Search results for "H1"
showing 10 items of 1219 documents
Correction:Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrom…
2020
Lynch syndrome (LS) results from pathogenic variants in the mismatch repair (MMR) genes and is the most common hereditary cancer syndrome, affecting an estimated 1 in 300 individuals. Pathogenic variants in each of the MMR genes path_MLH1, path_MSH2, path_MSH6, and path_PMS2 result in different risks for cancers in organs including the colorectum, endometrium, ovaries, stomach, small bowel, bile duct, pancreas, and upper urinary tract. Accurate estimates of these risks are essential for planning appropriate approaches to the prevention or early diagnosis of cancers but the robustness of previous studies has been limited by factors including retrospective design,1,2 lack of validation in ind…
Programmed Death Ligand 1 (PD-L1) as a Predictive Biomarker for Pembrolizumab Therapy in Patients with Advanced Non-Small-Cell Lung Cancer (NSCLC).
2019
Recently, immunotherapy has been shown to be an effective and helpful therapeutic option for the treatment of advanced non-small-cell lung cancer (NSCLC). The activity of antitumor T cells may be restored through the checkpoint blockade using anti-programmed death 1 or anti-programmed death ligand 1 (PD-L1) antibodies, showing, in several cancer patients, an increased progression-free survival and overall survival compared with classical chemotherapy. As recently shown by several studies, the PD-L1 expression levels in tumors may offer a selection criterion for patients to predict their immunotherapy response. In particular, NSCLC patients with high tumor PD-L1 levels (proportional score ≥ …
Immune cell score, PD-L1 expression and prognosis in esophageal cancer.
2021
Esophageal cancer (EC) is the ninth most common cancer worldwide and the sixth leading cause of cancer death [1]. Despite improvements in the treatment of EC, the general outcome remains poor [2–4]...
Characterization of PD-1 and PD-L1 Expression in Papillary Renal Cell Carcinoma: Results of a Large Multicenter Study
2021
Abstract Background Programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) play a decisive role as prognostic markers in clear-cell renal cell carcinoma (RCC). To date, the role of PD-1/PD-L1 as a prognostic marker in papillary RCC (pRCC) remains scarce. Patients and Methods Patients’ sample collection was a joint collaboration of the nationwide PANZAR consortium – a multicenter study. Medical history and tumor specimens were collected from 245 and 129 patients with pRCC types 1 and 2, respectively. Expression of PD-1 and PD-L1 was determined by immunohistochemistry in pRCC and tumor-infiltrating mononuclear cells. Results Of 374 pRCC specimens, 204 type 1 and 97 type 2 we…
Hereditary ovarian cancer.
2008
Apoptosis is a form of cell death that permits the removal of damaged, senescent or unwanted cells in multicellular organisms, without damage to the cellular microenvironment. Defective apoptosis represents a major causative factor in the development and progression of cancer. The majority of chemotherapeutic agents, as well as radiation, utilize the apoptotic pathway to induce cancer cell death. Resistance to standard chemotherapeutic strategies also seems to be due to alterations in the apoptotic pathway of cancer cells. Recent knowledge on apoptosis has provided the basis for novel targeted therapies that exploit apoptosis to treat cancer. These new target include those acting in the ext…
Oral mucositis. Is it present in the immunotherapy of the immune checkpoint pd1/pd-l1 against oral cancer? A systematic review
2020
Background Oral mucositis (OM) is a painful lesion that takes place in the mucosa of the oral cavity, usually its etiology is associated with drug therapies in cancer patients. It is presented as well-defined ulcers whose painful symptomatology sometimes implies the suspension of oncological treatment or parenteral feeding, being therefore an important adverse effect, marking the evolution of these types of therapies against cancer. The present work aim is to know the prevalence of oral mucositis in oral cancer immunotherapy compared to its prevalence in standard therapy. Material and Methods A protocol was developed for a systematic review following PRISMA® guidelines and a focused questio…
From Planning to Management of Cultural Heritage Sites: Controversies and Conflicts Between Unesco WHL Management Plans and Local Spatial Planning in…
2014
The paper investigates the relationship between the preservation of cultural heritage and planning in UNESCO World Heritage List (WHL) sites, with special reference to the relation be- tween Management Plans and other (local and regional) planning instruments and policies able to influence the promotion of sustainable and responsible development. This will be explored through a case study related to South-Eastern Sicilian UNESCO sites (in particular Syracuse). The analysis of this case study will point out the challenge of integrating different management and planning regimes - which mainly refer to a performative model - in a (still) very conformative planning sys- tem. The paper will show…
Foucault and deaf education in Finland
2016
The influence of Michel Foucault’s thinking in critical disability studies, and to social studies of deafness, can hardly be doubted. Foucault has offered valuable tools for the critical rethinking of deaf education and pedagogy with respect to normalization and disciplinary power, which are integrally related to the historical construction of deafness as deficiency and pathology by modern, medical, and psychological knowledge. This article explores the applicability and critical potential of the Foucauldian concepts of disciplinary power, surveillance, and normalization within the specific context of the history of deaf education in Finland. The article focuses on the modernization of the …
Travelling with Darwin and Humboldt. A Transdisciplinary Educational Experience
2019
Aim. This research aims to confirm that transdisciplinary projects can be very adequate to develop content and competencies traditionally assigned to Sciences and Arts in higher education, exploring the possibilities of outdoor education.
 Methods. The subjects of the study were one hundred alumni of two different courses “Natural Sciences for Teachers” and “Literary Training for Teachers” at a Spanish university. An educational experience around the phenomenon of scientific travelers was developed, focusing on Charles Darwin and Alexander von Humboldt and the literary genres of travel journals and letters. The main activity contained three phases, including indoor and outdoor educatio…
Numerical Analysis of Bearing Capacity of a Ring Footing on Geogrid Reinforced Sand
2021
A ring footing is found to be of practical importance in supporting symmetrical constructions for example silos, oil storage container etc. In the present paper, numerical analysis was carried out with explicit code FLAC3D 7.0 to investigate bearing capacity of a ring footing on geogrid reinforced sand. Effects of the ratio n of its inner/outer diameter (Di/D) of a ring footing, an optimum depth to lay the geogrid layer were examined. It was found that an intersection zone was developed in soil under inner-side (aisle) of ring footing, contributing to its bearing capacity. Substantial increase of bearing capacities could be realized if ratio n of a ring footing was around 0.6. Numerical res…