Search results for "HB"
showing 10 items of 1066 documents
Large multiple neighborhood search for the soft-clustered vehicle-routing problem
2021
Abstract The soft-clustered vehicle-routing problem (SoftCluVRP) is a variant of the classical capacitated vehicle-routing problem. Customers are partitioned into clusters and all customers of the same cluster must be served by the same vehicle. In this paper, we present a large multiple neighborhood search for the SoftCluVRP. We design and analyze multiple cluster destroy and repair operators as well as two post-optimization components, which are both based on variable neighborhood descent. The first allows inter-route exchanges of complete clusters, while the second searches for intra-route improvements by combining classical neighborhoods (2-opt, Or-opt, double-bridge) and the Balas-Simo…
Opportunities for the Use of Business Data Analysis Technologies
2016
Abstract The paper analyses the business data analysis technologies, provides their classification and considers relevant terminology. The feasibility of business data analysis technologies handling big data sources is overviewed. The paper shows the results of examination of the online big data source analytics technologies, data mining and predictive modelling technologies and their trends.
K-nearest neighbor driving active contours to delineate biological tumor volumes
2019
Abstract An algorithm for tumor delineation in positron emission tomography (PET) is presented. Segmentation is achieved by a local active contour algorithm, integrated and optimized with the k-nearest neighbor (KNN) classification method, which takes advantage of the stratified k-fold cross-validation strategy. The proposed approach is evaluated considering the delineation of cancers located in different body districts (i.e. brain, head and neck, and lung), and considering different PET radioactive tracers. Data are pre-processed in order to be expressed in terms of standardized uptake value, the most widely used PET quantification index. The algorithm uses an initial, operator selected re…
Iterated greedy with variable neighborhood search for a multiobjective waste collection problem
2020
Abstract In the last few years, the application of decision making to logistic problems has become crucial for public and private organizations. Efficient decisions clearly contribute to improve operational aspects such as cost reduction or service improvement. The particular case of waste collection service considered in this paper involves a set of economic, labor and environmental issues that translate into difficult operational problems. They pose a challenge to nowadays optimization technologies since they have multiple constraints and multiple objectives that may be in conflict. We therefore need to resort to multiobjective approaches to model and solve this problem, providing efficie…
Improving the performance of embedded systems with variable neighborhood search
2017
Graphical abstractDisplay Omitted Embedded systems have become an essential part of our lives, mainly due to the evolution of technology in the last years. However, the power consumption of these devices is one of their most important drawbacks. It has been proven that an efficient use of the memory of the device also improves its energy performance. This work efficiently solves the dynamic memory allocation problem, which can be formally defined as follows: given a program that has to be executed by a circuit, the objective is to fit that program in memory in such a way that the computing time required to execute it is minimized. In this work, we propose a parallel variable neighborhood se…
Antibodies against Lewis antigens inhibit the binding of human norovirus GII.4 virus-like particles to saliva but not to intestinal Caco-2 cells.
2016
BACKGROUND: Human noroviruses (NoVs) are the main cause of gastroenteritis worldwide. The most commonly detected NoV strains belong to the genetically diverse GII.4 genotype, with new pandemic variants emerging periodically. Despite extensive efforts, NoV investigation has been hampered by the lack of an effective in vitro cell culture system. However, NoV-derived recombinant virus-like particles (VLPs) resembling empty capsids are good surrogates for analysing NoV antigenicity and virus-ligand interactions. NoV VLPs have been reported to bind to histo-blood group antigens (HBGAs). We have analysed the ability of NoV VLPs derived from GI.1 genotype and from three GII.4 genotype variants, GI…
KIR2DL3 and the KIR ligand groups HLA-A-Bw4 and HLA-C2 predict the outcome of hepatitis B virus infection.
2017
Killer immunoglobulin-like receptors (KIRs) regulate the activation of Natural Killer cells through their interaction with human leukocyte antigens (HLA). KIR and HLA loci are highly polymorphic and certain HLA-KIR combinations have been found to protect against viral infections. In this study we analyzed whether the KIR/HLA repertoire may influence the course of hepatitis B virus (HBV) infection. Fifty-seven subjects with chronic hepatitis B (CHB), 44 subjects with resolved HBV infection, and 60 healthy uninfected controls (HC) were genotyped for KIR and their HLA ligands. The frequency of the HLA-A-Bw4 ligand group was higher in CHB (58%) than subjects with resolved infection (23%) (crude…
Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions.
2020
Type 2 diabetes (T2D) is a very prevalent, multisystemic, chronic metabolic disorder closely related to atherosclerosis and cardiovascular diseases. It is characterised by mitochondrial dysfunction and the presence of oxidative stress. Metformin is one of the safest and most effective anti-hyperglycaemic agents currently employed as first-line oral therapy for T2D. It has demonstrated additional beneficial effects, unrelated to its hypoglycaemic action, on weight loss and several diseases, such as cancer, cardiovascular disorders and metabolic diseases, including thyroid diseases. Despite the vast clinical experience gained over several decades of use, the mechanism of action of metformin i…
Draft genome sequence of Thalassobius mediterraneus CECT 5383T, a poly-beta-hydroxybutyrate producer
2016
Thalassobius mediterraneus is the type species of the genus Thalassobius and a member of the Roseobacter clade, an abundant representative of marine bacteria. T. mediterraneus XSM19T (=CECT 5383T) was isolated from the Western Mediterranean coast near Valencia (Spain) in 1989. We present here the draft genome sequence and annotation of this strain (ENA/DDBJ/NCBI accession number CYSF00000000), which is comprised of 3,431,658 bp distributed in 19 contigs and encodes 10 rRNA genes, 51 tRNA genes and 3276 protein coding genes. Relevant findings are commented, including the complete set of genes required for poly-beta-hydroxybutyrate (PHB) synthesis and genes related to degradation of aromatic …
Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study
2018
PubMed: 29599078