Search results for "HAp"

Response to Comment on "Ancient DNA from the First European Farmers in 7500-Year-Old Neolithic Sites"

2006

The discovery of mitochondrial type N1a in Central European Neolithic skeletons at a high frequency enabled us to answer the question of whether the modern population is maternally descended from the early farmers instead of addressing the traditional question of the origin of early European farmers.

Emotion recognition changes in a confinement situation due to COVID-19

2020

Abstract The confinement situation experienced as a result of COVID-19 will have consequences at a psychological level. These consequences can affect emotion recognition because, due to isolation, interactions and social contacts have been drastically reduced. The aim of this study was to find out if there were differences in facial emotion recognition in two groups of young adults, one confined during COVID-19 and the other unconfined. One hundred and sixty-four young adults were tested twice, the first time unconfined, to obtain the baseline, then the sample was divided into two subgroups so that 84 were evaluated in a confined situation and 80 in an unconfined situation. . Ekman 60 Faces…

Acute incremental endurance performance and explosive strength training period : muscle activity, acid-base balance and hormonal responses

2015

Johdanto. Akuutin kestävyys- ja voimaharjoituksen fysiologiset vasteet ilmenevät luurankolihaksissa, hengitys- ja verenkiertoelimistössä, sekä endokriinisessa että immuunijärjestelmässä. Nämä vasteet voivat heikentää suorituskykyä, ja esimerkiksi happo-emästasapaino on tarkoin säädelty negatiivisten seurausten varalta. Lihasten toimintaa voidaan tutkia elektromyografialla (EMG), ja nykyään on myös mahdollista käyttää tekstiilielektrodeja, jotka mahdollistavat lihasryhmien sähköisen aktiivisuuden tallentamisen normaalin liikkumisen aikana. Tämän tutkimuksen tarkoituksena oli tutkia yhteyksiä etu- ja takareisien lihasaktiivisuuksien ja happo-emästasapainon välillä, vertailla lihasaktiivisuuks…

Multiobjective muffler shape optimization with hybrid acoustics modelling

2010

Shape optimization of a duct system with respect to sound transmission loss is considered. The objective of optimization is to maximize the sound transmission loss at multiple frequency ranges simultaneously by adjusting the shape of a reactive muffler component. The noise reduction problem is formulated as a multiobjective optimization problem. The sound attenuation for each considered frequency is determined by a hybrid method, which requires solving Helmholtz equation numerically by finite element method. The optimization is performed using non-dominated sorting genetic algorithm, NSGA-II, which is a multi-objective genetic algorithm. The hybrid numerical method is flexible with respect …

Äänenvaimentimien mallinnuspohjainen monitavotteinen muodonoptimointi

2011

Multiobjective muffler shape optimization with hybrid acoustics modelling

2011

This paper considers the combined use of a hybrid numerical method for the modeling of acoustic mufflers and a genetic algorithm for multiobjective optimization. The hybrid numerical method provides accurate modeling of sound propagation in uniform waveguides with non-uniform obstructions. It is based on coupling a wave based modal solution in the uniform sections of the waveguide to a finite element solution in the non-uniform component. Finite element method provides flexible modeling of complicated geometries, varying material parameters, and boundary conditions, while the wave based solution leads to accurate treatment of non-reflecting boundaries and straightforward computation of the …

Event-shape engineering for inclusive spectra and elliptic flow in Pb-Pb collisions at √sNN = 2.76 TeV

2016

We report on results obtained with the event-shape engineering technique applied to Pb-Pb collisions at √sNN = 2.76 TeV. By selecting events in the same centrality interval, but with very different average flow, different initial-state conditions can be studied. We find the effect of the event-shape selection on the elliptic flow coefficient v2 to be almost independent of transverse momentum pT, which is as expected if this effect is attributable to fluctuations in the initial geometry of the system. Charged-hadron, -pion, -kaon, and -proton transverse momentum distributions are found to be harder in events with higher-than-average elliptic flow, indicating an interplay between radial and e…

Higher plants possess two different types of ATX1-like copper chaperones.

2007

Abstract Copper (Cu) chaperones constitute a family of small Cu+-binding proteins required for Cu homeostasis in eukaryotes. The ATX1 family of Cu chaperones specifically delivers Cu to heavy metal P-type ATPases. The plant Arabidopsis thaliana expresses the ATX1-like Cu chaperone CCH, which exhibits a plant-specific carboxy-terminal domain (CTD) with unique structural properties. We show that CCH homologues from other higher plants contain CTDs with structural properties similar to Arabidopsis CCH. Furthermore, we identify a new ATX1-like Cu chaperone in Arabidopsis, AtATX1, which functionally complements yeast atx1Δ and sod1Δ associated phenotypes, and localizes to the cytosol of Arabidop…

Extracellular heat shock proteins in cancer: From early diagnosis to new therapeutic approach

2021

In cancer, human cells lose the ability to properly control the series of events that occur constantly during cell growth and division, including protein expression, stability, and dynamics. Heat shock proteins (Hsps) are key molecules in these events, constitutively expressed at high levels and could furthermore be induced by the response to cancer-induced stress. In tumor cells, Hsps have been shown to be implicated in the regulation of apoptosis, immune responses, angiogenesis and metastasis; in some cases, they can be overexpressed and dysregulated, representing important cancer hallmarks. In the past few years, it has been demonstrated that Hsps can be released by tumor cells through s…

Functional and conformational properties of the exclusive C-domain from the Arabidopsis copper chaperone (CCH)

2001

The Arabidopsis thaliana copper chaperone (CCH) is a small copper binding protein involved in copper trafficking. When compared to homologues from other eukaryotes, CCH has two different domains; the conserved N-domain and the plant-exclusive C-domain, a C-terminal extension with an unusual amino-acid composition. In order to characterize this extra C-domain, the CCH protein, the N-domain and the C-domain were all expressed separately in heterologous systems. While the N-domain retained the copper chaperone and antioxidant properties described for the yeast Atx1 and human HAH1 counterparts, the C-domain displayed particular structural properties that would be necessary to optimize copper ho…