Search results for "HAP"

Stereocontrolled synthesis of fluorine-containing piperidine γ-amino acid derivatives

2019

An efficient synthetic approach for the construction of fluorine‐containing piperidine γ‐amino acid derivatives has been developed. The synthetic concept was based on oxidative ring opening of an unsaturated bicyclic γ‐lactam (Vince‐lactam) through its ring C=C bond, followed by double reductive amination of the diformyl intermediate performed with various fluoroalkylamines. The method has been extended towards the access of alkylated and perfluoroalkylated substances and for γ‐lactam derivatives. The transformations proceeded with stereocontrol: the configuration of the stereocenters in the products were predetermined by the configuration of the chiral centers of the starting γ‐lactam. The…

The Influence of Nanoparticle Shape on Protein Corona Formation

2020

Nanoparticles have become an important utility in many areas of medical treatment such as targeted drug and treatment delivery as well as imaging and diagnostics. These advances require a complete understanding of nanoparticles' fate once placed in the body. Upon exposure to blood, proteins adsorb onto the nanoparticles surface and form a protein corona, which determines the particles' biological fate. This study reports on the protein corona formation from blood serum and plasma on spherical and rod‐shaped nanoparticles. These two types of mesoporous silica nanoparticles have identical chemistry, porosity, surface potential, and size in the y ‐dimension, one being a sphere and the other a …

Bisfosfonaatit : valmistus, ominaisuudet ja lääketieteellinen käyttö

2016

Tutkielman kirjallisessa osassa perehdytään bisfosfonaatteihin, niiden ominaisuuksiin ja valmistukseen sekä käyttöön lääketieteessä. Bisfosfonaattien valmistuksessa perehdytään sekä itse bisfosfonaattien että niiden johdannaisten valmistukseen. Bisfosfonaattien ominaisuuksia käydään läpi esittämällä niiden kemiallisia, biokemiallisia sekä farmakologisia ominaisuuksia ja vaikutustapoja. Eri bisfosfonaattien ominaisuuksia käsittelevät kappaleet on jaoteltu niistä käytettävän sukupolvijaottelun mukaisesti. Bisfosfonaattien käytössä pääosassa ovat niiden lääketieteelliset sovellukset. Bisfosfonaattien aihiolääkkeiden valmistuksessa keskitytään happoryhmän esteröintiin, amino- tai hydroksyyliryh…

Sapņu dienasgrāmata

2016

Tīmekļa lietotne “Sapņu dienasgrāmata” ļauj lietotājiem dokumentēt sapņu un dienas notikumus (ierakstus) privātās digitālās dienasgrāmatas veidā savstarpējai analīzei, kā arī sevis analizēšanai. Lietotne ļauj lietotājam formulēt savienojumus starp dienas un sapņu ierakstiem, kuri ir pašanalīzes rezultāti. Mērķis ir piedāvāt objektīvu rīku sevis analīzei caur sapņiem, nebalstoties uz psihoanalīzes skolām, t.i., necensties pateikt lietotājam kā analizēt sapņus. Projekta izstrāde notiek ar spējās (Agile) izstrādes pieeju, regulāri paplašinot un izstrādājot funkcionalitāti, balstoties uz regulārām SCRUM tikšanām. Sistēma tiek realizēta server puses javaskriptā (Node.js) hapi.js ietvarā, balstot…

Trait Hedonism and the Distribution of Savoring and Positive Emotion States in Everyday Life.

2022

International audience; The present study aimed at (1) identifying the emotion regulation processes that can explain the trait hedonism positive emotions relationship, and (2) determining whether this relationship varies according to which part of the distribution of positive emotions is considered. To this end, the intensity of the positive emotions felt by 84 adult participants, and the intensity of their engagement in savoring, were assessed twice a day over a month period, using an Experience Sampling Method. Participants’ distributions of these variables were then related to their level of trait hedonism, assessed with a common questionnaire. Results suggested that, as expected, the tr…

Experimental analysis of transverse flow motion in a large amplitude meandering bend

2008

Separation of palladium and silver from E-waste leachate : effect of nitric acid concentration on adsorption to Thiol scavenger

2022

The development of recovery techniques for metals present in low concentrations in E-waste, such as silver and palladium, is important from the aspect of the circular economy. Adsorption of palladium and silver was studied in detail in a batch process with silica-based Thiol scavenger from nitric acid leachate of waste printed circuit boards (PCBs). High adsorption efficiencies of Pd(II) and Ag(I), >97%, were reached in nitric acid concentrations below 3 mol L−1. At higher acid concentrations, adsorption efficiency of Ag(I) decreased drastically which enables the separation of Ag(I) and Pd(II) based on nitric acid concentration in sample solution. Pd(II) and Ag(I) followed pseudo 2nd order …

Spectrum-shape method and the next-to-leading-order terms of the β-decay shape factor

2017

Effective values of the axial-vector coupling constant gA have lately attracted much attention due to the prominent role of gA in determining the half-lives of double β decays, in particular their neutrinoless mode. The half-life method, i.e., comparing the calculated half-lives to the corresponding experimental ones, is the most widely used method to access the effective values of gA. The present paper investigates the possibilities offered by a complementary method: the spectrum-shape method (SSM). In the SSM, comparison of the shapes of the calculated and measured β electron spectra of forbidden nonunique β decays yields information on the magnitude of gA. In parallel, we investigate the…

Shape identification in inverse medium scattering problems with a single far-field pattern

2016

Consider time-harmonic acoustic scattering from a bounded penetrable obstacle $D\subset {\mathbb R}^N$ embedded in a homogeneous background medium. The index of refraction characterizing the material inside $D$ is supposed to be Holder continuous near the corners. If $D\subset {\mathbb R}^2$ is a convex polygon, we prove that its shape and location can be uniquely determined by the far-field pattern incited by a single incident wave at a fixed frequency. In dimensions $N \geq 3$, the uniqueness applies to penetrable scatterers of rectangular type with additional assumptions on the smoothness of the contrast. Our arguments are motivated by recent studies on the absence of nonscattering waven…

Multi-Chip RFID Antenna Integrating Shape-Memory Alloys for Detection of Thermal Thresholds

2011

Low-cost wireless measurement of objects' temperature is one of the greatest expectation of radiofrequency identification technology for the so many applications in cold supply-chain control and safety assessment in general. In this context, the paper proposes a dual-chip UHF tag embedding shape memory alloys (SMA) able to transform the variation of the tagged item's temperature into a permanent change of antenna radiation features. This event-driven antenna is hence able to selectively activate the embedded microchips according to the temperature above or below a given threshold. A general design methodology for the resulting two-ports tag antenna is here introduced and then applied to pro…