Search results for "HB"
showing 10 items of 1066 documents
Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes
2021
AbstractRhodesain is the lysosomal cathepsin L-like cysteine protease ofT. brucei rhodesiense, the causative agent of Human African Trypanosomiasis. The enzyme is essential for the proliferation and pathogenicity of the parasite as well as its ability to overcome the blood-brain barrier of the host. Lysosomal cathepsins are expressed as zymogens with an inactivating pro-domain that is cleaved under acidic conditions. A structure of the uncleaved maturation intermediate from a trypanosomal cathepsin L-like protease is currently not available. We thus established the heterologous expression ofT. brucei rhodesiensepro-rhodesain inE. coliand determined its crystal structure. The trypanosomal pr…
A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses.
2002
Virus like particles (VLPs) are known to induce potent B cell responses in the absence of adjuvants. Moreover, epitope-specific antibody responses may be induced by VLPs that contain peptides inserted in their immunodominant regions. However, due to steric problems, the size of the peptides capable of being incorporated into VLPs while still permitting capsid assembly, is rather limited. While peptides genetically fused to either the N- or C-terminus of VLPs present fewer assembly problems, the immune responses obtained against such epitopes are often limited, most likely because the epitopes are not optimally exposed. In addition, such particles may be less stable in vivo. Here, we show th…
Effects of elevated hydrogen peroxide 'strip' bleaching on surface and subsurface enamel including subsurface histomorphology, micro-chemical composi…
2007
Abstract Objectives This study examined the effects of elevated concentration hydrogen peroxide tooth whitening treatments on tooth surface and subsurface integrity. Methods Sound human molars were ground and polished to prepare an uniform substrate for bleaching treatments. A cycling treatment included alternating ex vivo human salivary exposures with bleaching treatments under conditions of controlled temperature and durations of treatment. Bleaching was carried out with prototype bleaching strips containing hydrogen peroxide gel at 13% and 16% concentrations. A non-bleached group was used as a control. Treatments included 28 h of total bleaching exposure in vitro . Surface color was meas…
Mettre à jour les réseaux politiques ou définir le populisme ? L'attitude des médias face à la droite populiste allemande
2018
International audience; En Allemagne, l’espace politique entre la droite parlementaire et l’extrême droite est peu structuré. Les limites entre chaque camp manquent de clarté et laissent la place au développement d’une zone intermédiaire où s’exprime un populisme rassemblant des personnalités venues de divers horizons (membres de partis politiques, d’associations, intellectuels). En effet, ces personnes font office de passeurs entre les deux pôles, et elles s’illustrent dans les médias en prenant position dans des débats politiques particuliers qu’elles animent par leur engagement volontiers polémique (souveraineté nationale, rejet de l’Europe, lutte contre l’immigration…).Cet article analy…
Role of Social Partners for Work-Based Learning: Results of Surveys
2016
Abstract Introduction of work-based learning (WBL) in Latvia has required new approaches in decision making of different stakeholders. Experience from countries with long-standing WBL tradition has shown the numerous advantages but also the challenges this approach presents. One of these challenges is the need for new forms and mechanisms of cooperation among the key stakeholders – policy makers, public administrators, employers, educators and social partners. The current paper analyses the results of scientific research in this field, as well as uses the empirical results of two surveys performed by the authors: a survey of public sector experts and a survey of employers in Latvia. In orde…
Livländisches Koch- und Wirthschaftsbuch für große und kleinere Haushaltungen: ein Handbuch zum Selbstunterricht... [Koch und Wirthschaftsbuch für...…
1817
Autore izdevumā nav uzrādīta
Desarrollo y caracterización de nuevos nanobiocomposites con propiedades mejoradas mediante varios métodos de procesado de interés en envasado de ali…
2015
El presente trabajo tiene como objetivo mejorar las propiedades de matrices biopoliméricas para su uso en aplicaciones de envasado de alimentos mediante el desarrollo de nanobiocompuestos utilizando diferentes metodologías de procesado o estrategias de incorporación de materiales nanoestructurados en el interior de las matrices biopoliméricas. Dos estrategias de incorporación fueron empleadas. La primera de ellas estaba basada en una pre-incorporación de los aditivos nanoestructurados, también llamados nanoaditivos, en oligómeros de ácido láctico mediante tecnologías de polimerización in situ (específicamente policondensación), dando lugar a masterbatches que, posteriormente, se mezclaban c…
Capillary Rise in Nanopores: Molecular Dynamics Evidence for the Lucas-Washburn Equation
2007
When a capillary is inserted into a liquid, the liquid will rapidly flow into it. This phenomenon, well studied and understood on the macroscale, is investigated by Molecular Dynamics simulations for coarse-grained models of nanotubes. Both a simple Lennard-Jones fluid and a model for a polymer melt are considered. In both cases after a transient period (of a few nanoseconds) the meniscus rises according to a $\sqrt{\textrm{time}}$-law. For the polymer melt, however, we find that the capillary flow exhibits a slip length $\delta$, comparable in size with the nanotube radius $R$. We show that a consistent description of the imbibition process in nanotubes is only possible upon modification o…
Ruolo dell'interazione NK/KIR nella storia naturale delle infezioni virali
2017
Immunological mechanisms involved in the genesis of the immune response against viral infections take into account the activation of both innate adaptative response. Innate immune defenses trigger a rapid local response, which is often sufficient to control viral infection, and promotes the subsequent activation of specific immune defenses. Natural killer (NK) cells that constitute a subpopulation of lymphocyte-related cells are a key factor of innate immune response and play a role in defense against viral infections by killing infected cells or by producing cytokines and interacting with adaptative immune system's cells. Killer immunoglobulin-like receptors (KIRs) regulate the activation …
A Smoothed Particle Image Reconstruction method
2010
Many image processing techniques work with scattered data distribution usually employing grid based methods leading to numerical problems. To address this issue, a numerical method avoiding mesh generation can be used. Such a method performs an integral representation by means of a smoothing kernel function and, in the discrete formulation, involves domain particles. In this paper the meshless Smoothed Particle Hydrodynamics method is proposed in the Image Reconstruction context and a new computational strategy called Smoothed Particle Image Reconstruction is presented; the new method is based on a scatter approach and several innovative ideas are introduced in order to improve the computat…