales and other scales via zero-o…

L'orientation : que nous dit la comparaison avec les USA ?

2008

08008; Les idées et l'organisation de l'école française sont ici très sérieusement interrogées, surtout quand on en compare ses performances avec celles des USA.

French Endocrine Society Guidance on endocrine side effects of immunotherapy.

2018

The management of cancer patients has changed due to the considerably more frequent use of immune checkpoint inhibitors (ICPIs). However, the use of ICPI has a risk of side effects, particularly endocrine toxicity. Since the indications for ICPI are constantly expanding due to their efficacy, it is important that endocrinologists and oncologists know how to look for this type of toxicity and how to treat it when it arises. In view of this, the French Endocrine Society initiated the formulation of a consensus document on ICPI-related endocrine toxicity. In this paper, we will introduce data on the general pathophysiology of endocrine toxicity, and we will then outline expert opinion focusing…