Search results for "H1"
showing 10 items of 1219 documents
Phenotypic and genetic characterization of emerging trematodiasis: Fascioliasis and Schistosomiasis
2021
La Fascioliasis y la Esquistosomiasis son dos importantes trematodiasis (re)emergentes con gran impacto en la salud humana. Dada la necesidad de caracterizar las poblaciones de Trematodos involucradas, los objetivos de la presente investigación son: en primer lugar, analizar el impacto de la reinfección experimental por Fasciola hepatica en los fenotipos inmunológicos, clínicos y biológicos por medio de un diseño experimental que reproduce las condiciones habituales de reinfección/cronicidad en las zonas endémicas de la Fascioliasis humana; en segundo lugar, la caracterización fenotípica morfológica de huevos de Schistosoma haematobium de migrantes subsaharianos con Esquistosomiasis urogeni…
Greater mitochondrial energy production provides resistance to ocean acidification in "winning" hermatypic corals
2021
Coral communities around the world are projected to be negatively affected by ocean acidification. Not all coral species will respond in the same manner to rising CO2 levels. Evidence from naturally acidified areas such as CO2 seeps have shown that although a few species are resistant to elevated CO2, most lack sufficient resistance resulting in their decline. This has led to the simple grouping of coral species into “winners” and “losers,” but the physiological traits supporting this ecological assessment are yet to be fully understood. Here using CO2 seeps, in two biogeographically distinct regions, we investigated whether physiological traits related to energy production [mitochondrial e…
Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis
2007
Abstract The transcription factor STAT4 mediates signals of various proinflammatory cytokines, such as IL-12, IL-15, and IL-23, that initiate and stabilize Th1 cytokine production. Although Th1 cytokine production has been suggested to play a major pathogenic role in rheumatoid arthritis, the role of STAT4 in this disease is poorly understood. In this study, we demonstrate a key functional role of STAT4 in murine collagen-induced arthritis (CIA). In initial studies we found that STAT4 expression is strongly induced in CD4+ T cells and to a lesser extent in CD11b+ APCs during CIA. To analyze the role of STAT4 for arthritis manifestation, we next investigated the outcome of interfering with S…
Pathogenesis of polymyalgia rheumatica
2018
Polymyalgia rheumatica (PMR) is a chronic, inflammatory disorder of unknown cause, almost exclusively occurring in people aged over 50 and often associated with giant cell arteritis. The evidence that PMR occurs almost exclusively in individuals aged over 50 may indicate that age-related immune alterations in genetically predisposed subjects contribute to development of the disease. Several infectious agents have been investigated as possible triggers of PMR even though the results are inconclusive. Activation of the innate and adaptive immune systems has been proved in PMR patients as demonstrated by the activation of dendritic cells and monocytes/macrophages and the altered balance betwee…
El periplo del objeto mitológico: itinerarios simbólicos del arte prehispánico entre los siglos XVI y XX
2014
Resumen : El presente texto discute la “identidad” que los objetos de arte prehispanico adquirieron desde el siglo XVI hasta mediados del siglo XX de acuerdo a los circuitos que recorrieron y los sujetos que los coleccionaron, miraron y pensaron. Itinerarios concretos: del contexto ritual al gabinete de curiosidades, del gabinete al museo arqueologico, del museo arqueologico a la muestra en espacios de arte. Itinerario que expresa las significaciones que el moderno Occidente les asigno en relacion a sus propias necesidades, anhelos y carencias. --------------------------- Abstract : This text discusses the "identity" that pre-Hispanic art objects acquired from the sixteenth to the twentieth…
Description and phylogenetic relationships of a new species of treefrog of theOsteocephalus buckleyispecies group (Anura: Hylidae)
2020
The Osteocephalus buckleyi species group is widely distributed in primary and secondary forests of the Amazon Basin and Guiana Region. Based on integrative analysis, including morphological and genetic data, we estimate the phylogenetic relationships and species boundaries among populations of the Osteocephalus buckleyi group from the Ecuadorian Amazon, focusing on the O. verruciger-O. cannatellai species complex. Our results uncovered the existence of one confirmed candidate species from Sangay National Park and one unconfirmed candidate species. Here, we describe the new species which is morphologically and ecologically distinct from other Osteocephalus species. The new species is unusual…
It takes time to see the menu from the body: an experiment on stable isotope composition in freshwater crayfishes
2015
For many applications and ecological studies in which wild individuals are brought to laboratory it would be essential to know accurately how fast novel diet is reflected in composition of different tissues. To study the effects of two different diets on the stable isotope composition of freshwater crayfish muscle and hemolymph, we conducted a three month experiment on noble crayfish (Astacus astacus) and signal crayfish (Pacifastacus leniusculus) by feeding them sweet corn (Zea mays) or Baltic herring (Clupea harengus membras) as novel food. During the experiment, the crayfish were given 0.4 g of selected food daily and the amount consumed was recorded. The samples for the stable isotope a…
Non-linear analysis of plane steel prestressed truss in fire
2002
The concept of analysis of 2-D static loaded prestressed steel trusses till failure during fire using a modified method of forces is presented. Failure of steel trusses in fire is based on the criterion of stresses. Behaviour of steel is described by non-linear constitutive model (based on hypo-elastic Ramberg-Osgood formula and Dorn creep theory) and Plem proposition (for string). Both models are approximated in calculations by hyperbolic Norton-Bailey rule. Fire simulates thermal force as an action of high temperature that increases linearly up to some level. The complete formulation of this method is illustrated by the algorithm of model parameters identification. Analysis of results for…
Comprehensive analysis of interacting proteins and genome-wide location studies of the Sas3-dependent NuA3 histone acetyltransferase complex
2014
Highlights • We characterise Sas3p and Gcn5p active HAT complexes in WT and deleted TAP-strains. • We confirm that Pdp3p interacts with NuA3, histones and chromatin regulators. • Pdp3p MS-analysis reveals its phosphorylation, ubiquitination and methylation. • Sas3p can substitute Gcn5p in acetylation of histone H3K14 but not of H3K9. • Genome-wide profiling of Sas3p supports its involvement in transcriptional elongation.
Maldivas y el delicado equilibrio entre India y China
2019
Maldivas es la nación más pequeña de Asia Meridional en términos de población, superficie y PBI. A pesar de ello, este pequeño archipiélago tiene una gran importancia estratégica, en virtud de su ubicación en medio de las rutas marítimas internacionales del océano Índico, y en su cercanía a las costas de la India. La propuesta de este artículo es exponer los cambios que se produjeron en Maldivas durante la presidencia de Abdulla Yameen en cuanto a la política interna, como así también a las relaciones exteriores, y observar en qué momento estas dos tendencias se cruzan para formar parte de una misma trama. A su vez, analizar finalmente las consecuencias que esto tiene para el país y para la…