Search results for "Guide"

Reply to the Letter Entitled "FeNO Variability when Using Different Analyzers at the Joint ATS/ERS Guideline Cutoff".

2019

S3-Leitlinie „Einsatz der intraaortalen Ballongegenpulsation in der Herzchirurgie“

2015

Although intra-aortic balloon pumping (IABP) is the most frequently used mechanical cardiac assist device in cardiothoracic surgery, there are only guidelines for substantive sections of aortic counterpulsation including prophylactic and postoperative use. In contrast, evidence-based recommendations are still lacking concerning intraoperative use, management, contraindication and other relevant issues. According to international surveys, important aspects of IABP usage show a wide variation in clinical practice. The results of a national questionnaire performed before initiation of this guideline confirmed these findings and demonstrated a clear need for the development of a consensus-based…

Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

2021

Background: To date, 750 000 patients with COVID-19 worldwide have required mechanical ventilation and thus are at high risk of acute brain dysfunction (coma and delirium). We aimed to investigate the prevalence of delirium and coma, and risk factors for delirium in critically ill patients with COVID-19, to aid the development of strategies to mitigate delirium and associated sequelae. Methods: This multicentre cohort study included 69 adult intensive care units (ICUs), across 14 countries. We included all patients (aged ≥18 years) admitted to participating ICUs with severe acute respiratory syndrome coronavirus 2 infection before April 28, 2020. Patients who were moribund or had life-suppo…

Severe asthma and COVID-19: lessons from the first wave

2020

Objective: Severe asthma is considered a risk factor for SARS-Coronavirus 2 (SARS-CoV-2) infection but scientific evidences are lacking. Methods: we performed a literature search and review based on PubMed database national, international recommendations as well as papers on severe asthmatic patients and their management during SARS-CoV-2 pandemic. Results: the majority of international recommendations, expert panels and editorials provide indications about management of severe asthmatic patients. No published studies evaluated the effects of biologic agents on severe asthmatic patients during SARS-CoV-2 pandemic. Conclusions: the relationship between SARS-CoV-2 and asthma is variable world…

[Clinical guidelines for the management of gastrointestinal stromal tumors]

2006

Treatment of gastrointestinal stromal tumors (GIST) has been revolutioned by the recently discovered molecular mechanism responsible for the oncogenesis of this disease. In addition, due to the rapid progress at molecular and clinical level observed in the last few years, there is a need to review the current state of the art in order to delineate appropriate guidelines for the optimal management of these tumors. A panel of experts from several specialities, including medical oncology, surgery, pathology, molecular biology and imaging, were invited to participate in a meeting to present and discuss a number of pre-selected questions, and to achieve a consensus according to the categories of…

Detection of batch effects in liquid chromatography-mass spectrometry metabolomic data using guided principal component analysis.

2014

Metabolomics based on liquid chromatography-mass spectrometry (LC-MS) is a powerful tool for studying dynamic responses of biological systems to different physiological or pathological conditions. Differences in the instrumental response within and between batches introduce unwanted and uncontrolled data variation that should be removed to extract useful information. This work exploits a recently developed method for the identification of batch effects in high throughput genomic data based on the calculation of a delta statistic through principal component analysis (PCA) and guided PCA. Its applicability to LC-MS metabolomic data was tested on two real examples. The first example involved t…

Are analysts doing method validation in liquid chromatography?

2014

International audience; Method validation is being applied in the reported analytical methods for decades. Even before this protocol was defined, authors already somehow validated their methods without full awareness. They wished to assure the quality of their work. Validation is an applied approach to verify that a method is suitable and rugged enough to function as a quality control tool in different locations and times. The performance parameters and statistical protocols followed throughout a validation study vary with the source of guidelines. Before single laboratory validation, an analytical method should be fully developed and optimized. The purpose of the validation is to confirm p…

The role of the reporting framework MIATA within current efforts to advance immune monitoring

2014

Exotic interactions mediated by a non-Hermitian photonic bath

2022

Photon-mediated interactions between quantum emitters in engineered photonic baths is an emerging area of quantum optics. At the same time, non-Hermitian (NH) physics is currently thriving, spurred by the exciting possibility to access new physics in systems ruled by non-trivial NH Hamiltonians - in particular photonic lattices - which can challenge longstanding tenets such as the Bloch theory of bands. Here, we combine these two fields and study the exotic interaction between emitters mediated by the photonic modes of a lossy photonic lattice described by a NH Hamiltonian. We show in a paradigmatic case study that structured losses in the field can seed exotic emission properties. Photons …

Exciting a Bound State in the Continuum through Multi-Photon Scattering plus Delayed Quantum Feedback

2019

Excitation of a bound state in the continuum (BIC) through scattering is problematic since it is by definition uncoupled. Here, we consider a type of dressed BIC and show that it can be excited in a nonlinear system through multi-photon scattering and delayed quantum feedback. The system is a semi-infinite waveguide with linear dispersion coupled to a qubit, in which a single-photon, dressed BIC is known to exist. We show that this BIC can be populated via multi-photon scattering in the non-Markovian regime, where the photon delay time (due to the qubit-mirror distance) is comparable with the qubit's decay. A similar process excites the BIC existing in an infinite waveguide coupled to two d…