Search results for "Guide"
showing 10 items of 1478 documents
Design of Bimodal Ligands of Neurotensin Receptor 1 for Positron Emission Tomography Imaging and Fluorescence-Guided Surgery of Pancreatic Cancer
2020
International audience; Neurotensin receptor 1 (NTSR1) is overexpressed in most human pancreatic ductal adenocarcinomas. It makes it an attractive target for the development of pancreatic cancer imaging agents. In this study, we sought to develop a bimodal PET-fluorescent imaging agent capable of specifically targeting these receptors. Starting from the structure of a known NTSR1 agonist, a series of tracers was synthesized, radiometalated with gallium-68 and evaluated in vitro and in vivo, in mice bearing an AsPC-1 xenograft. PET imaging allowed us to identify the compound [ 68 Ga]Ga-NODAGA-Lys(Cy5**)-AEEAc-[Me-Arg 8 , Tle 12 ]-NT(7-13) as the one with the most promising biodistribution pr…
Topical estrogens and non-hormonal preparations for postmenopausal vulvovaginal atrophy: An EMAS clinical guide
2021
Introduction: Vulvovaginal atrophy (VVA) is a chronic condition caused by estrogen deficiency. It affects around 50% of postmenopausal women, reducing their general and sexual quality of life as well as the quality of their personal relationships. Aim: The aim of this clinical guide is to set out an individualized approach to the management of VVA with topical estrogens and non-hormonal preparations. Materials and methods: Literature review and consensus of expert opinion. Summary recommendations: An individualized approach is required for the management of VVA. Topical low-dose estrogens are effective and also alleviate urinary incontinence and prevent recurrent urinary tract infections. W…
Pratica clinica e aderenza a Linee Guida nella diagnosi e terapia delle neoplasie vescicali non muscolo-invasive: report di uno studio ricognitivo ba…
2015
Clinical practice and adherence to the diagnosis and treatment of NMIBC guidelines: a report of a recognition based clinical cases study For non-muscle invasive bladder cancer, a disease with a considerable epidemiological and socio-economic impact, the introduction of the Guidelines has always evoked as a tool for the resolution of long-standing disputes in terms of diagnosis and therapy. Check the degree of routine clinical practice adherence to the Recommendations is for this disease, more than for other uro-oncology pathology, an urgent need felt by the urological community. To assess the level of Guidelines adherence’s, and study issues related to the paths of diagnosis and treatment o…
Exploring titanium dioxide as a new photonic platform
2019
International audience; We report the development of titanium dioxide-based waveguides for applications in the near-and mid-infrared. Thanks to embedded metal grating couplers, we demonstrate error free 10 Gbit/s optical transmissions at 1.55 and 2 µm. We also demonstrate octave-spanning supercontinuum in cm-long waveguides. We explore the way to improve such waveguides through optimized fabrication process.
Guided-wave frequency doubling in surface periodically poled lithium niobate: competing effects
2007
We carried out second-harmonic generation in quasi-phase-matched ? -phase lithium niobate channel waveguides realized by proton exchange and surface periodic poling. Owing to a limited ferroelectric domain depth, we could observe the interplay between second-harmonic generation and self-phase modulation due to cascading and cubic effects, resulting in a nonlinear resonance shift. Data reduction allowed us to evaluate both the quadratic nonlinearity in the near infrared as well as the depth of the uninverted domains. © 2007 Optical
FIBER AND GUIDED WAVE OPTICS | Nonlinear Effects (Basics)
2005
The development and status of the IGISOL technique
1997
Abstract The development of the IGISOL technique since its earliest beginnings at the University of Jyvaskyla in the early '80s is reviewed. The processes involved in ion survival in the ion guide are discussed. The design and performance of ion guides for different types of reactions is summarised. The mass-separated beam quality for different skimmer systems is compared.
Off-line studies of the laser ionization of yttrium at the IGISOL facility
2007
A laser ion source is under development at the IGISOL facility, Jyvaskyla, in order to address deficiencies in the ion guide technique. The key elements of interest are those of a refractory nature, whose isotopes and isomers are widely studied using both laser spectroscopic and high precision mass measurement techniques. Yttrium has been the first element of choice for the new laser ion source. In this work we present a new coupled dye-Ti:Sapphire laser scheme and give a detailed discussion of the results obtained from laser ionization of yttrium atoms produced in an ion guide via joule heating of a filament. The importance of not only gas purity, but indeed the baseline vacuum pressure in…
Design of a High-Efficiency Ka-Band TWT Power Amplifier for Radar Applications
2022
The design of a high-efficiency Traveling Wave Tube (TWT) based on a non-conventional folded waveguide slow-wave structure (FW-SWS) operating over 34-36 GHz for naval and ground Ka-band radars is presented. The ridge vane-loaded FW structure allows a good compromise between high interaction impedance and wide bandwidth along with a low weight required for aircraft radar applications and a simple planar manufacturing process structure. Small signal simulations are performed with a custom interaction impedance evaluation program. The CST suite 2021 3D electromagnetic simulation code is used for the prediction of the dispersion diagram. Starting from a sensitivity analysis of the folded wavegu…
First collinear laser spectroscopy measurements of radioisotopes from an IGISOL ion source
1997
Abstract The standard Doppler-free technique of collinear laser spectroscopy has been successfully applied to radioisotopes from the ion-guide isotope separator (IGISOL) at the University of Jyvaskyla. The laser resonance fluorescence signals for the 140,142,144 Ba radioisotopes show that the ion beam energy spread is less than 6 eV, allowing the laser technique to have both high resolution and a sensitivity comparable with the best obtained at conventional facilities.