Search results for "HAp"

The Role of Molecular Chaperones in Virus Infection and Implications for Understanding and Treating COVID-19

2020

The COVID-19 pandemic made imperative the search for means to end it, which requires a knowledge of the mechanisms underpinning the multiplication and spread of its cause, the coronavirus SARS-CoV-2. Many viruses use members of the hosts’ chaperoning system to infect the target cells, replicate, and spread, and here we present illustrative examples. Unfortunately, the role of chaperones in the SARS-CoV-2 cycle is still poorly understood. In this review, we examine the interactions of various coronaviruses during their infectious cycle with chaperones in search of information useful for future research on SARS-CoV-2. We also call attention to the possible role of molecular mimicry in the dev…

Quantitative analysis of mixtures of metal-carbonyl complexes by Fourier-transform infrared spectroscopy: application to the simultaneous double immu…

1996

Abstract The feasibility of a double immunoassay of haptens by the nonisotopic carbonyl metalloimmunoassay (CMIA) method is demonstrated. Three different pairings of antiepileptic medications from the groups carbamazepine, diphenylhydantoin, and phenobarbital (for each of which a mono-CMIA is already available) were assayed by double CMIA. The assay method employs as tracers metal–carbonyl complexes that give very strong signals in the range of 1850–2200 cm −1 in the infrared spectrum, permitting quantitative analysis by Fourier-transform infrared spectroscopy. The fact that the signals are individually assignable and of comparable intensity permits quantitative analysis of mixtures of two …

Nrg1 haploinsufficiency alters inhibitory cortical circuits

2021

Neuregulin 1 (NRG1) and its receptor ERBB4 are schizophrenia (SZ) risk genes that control the development of both excitatory and inhibitory cortical circuits. Most studies focused on the characterization ErbB4 deficient mice. However, ErbB4 deletion concurrently perturbs the signaling of Nrg1 and Neuregulin 3 (Nrg3), another ligand expressed in the cortex. In addition, NRG1 polymorphisms linked to SZ locate mainly in non-coding regions and they may partially reduce Nrg1 expression. Here, to study the relevance of Nrg1 partial loss-of-function in cortical circuits we characterized a recently developed haploinsufficient mouse model of Nrg1 (Nrg1tm1Lex). These mice display SZ-like behavioral d…

Signorini problem with Coulomb's law of friction. Shape optimization in contact problems

1992

Mesonic enhancement of the weak axial charge and its effect on the half-lives and spectral shapes of first-forbidden J+↔J− decays

2018

The effects of the enhancement of the axial-charge matrix element γ5 were studied in medium heavy and heavy nuclei for first-forbidden J+↔J− decay transitions using the nuclear shell model. Noticeable dependence on the enhancement ϵMEC of the axial-charge matrix element, as well as on the value of the axial-vector coupling constant gA was found in the spectral shapes of $^{93}$Y, $^{95}$Sr, and $^{97}$Y. The importance of the spectrum of $^{138}$Cs in the determination of gA is discussed. Half-life analyses in the A≈95 and A≈135 regions were done, and consistent results gA≈0.90, 0.75, and 0.65, corresponding to the three enhancement scenarios ϵMEC=1.4, 1.7, and 2.0, were obtained. Connectio…

A line-shape analysis for spin-1 NMR signals

1997

An analytic model of the deuteron absorption function has been developed and is compared to experimental NMR signals of deuterated butanol obtained at the SMC experiment in order to determine the deuteron polarization. The absorption function model includes dipolar broadening and a frequency-dependent treatment of the intensity factors. The high-precision TE signal data available are used to adjust the model for Q-meter distortions and dispersion effects. Once the Q-meter adjustment is made, the enhanced polarizations determined by the asymmetry and TE-calibration methods compare well within the accuracy of each method. In analyzing the NMR signals, the quadrupolar coupling constants could …

Nonlinear pulse deceleration using photorefractive four-wave mixing

2009

We investigate the possibilities of the backward four-wave coupling based on the nonlocal photorefractive response for the nonlinear deceleration of light pulses. The presence of an additional external variable parameter—the pump intensity ratio—allows to improve the output characteristics of the decelerated pulses compared to those typical of the two-wave coupling. In particular, large delay times of the output pulses can be achieved without their strong amplification. This positive distinctive feature of the pulse deceleration occurs far from threshold of the mirrorless optical oscillation.

Le monastère Saint-Pierre d'Osor (île de Cres) : septième campagne d'études archéologiques

2013

The 2012 campaign of the archaeological research project permitted the exhaustive excavations of the immediate surroundings of the southern nave of the abbey church of St Peter in Osor. The richness and the complexity of the discovered structures confirmed the great archaeological potential of this sector. Namely, a funeral zone that is situated south to the church is occupied by two buildings perpendicular to the church which we interpret as a mausoleum (the one on the west) and a chapel with one privileged burial (the one on the east). The great number of built tombs or simples graves confirmed that this sector had funeral function even before the XIth century and the construction of the …

Gametic embryogenesis and haploid technology as valuable support to plant breeding

2011

Plant breeding is focused on continuously increasing crop production to meet the needs of an ever-growing world population, improving food quality to ensure a long and healthy life and address the problems of global warming and environment pollution, together with the challenges of developing novel sources of biofuels. The breeders' search for novel genetic combinations, with which to select plants with improved traits to satisfy both farmers and consumers, is endless. About half of the dramatic increase in crop yield obtained in the second half of the last century has been achieved thanks to the results of genetic improvement, while the residual advance has been due to the enhanced managem…

Protective Effects of L- and D-Carnosine on R-Crystallin Amyloid Fibril Formation: Implications for Cataract Disease

2009

Mildly denaturing conditions induce bovine ?-crystallin, the major structural lens protein, to self-assemble into fibrillar structures in vitro. The natural dipeptide L-carnosine has been shown to have potential protective and therapeutic significance in many diseases. Carnosine derivatives have been proposed as potent agents for ophthalmic therapies of senile cataracts and diabetic ocular complications. Here we report the inhibitory effect induced by the peptide (L- and D-enantiomeric form) on ?-crystallin fibrillation and the almost complete restoration of the chaperone activity lost after denaturant and/or heat stress. Scanning force microscopy (SFM), thioflavin T, and a turbidimetry ass…