Search results for "HALA"
showing 10 items of 1485 documents
Hypothalamic-Pituitary-Adrenal axis and cognitive function in healthy older people: genetic, situational and individual factors
2019
The world population is getting older, and this age group faces important health challenges, among which age-related cognitive decline stands out. Therefore, it is important to identify vulnerability and protective health factors in order to understand ways to prevent cognitive decline. This thesis aimed to address the relationship between the Hypothalamic–Pituitary–Adrenal (HPA) axis and cognitive functioning during aging, taking into account genetic (Apolipoprotein E, ApoE, polymorphism), situational (loneliness), and individual factors (personality traits). To do this, a group of healthy older people over 55 years of age, men and women, were evaluated. A neuropsychological battery was ad…
Składniki tworzyw sztucznych zaburzające funkcje układu nerwowego
2013
Rozwój przemysłu chemicznego spowodował opracowywanie nowych związków chemicznych niewystępujących w środowisku naturalnym. Substancje te spełniają różnorodne funkcje, takie jak obniżenie palności, zwiększenie plastyczności czy poprawienie rozpuszczalności innych substancji. Wiele związków wchodzących w skład tworzyw sztucznych, kosmetyków nowej generacji, aparatury medycznej, opakowań spożywczych oraz innych produktów codziennego użytku, z łatwością uwalniają się do środowiska naturalnego. Liczne badania wykazały, że substancje, takie jak: ftalany, BPA, TBBPA oraz PCB charakteryzują się znaczną lipofilnością dzięki czemu w łatwy sposób wnikają do żywych komórek oraz akumulują się w tkankac…
Analytical Method for Quantification of Several Phthalate Acid Esters by Gas Chromatography-Mass Spectrometry in Coffee Brew Samples
2022
Several phthalate acid esters (PAEs), often called phthalate esters or phthalates, are substances classified as harmful due to their carcinogenic and mutagenic properties, and moreover, as dangerous for humans because they interfere with the endocrine system. In general, phthalic esters are used as plasticizers for different polymers and more other consumer products. In the present study, we describe a simple method to quantify PAEs in coffee brew using a liquid-liquid extraction without purification processes through analysing the obtained organic phase by GCMS in the single ion monitoring mode. The totals of single PAEs, in coffee brew samples analysed by us, are in the range of 159-5305 …
Realization of polyaspartamide-based nanoparticles and in vivo lung biodistribution evaluation of a loaded gucocorticoid after aerosolization in mice
2016
Abstract In this study, novel polymeric nanoparticles (NPs) were developed and their potential as carriers for beclomethasone dipropionate (BDP) into the lung after aerosolization was demonstrated by in vivo studies in mice. In particular, these NPs were obtained starting from two polyaspartamide-based copolymers which were synthesized by chemical reaction of α,β-poly(N-2-hydroxyethyl)- dl -aspartamide (PHEA) and its pegylated derivative (PHEA-PEG2000) with poly(lactic acid) (PLA). To obtain nanosized particles, the high pressure homogenization (HPH)—solvent evaporation method was followed by using an organic phase containing both PHEA-PLA and PHEA-PEG2000-PLA (at a weight ratio equal to 1:…
Tirer et porter : l’emploi des bovins au Néolithique. Apport de l’étude des phalanges 1
2011
International audience; Tirer et porter : l’emploi des bovins au Néolithique. Apport de l’étude des phalanges 1
Coste-efectividad de la suspensión del tratamiento con colistina inhalada en los pacientes con bronquiectasias del adulto no debidas a fibrosis quíst…
2018
Introducción Las bronquiectasias no debidas a fibrosis quística son, en frecuencia, la tercera enfermedad inflamatoria crónica de la vía aérea, después del asma y de la enfermedad pulmonar obstructiva crónica, y están en estrecha relación con ambas. El número de casos diagnosticados va en aumento cada día, sobre todo debido a la longevidad creciente de la población y al uso generalizado de las técnicas de imagen que confirman su diagnóstico como la tomografía axial computarizada de alta resolución. Las bronquiectasias son una causa clara de morbimortalidad y suponen una importante carga económica. Los pacientes afectos de bronquiectasias suelen tener exacerbaciones infecciosas que requieren…
Petäjävesi
Efficacy of Rapamycin as Inducer of Hb F in Primary Erythroid Cultures from Sickle Cell Disease and β-Thalassemia Patients.
2015
Phenotypic improvement of hemoglobinopathies such as sickle cell disease and β-thalassemia (β-thal) has been shown in patients with high levels of Hb F. Among the drugs proposed to increase Hb F production, hydroxyurea (HU) is currently the only one proven to improve the clinical course of these diseases. However, Hb F increase and patient's response are highly variable, indicating that new pharmacological agents could be useful for patients not responding to HU or showing a reduction of response during long-term therapy. In this study we evaluated the efficacy of rapamycin, a lypophilic macrolide used for the prevention of acute rejection in renal transplant recipients, as an inducer of Hb…