Search results for "H.P.M."
showing 10 items of 738 documents
Off-Target-Based Design of Selective HIV-1 PROTEASE Inhibitors
2021
The approval of the first HIV-1 protease inhibitors (HIV-1 PRIs) marked a fundamental step in the control of AIDS, and this class of agents still represents the mainstay therapy for this illness. Despite the undisputed benefits, the necessary lifelong treatment led to numerous severe side-effects (metabolic syndrome, hepatotoxicity, diabetes, etc.). The HIV-1 PRIs are capable of interacting with “secondary” targets (off-targets) characterized by different biological activities from that of HIV-1 protease. In this scenario, the in-silico techniques undoubtedly contributed to the design of new small molecules with well-fitting selectivity against the main target, analyzing possible undesirabl…
Motivations for Business Start-up: Are There any Differences Between Disabled and Non-disabled Microfinance Clients?
2015
We use an Ecuadorian sample to investigate if there are differences in motivations for business start-up between persons with and without disabilities. Generally, we do not document significant differences. The reason might be that we use a sample selected among customers of the microfinance bank Banco D-MIRO. Without targeted incentives, disabled microfinance customers must resemble non-disabled customers. Copyright © 2015 John Wiley & Sons, Ltd.
The social networks of young people with intellectual disabilities during the On-Campus supported adult education programme
2016
<p>This article describes the social networks of four young people with intellectual disabilities in supported adult education, focusing on their inclusion in school and leisure environments. A multiple case study approach with content analysis was used. Data were collected through interviews with young people and their family members, relationship maps, observation journals and notes from Personal Futures Planning meetings. Relationships with family members, other relatives and neighbours were close. One participant had a friend of her own age with no disabilities. The other three had varying, superficial peer relationships and friends of the family. All the participants had heteroge…
Interfaith Dialogue in Christian Norway: Enactment of Inclusive Religiosity as Civilized Behavior
2017
Despite sparse scholarly attention from non-activists, Scandinavian interfaith fora are gaining momentum as a response to societal transformations of increased migration, world conflicts, and politically motivated violence. Combining theories of interaction, ritual performance, and civilizing processes, the article conducts a case study of public interfaith meetings held by a local interfaith forum in Kristiansand in Norway. Analyzing the meetings as organized cultural encounters, the study explores the transformative aspects of the events and it points to how the enactment of civilized forms of cross-cultural religiosity created within and by these public interfaith meetings is interlinked…
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a …
2022
Invasive mechanical ventilation; COVID-19; Critical care Ventilación mecánica invasiva; COVID-19; Cuidado crítico Ventilació mecànica invasiva; COVID-19; Atenció crítica Background Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods This is a multin…
Feasibility of a Responsibility-Based Leadership Training Program for Novice Physical Activity Instructors
2021
Most coaches and instructors would like to teach more than just sport skills to their athletes and children. However, to promote athletes' or children's holistic development and teach them to take responsibility and lead, requires the coaches and instructors to first master the skills themselves. Therefore, feasible, high quality leadership training programs where coaches and physical activity instructors are taught to teach and share leadership are needed. The aim of the current study was to evaluate the feasibility of a leadership training program to optimize it and to determine whether to proceed with its evaluation. In the leadership training program, eight Finnish novice physical activ…
Appetite for destruction: A psychometric examination and prevalence estimation of destructive leadership in Sweden
2021
There is a growing awareness that destructive leadership has a significant negative impact on employe outcomes. However, little is known about the content and dimensionality of this multidimensional concept, and there are few reliable measures available for organizations and researchers to evaluate these behaviors. Based on a representative sample (N = 1132) of the Swedish workforce, the aim of this study is threefold: first, to examine the factor structure and validity of an easy-to-use multidimensional destructive leadership measure (Destrudo-L)in the general Swedish work context; second, to identify destructive leadership profiles using latent profile analysis (LPA), and determine in wha…
The self-perceived commitment and relationship maintenance behaviors among Finnish-Chinese couples in Finland : an application of the investment mode…
2015
The investment model (2003) has been widely used in romantic relationship studies but rarely in an intercultural context. This study tests the investment model by examining Finnish-Chinese couples’ self-perceptions of commitment level and relationship maintenance behaviors. A qualitative research method with deductive thematic analysis approach is applied. This study finds that Finnish-Chinese couples have relatively high level of commitment. They tend to remain in their relationships, to actively derogate alternatives, to sacrifice self-welfare for gratifying relationship well-being, to perceive their relationships as good and healthy and to choose relationship constructive responses under…
Marketing communication in Finnish industrial companies
2010
Marketing communication has a significant role for profitable businesses in industrial markets, and its role is only expected to rise in the future. Especially, integrated marketing communication (IMC) and customer-oriented approach are universally regarded fundamental developments in the field of marketing. Secondly, Finnish companies’ marketing competences are commonly considered insufficient in general. The purpose of this study was to describe how Finnish industrial companies execute their marketing communication. In addition, the study examines the marketing communication’s strengths, weaknesses, opportunities, threats, and targets for development; how different marketing communication…
Follow‐up of patients subjected to direct and indirect pulp capping of young permanent teeth. A retrospective study
2021
Abstract Objective A retrospective study of the success rate of direct pulp capping (DPC) and indirect pulp capping (IPC) was carried out in children between 6–14 years‐old, considering separately primary caries or caries affecting teeth with molar incisor hypomineralization (MIH). Material and methods Data were collected in a dental public health service. Following the inclusion criteria, 232 treatments were analyzed. Success was defined by the presence of a functional tooth without clinical signs or symptoms of pulpal or periapical disease. The success rate was correlated to patient gender, the affected tooth and the indication of therapy using the chi‐squared and Fisher exact test. The s…