Search results for "H1"
showing 10 items of 1219 documents
Housing Affordability in Metropolitan Areas. The Application of a Combination of the Ratio Income and Residual Income Approaches to Two Case Studies …
2017
Housing affordability problems have become more serious over the course of the last few decades and are now also affecting the middle-class, despite the fall in prices on the housing market. This study proposes a methodology to assess threshold-income as an index for measuring housing affordability by applying a combination of the ratio income and residual income approaches. The methodology is applied to two particular areas of Sicily in Italy as case studies consisting of medium-size metropolitan areas located in a less developed European region. The areas have been chosen on the basis of their different territorial structure: a polarized area that comprises a high-density city centre and …
Study of USH1 Splicing Variants through Minigenes and Transcript Analysis from Nasal Epithelial Cells
2012
Usher syndrome type I (USH1) is an autosomal recessive disorder characterized by congenital profound deafness, vestibular areflexia and prepubertal retinitis pigmentosa. The first purpose of this study was to determine the pathologic nature of eighteen USH1 putative splicing variants found in our series and their effect in the splicing process by minigene assays. These variants were selected according to bioinformatic analysis. The second aim was to analyze the USH1 transcripts, obtained from nasal epithelial cells samples of our patients, in order to corroborate the observed effect of mutations by minigenes in patient’s tissues. The last objective was to evaluate the nasal ciliary beat fre…
Human Papilloma Virus-Dependent HMGA1 Expression Is a Relevant Step in Cervical Carcinogenesis
2008
HMGA1 is a member of a small family of architectural transcription factors involved in the coordinate assembly of multiprotein complexes referred to as enhanceosomes. In addition to their role in cell proliferation, differentiation, and development, high-mobility group proteins of the A type (HMGA) family members behave as transforming protoncogenes either in vitro or in animal models. Recent reports indicated that HMGA1 might counteract p53 pathway and provided an interesting hint on the mechanisms determining HMGA's transforming potential. HMGA1 expression is deregulated in a very large array of human tumors, including cervical cancer, but very limited information is available on the mole…
How technology-based firms become also highly innovative firms? The role of knowledge, technological and managerial capabilities, and entrepreneurs’ …
2019
To what extent is the likelihood that a Technology-Based Firm – TBF – turns into a Technology-Based and Highly Innovative Firm – TB&InnF – is influenced by technical capabilities or managerial capabilities and education background? We analyse this question using a novel data panel assembled for 326 Spanish industrial firms, along the period 1998–2014. Our findings show the probability of becoming a TB&InnF growths when firms are able to accumulate a high endowment of knowledge and technological capabilities, and a managerial team with experience, a strong power position and previous technical or managerial education background. Results also indicate the CEO's educational profile in manageme…
Actitudes religiosas, Valores y Razonamiento Moral Prosocial en una muestra adolescente
2017
Objetivo: estudiar la relación existente entre la religiosidad, los valores y el razonamiento moral prosocial de estudiantes de secundaria. La primera hipótesis que se pretende comprobar es si la religiosidad es capaz de predecir algún tipo específico de razonamiento moral prosocial (RMP). La segunda hipótesis trata de investigar si la religiosidad está relacionada con los valores de la escala de Rockeach. Metodología: la muestra utilizada está compuesta por 421 adolescentes de entre 13 y 18 años. Se han llevado a cabo modelos de regresión múltiple y pruebas MANOVA. Resultados: según los modelos de regresión múltiple, se concluyó que los estudiantes que dan menos importancia a Dios en sus v…
Reseña de Agulló Albuixech, Agulló Calatayud y Fuertes (2014). La vida cotidiana en Siete Aguas desde Cavanilles hasta el Gran Fondo (1795-1985)
2014
En las Ciencias Sociales el estudio de la vida cotidiana es relativamente reciente y surge del interés por sacar a la luz lo que muchas veces queda oculto. Lo que va pasando mientras parece que no pasa nada. Con una pretensión que aúna lo divulgativo y lo académico, los autores recorren en este libro los más diversos aspectos que configuran la rica vida cotidiana de una localidad rural valenciana, Siete Aguas.
Retention pharmacokinetic and pharmacodynamic parameter relationships of antihistamine drugs using biopartitioning micellar chromatography
2001
Abstract Antihistamines are drugs which act by competitive inhibition of the H1 or H2 histamine receptors. Little has been known about their clinical pharmacokinetics and biological responses until the last few years. In this paper, we propose quantitative retention–activity relationship, QRAR, models based on the retention data of antihistamines in a biopartitioning micellar chromatography (BMC) system using a Brij35 mobile phase for describing pharmacokinetic parameters such as half-life and volume of distribution, or the pharmacodynamic parameters, therapeutic plasma levels, lethal doses and drug-receptor dissociation constant. The predictive ability of these models is statistically vali…
Integración de restos arqueológicos Almohades en el metropolitano de Granada. La investigación multidisciplinar para el proyecto y desarrollo de infr…
2014
The execution of the Granada Metropolitan’s underground line made possible the discovery of archeological remains of a water tank in Alcázar Genil, a royal muslim residence of the 13th century. The water tank, 419 × 88 ft, was destroyed at its ends due to the growth of the city of Granada during the 20th century and today remains only its center section, under Camino de Ronda, exactly where the future Metropolitan will take place. The location of an underground station will allow the recovery, the integration and the exhibition of the archaeological remains of this water tank. The Alcázar Genil station project brings together the work of several disciplines which put in the same level engin…
Psychological Contract Violation or Basic Need Frustration? Psychological Mechanisms Behind the Effects of Workplace Bullying
2021
Workplace bullying is a phenomenon that can have serious detrimental effects on health, work-related attitudes, and the behavior of the target. Particularly, workplace bullying exposure has been linked to lower level of general well-being, job satisfaction, vigor, and performance and higher level of burnout, workplace deviance, and turnover intentions. However, the psychological mechanisms behind these relations are still not well-understood. Drawing on psychological contract and self-determination theory (SDT), we hypothesized that perceptions of contract violation and the frustration of basic needs mediate the relationship between workplace bullying exposure and well-being, attitudinal, a…
Orígenes de las movilizaciones #primaveravalenciana : un análisis de los actores sociales más influyentes en Twitter
2018
Los públicos de Twitter se han convertido en un objeto de investigación social claramente consolidado. El objetivo del trabajo es contribuir a esta corriente de investigación con el análisis de las condiciones sociales que favorecieron la expansión de la etiqueta #primaveravalenciana. Para ello, nos centraremos en la etapa inicial de la etiqueta, estableciendo una tipología de participantes, identificando a los actores más influyentes y realizando un análisis de contenido de los micro-mensajes que fomentaron la expansión viral de la etiqueta en los días posteriores. Frente a las teorías que tienden a minimizar las distinciones sociales en las interacciones de las redes sociales, el análisis…