Search results for "HAp"
showing 10 items of 2767 documents
An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease.
2011
This paper addresses a tenet of the literature on APOE, i.e., the relationship between the effects of the e4, one of the established genetic risk factor for Alzheimer's disease (AD), and its expression levels as determined by APOE promoter polymorphisms. Five polymorphisms (-491 rs449647, -427 rs769446, -219 rs405509, and e rs429358-rs7412) were studied in 1308 AD patients and 1082 control individuals from the Central-Northern Italy. Major findings of the present study are the following: 1) the variants -219T and e4 increase the risk for late onset AD (LOAD) when they are both present in cis on the same chromosome (in phase); 2) the correlation between the haplotype (-219T/e4) and AD risk p…
Haptoglobin interacts with apolipoprotein E and beta-amyloid and influences their crosstalk.
2014
Beta-amyloid accumulation in brain is a driving force for Alzheimer's disease pathogenesis. Apolipoprotein E (ApoE) represents a critical player in beta-amyloid homeostasis, but its role in disease progression is controversial. We previously reported that the acute-phase protein haptoglobin binds ApoE and impairs its function in cholesterol homeostasis. The major aims of this study were to characterize the binding of haptoglobin to beta-amyloid, and to evaluate whether haptoglobin affects ApoE binding to beta-amyloid. Haptoglobin is here reported to form a complex with beta-amyloid as shown by immunoblotting experiments with purified proteins, or by its immunoprecipitation in brain tissues …
Two Italian kindreds carrying the Arg136--Ser mutation of the Apo E gene: development of premature and severe atherosclerosis in the presence of epsi…
2003
Abstract Background and Aims: Type III hyperlipoproteinemia, or dysbetalipoproteinemia, is commonly associated with apolipoprotein E2 homozygosity (Cy Background and Aims: 12, Cy Background and Aims: 58). Apo E2-Christchurch (Arg136→Ser), a rare mutation of the Apo E gene, located in the receptor-binding domain of the protein, has been found to be associated in the vast majority of cases of dysbetalipoproteinemia. Methods and Results: This is the first report of two Italian kindreds carrying the Arg136→Ser mutation. One family is a four-generation kindred from Genoa (Liguria, Italy) with a high rate of mortality due to coronary artery disease: the proband was a 51-year-old woman with previo…
Lack of Dystrophin Affects Bronchial Epithelium in mdx Mice
2016
Mild exercise training may positively affect the course of Duchenne Muscular Dystrophy (DMD). Training causes mild bronchial epithelial injury in both humans and mice, but no study assessed the effects of exercise in mdx mice, a well known model of DMD. The airway epithelium was examined in mdx (C57BL/10ScSn-Dmdmdx) mice, and in wild type (WT, C57BL/10ScSc) mice either under sedentary conditions (mdx-SD, WT-SD) or during mild exercise training (mdx-EX, WT-EX). At baseline, and after 30 and 45 days of training (5 d/wk for 6 weeks), epithelial morphology and markers of regeneration, apoptosis, and cellular stress were assessed. The number of goblet cells in bronchial epithelium was much lower…
Wulff shape characterizations in overdetermined anisotropic elliptic problems
2017
We study some overdetermined problems for possibly anisotropic degenerate elliptic PDEs, including the well-known Serrin's overdetermined problem, and we prove the corresponding Wulff shape characterizations by using some integral identities and just one pointwise inequality. Our techniques provide a somehow unified approach to this variety of problems.
La medición de la felicidad en el trabajo y sus antecedentes : un estudio empírico en el area de alergología de los hospitales públicos españoles
2014
La búsqueda de la felicidad en el trabajo es un objetivo de enorme importancia para muchas personas y organizaciones. Sin embargo, existe una carencia importante la investigación acerca de cómo aumentarla (Chivato Pérez et al., 2011), así como una amplia dispersión de medidas relacionadas (Hackman, 2009). No se conoce ninguna medida que recoja con la suficiente amplitud la medición de la felicidad en el trabajo (Fisher, 2010), por lo que en este estudio proponemos un modelo integrativo que nos aporte la medida de este nuevo constructo. Proponemos que la felicidad en el trabajo se compone de tres constructos ya consolidados en la literatura. La primera hipótesis de esta investigación es que …
First stages of microsporere programming to embryogenesis through anther culture in Prunus armeniaca L.
2011
6 páginas, 3 figuras, 2 tablas -- PAGS nros. 152-157
Arbitrarily shaped plates analysis via Line Element-Less Method (LEM)
2018
Abstract An innovative procedure is introduced for the analysis of arbitrarily shaped thin plates with various boundary conditions and under generic transverse loading conditions. Framed into Line Element-less Method, a truly meshfree method, this novel approach yields the solution in terms of the deflection function in a straightforward manner, without resorting to any discretization, neither in the domain nor on the boundary. Specifically, expressing the deflection function through a series expansion in terms of harmonic polynomials, it is shown that the proposed method requires only the evaluation of line integrals along the boundary parametric equation. Further, minimization of appropri…
Environmentally Assessing Buildings Characterized by Complex Shape and Innovative Materials
2013
This paper addresses the emerging problem consisting in a correct energy and environmental evaluation of buildings belonging to the new architectural tendency. In fact, innovative buildings are often characterized by new materials that, not rarely, are not contemplated in current environmental databases. Moreover, unconventional shapes of these buildings could require further manufacturing processes that involve additional energy consumption not included in the commercial environmental database. Through the work a spotlighting of the problem is presented with reference to a real innovative building.