Search results for "H1"
showing 10 items of 1219 documents
Deciphering the histone code to build the genome structure
2017
Histones are punctuated with small chemical modifications that alter their interaction with DNA. One attractive hypothesis stipulates that certain combinations of these histone modifications may function, alone or together, as a part of a predictive histone code to provide ground rules for chromatin folding. We consider four features that relate histone modifications to chromatin folding: charge neutralisation, molecular specificity, robustness and evolvability. Next, we present evidence for the association among different histone modifications at various levels of chromatin organisation and show how these relationships relate to function such as transcription, replication and cell division…
Histone Code and Higher-Order Chromatin Folding: A Hypothesis
2016
AbstractHistone modifications alone or in combination are thought to modulate chromatin structure and function; a concept termed histone code. By combining evidence from several studies, we investigated if the histone code can play a role in higher-order folding of chromatin. Firstly using genomic data, we analyzed associations between histone modifications at the nucleosome level. We could dissect the composition of individual nucleosomes into five predicted clusters of histone modifications. Secondly, by assembling the raw reads of histone modifications at various length scales, we noticed that the histone mark relationships that exist at nucleosome level tend to be maintained at the high…
Genotyping of a nosocomial outbreak of pandemic influenza A/H1N1 2009
2011
Background: Epidemiological surveys have revealed outbreaks of pandemic influenza A (H1N1) 2009 in several different contexts. Molecular characterization of the influenza virus could help to provide a more accurate description of these outbreaks. Objective: To genotype pandemic influenza A (H1N1) 2009 isolates from an epidemiologically defined nosocomial outbreak. Study design: We sequenced the neuraminidase (NA) and hemagglutinin (HA) influenza A (H1N1) 2009 genes from ten HIV-positive patients involved in an epidemiologically defined outbreak in the Clinical Microbiology and Infectious Diseases (CMID) Department. Sequences were aligned to search for specific genetic features of the involv…
Modelling the spatial-temporal progression of the 2009 A/H1N1 influenza pandemic in Chile
2016
A spatial-temporal transmission model of 2009 A/H1N1 pandemic influenza across Chile, a country that spans a large latitudinal range, is developed to characterize the spatial variation in peak timing of that pandemic as a function of local transmission rates, spatial connectivity assumptions for Chilean regions, and the putative location of introduction of the novel virus into the country. Specifically, a metapopulation SEIR (susceptible-exposed-infected-removed) compartmental model that tracks the transmission dynamics of influenza in 15 Chilean regions is calibrated. The model incorporates population mobility among neighboring regions and indirect mobility to and from other regions via th…
Reconfigurations in sustainability transitions : a systematic and critical review
2021
Two streams of literature have become especially prominent in understanding social change toward sustainability within the past decades: the research on socio-technical transitions and applications of social practice theory. The aim of this article is to contribute to efforts to create dialogue between these two approaches. We do this by focusing on the concept of reconfiguration, which has become a much-used, but poorly defined notion in the discussion on sustainability transitions. To understand what is defined as reconfiguration in systems and practices, and how the understanding of reconfiguration in regimes could benefit from insights about reconfiguration in practices, we conducted a …
Social representations of latin american immigrants about immigration, care and elderly caregivers
2013
Ageing in Spain has increased considerably and elderly people often find themselves in a situation of great dependence. Facing this situation, many have had the support of immigrant caregivers from Latin America. This research had the purpose to know the social representations (SR) of these caregivers, living in Valencia (Spain), about immigration, care and elderly care. It involved the participation of 35 immigrants who responded the Word Association Test and a socio-demographic questionnaire. The results revealed that the SR on immigration reflect "nostalgia", care was represented by "help", and care for the elderly by "respect". It is concluded that the SR allow understanding the symboli…
The closure of Nastola care home: A longitudinal study on deinstitutionalisation
2009
The Nastola Care Home, an institution housing 95 people with intellectual disability, was closed in 1989, with residents moving out into small community group homes of five people each. An intensive process of reorganization, including unitisation and staff training, occurred within the institution before its closure. The adaptive behaviour of 66 residents was measured a total of seven times, with the first phase beginning two and half years before the move, and the second phase extending to two years after the move. The results indicated an increase in adaptive skills of the residents in both phases. Challenging behaviour of the residents decreased before the move, but not afterwards. Comm…
Health Beliefs of Wearing Facemasks for Influenza A/H1N1 Prevention: A Qualitative Investigation of Hong Kong Older Adults.
2019
Although vaccination is the first-line strategy controlling and preventing influenza A/H1N1 for older adults, personal protective measures, such as wearing facemasks, are also important preventive behaviors to reduce the risk of becoming infected with influenza A/H1N1 during a pandemic. In the current study, we aimed to explore the belief-related psychological factors of wearing facemasks for influenza A/H1N1 prevention in a sample of Hong Kong older adults. Community-dwelling Chinese adults (N = 137) aged between 65 and 80 years (Mage = 75.10; SDage = 6.49) participated in semistructured interviews. Data were analyzed using theoretical thematic analysis and identified themes were matched …
Corrigendum: ILTER – The International Long-Term Ecological Research Network as a Platform for Global Coastal and Ocean Observation
2020
CORRECTION ARTICLEA Corrigendum on ILTER – The International Long-Term Ecological Research Network as a Platform for Global Coastal and Ocean Observation. doi: 10.3389/fmars.2019.00527
Shallow Sea Gas Manifestations in the Aegean Sea (Greece) as Natural Analogs to Study Ocean Acidification: First Catalog and Geochemical Characteriza…
2022
The concepts of CO2 emission, global warming, climate change, and their environmental impacts are of utmost importance for the understanding and protection of the ecosystems. Among the natural sources of gases into the atmosphere, the contribution of geogenic sources plays a crucial role. However, while subaerial emissions are widely studied, submarine outgassing is not yet well understood. In this study, we review and catalog 122 literature and unpublished data of submarine emissions distributed in ten coastal areas of the Aegean Sea. This catalog includes descriptions of the degassing vents through in situ observations, their chemical and isotopic compositions, and flux estimations. Tempe…